Results 81 to 90 of about 75,561 (275)

Transintestinal and Biliary Cholesterol Secretion Both Contribute to Macrophage Reverse Cholesterol Transport in RatsBrief Report

, 2017
Objective-Reverse cholesterol transport comprises efflux of cholesterol from macrophages and its subsequent removal from the body with the feces and thereby protects against formation of atherosclerotic plaques.
Dikkers, Arne, Havinga, Rick, Albert K. Groen, Rick Havinga, Folkert Kuipers, Schonewille, Marleen, Marleen Schonewille, Koehorst, Martijn, Martijn Koehorst, Uwe J.F. Tietge, Kuipers, Folkert, Tietge, Uwe J F, Boer, de, Jan Freark, Koehorst, Martijn; id_orcid, Kuipers, Folkert; id_orcid, Arne Dikkers, Jan Freark de Boer, Groen, Albert K   +17 more
core   +1 more source

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice [PDF]

, 2013
Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma.
Swartz, Melody, Fulp, B., Swartz, M.A., Wenjun Li, Tall, Alan R., Thomas, M.J., Swartz, Melody A, Marit Westerterp, Mary G. Sorci-Thomas, Gautier, Emmanuel, Martel, C., Thomas, Michael J, Gautier, E.L., Tall, Alan, Melody A. Swartz, Shu-Hsia Chen, Kreisel, D., Platt, Andrew M., Swartz, Melody A., Bittman, R., Catherine Martel, Platt, A.M., Gwendalyn J. Randolph, Westerterp, M., Brian Fulp, Sorci-Thomas, Mary G., Westerterp, Marit, Daniel Kreisel, Li, W., Thomas, Michael, Li, Wenjun, Robert Bittman, Sorci-Thomas, Mary G, Michael J. Thomas, Alan R. Tall, Martel, Catherine, Sorci-Thomas, Mary, Sorci-Thomas, M.G., Bittman, Robert, Randolph, Gwendalyn, Randolph, Gwendalyn J, Fulp, Brian, Andrew M. Platt, Randolph, Gwendalyn J., Gautier, Emmanuel L., Chen, Shu-Hsia, Thomas, Michael J., Chen, S., Randolph, G.J., Emmanuel L. Gautier, Tall, A.R., Tall, Alan R, Platt, Andrew M, Kreisel, Daniel, Platt, Andrew   +54 more
core   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Zymosan-mediated inflammation impairs in vivo reverse cholesterol transport[S]

Journal of Lipid Research, 2011
Inflammation has been proposed to impair HDL function and reverse cholesterol transport (RCT). We investigated the effects of inflammation mediated by zymosan, a yeast glucan, on multiple steps along the RCT pathway in vivo and ex vivo.
Priya Malik, Stela Z. Berisha, Jennifer Santore, Colin Agatisa-Boyle, Gregory Brubaker, Jonathan D. Smith   +5 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

ProAlgaZyme and its subfractions increase plasma HDL cholesterol via upregulation of ApoA1, ABCA1, and SRB1, and inhibition of CETP in hypercholesterolemic hamsters

Nutrition and Dietary Supplements, 2012
Andreea Geamanu, Nadia Saadat, Arvind Goja, Monika Wadehra, Xiangming Ji, Smiti V GuptaNutrition and Food Science, Wayne State University, Detroit, MI, USABackground: Plasma HDL cholesterol levels are inversely related to cardiovascular disease, which is
Geamanu A, Saadat N, Goja A, Wadehra M, Ji X, Gupta SV   +5 more
doaj  

International Symposium on Reverse Cholesterol Transport. Report on a meeting.

Journal of Lipid Research, 1990
The purpose of this symposium was to provide a forum for the reporting of recent findings and the exchange of ideas concerning reverse cholesterol transport, an area of intense interest and some controversy.
AG Lacko, PH Pritchard
doaj   +1 more source