Results 61 to 70 of about 124,891 (298)
High density lipoprotein – a hero, a mirage or a witness?
Frontiers in Cardiovascular Medicine, 2014 Negative relationship between plasma High Density Lipoprotein (HDL) levels and risk of cardiovascular disease is a firmly established medical fact, but attempts to reproduce protective properties of HDL by pharmacologically elevating HDL levels were ...
Dmitri eSviridov
doaj +1 more source
2nd International Symposium on Reverse Cholesterol Transport: report on a meeting.
Journal of Lipid Research, 1994 The purpose of this symposium was to provide a forum for presenting recent findings and for exchange of ideas concerning reverse cholesterol transport.
A G Lacko, P H Pritchard
doaj +1 more source
Utilizing the LoxP-Stop-LoxP System to Control Transgenic ABC-Transporter Expression In Vitro
Biomolecules, 2022 ABCA1 and ABCG1 are two ABC-transporters well-recognized to promote the efflux of cholesterol to apoAI and HDL, respectively. As these two ABC-transporters are critical to cholesterol metabolism, several studies have assessed the impact of ABCA1 and ...
Ikechukwu Esobi +3 more
doaj +1 more source
Anatolian journal of cardiology, 2017 A key to effective treatment of cardiovascular disease is to understand the body’s complex lipoprotein transport system. Reverse cholesterol transport (RCT) is the process of cholesterol movement from the extrahepatic tissues back to the liver ...
K. Trajkovska, S. Topuzovska
semanticscholar +1 more source
Alcohol consumption stimulates early steps in reverse cholesterol transport
Journal of Lipid Research, 2001 Alcohol consumption is associated with increased HDL cholesterol levels, which may indicate stimulated reverse cholesterol transport. The mechanism is, however, not known.
M.S. van der Gaag +5 more
doaj +1 more source
JCI Insight, 2019 BACKGROUND HDL that contains apolipoprotein E (apoE) is a subspecies especially active in steps in reverse cholesterol transport, a process that brings cholesterol from peripheral cells to the liver. Here, we studied the effect of dietary unsaturated fat
Allyson M. Morton +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source