Results 41 to 50 of about 124,891 (298)

Cholesterol Efflux and Reverse Cholesterol Transport [PDF]

, 2014
Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the formation of the atherosclerotic plaque, characterized by the accumulation of abnormal amounts of cholesterol and macrophages in the artery wall. Reverse cholesterol transport (RCT) may counteract the pathogenic events leading to the formation and development of ...
FAVARI, Elda, Chroni, Angelika, Tietge, Uwe J. F, ZANOTTI, Ilaria, Escolà Gil, Joan Carles, BERNINI, Franco   +5 more
openaire   +4 more sources

Molecular physiology of reverse cholesterol transport.

Journal of Lipid Research, 1995
Reverse cholesterol transport (RCT) is the pathway by which peripheral cell cholesterol can be returned to the liver for catabolism. Evidence of specific functions for molecular structures within individual plasma lipoprotein species has rapidly ...
C J Fielding, P E Fielding
doaj   +1 more source

Reverse cholesterol transport and cholesterol efflux in atherosclerosis [PDF]

QJM: An International Journal of Medicine, 2005
Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis. Major constituents of RCT include acceptors such as high-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), and enzymes such as lecithin:cholesterol acyltransferase ...
R, Ohashi, H, Mu, X, Wang, Q, Yao, C, Chen   +4 more
openaire   +2 more sources

Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of preβ-high density lipoprotein to α-high density lipoprotein

Journal of Lipid Research, 2000
The properties of the mature and pro-forms of recombinant apolipoprotein A-I (apoA-I) were compared with those of apoA-I isolated from human plasma.
Dmitri Sviridov, Louise E. Pyle, Matti Jauhiainen, Christian Ehnholm, Noel H. Fidge   +4 more
doaj   +1 more source

Rethinking reverse cholesterol transport and dysfunctional high-density lipoproteins. [PDF]

J Clin Lipidol, 2018
Gillard BK, Rosales C, Xu B, Gotto AM, Pownall HJ.   +4 more
europepmc   +2 more sources

Reverse cholesterol transport revisited. [PDF]

World journal of gastroenterology, 2011
Reverse cholesterol transport was originally described as the high-density lipoprotein-mediated cholesterol flux from the periphery via the hepatobiliary tract to the intestinal lumen, leading to fecal excretion. Since the introduction of reverse cholesterol transport in the 1970s, this pathway has been intensively investigated. In this topic highlight,
Gemma, Brufau, Albert K, Groen, Folkert, Kuipers   +2 more
openaire   +4 more sources

Extracellular cholesterol-rich microdomains generated by human macrophages and their potential function in reverse cholesterol transport

Journal of Lipid Research, 2010
Previous studies have shown that cholesterol in atherosclerotic plaques is present in both intracellular and extracellular forms. In the current study, we investigated a mechanism for extracellular cholesterol accumulation and examined the capacity of ...
Daniel S. Ong, Joshua J. Anzinger, Francisco J. Leyva, Noa Rubin, Lia Addadi, Howard S. Kruth   +5 more
doaj   +1 more source

Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations

Journal of Lipid Research, 2003
The current model for reverse cholesterol transport proposes that HDL transports excess cholesterol derived primarily from peripheral cells to the liver for removal.
Federica Basso, Lita Freeman, Catherine L. Knapper, Alan Remaley, John Stonik, Edward B. Neufeld, Terese Tansey, Marcelo J.A. Amar, Jamila Fruchart-Najib, Nicholas Duverger, Silvia Santamarina-Fojo, H.Bryan Brewer, Jr.   +11 more
doaj   +1 more source

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux

Journal of Lipid Research, 2009
Peroxisome proliferator-activated receptor delta (PPARδ) is involved in regulation of energy homeostasis. Activation of PPARδ markedly increases fecal neutral sterol secretion, the last step in reverse cholesterol transport.
Carlos L.J. Vrins, Astrid E. van der Velde, Karin van den Oever, Johannes H.M. Levels, Stephane Huet, Ronald P.J. Oude Elferink, Folkert Kuipers, Albert K. Groen   +7 more
doaj   +1 more source

Importance of macrophage cholesterol content on the flux of cholesterol mass

Journal of Lipid Research, 2010
Net flux of cholesterol represents the difference between efflux and influx and can result in net cell-cholesterol accumulation, net cell-cholesterol depletion, or no change in cellular cholesterol content.
Sandhya Sankaranarayanan, Margarita de la Llera-Moya, Denise Drazul-Schrader, Bela F. Asztalos, Ginny L. Weibel, George H. Rothblat   +5 more
doaj   +1 more source