Results 71 to 80 of about 113,812 (280)
Coarse-Grained Model for Phospholipid/Cholesterol Bilayer [PDF]
, 2004 We construct a coarse-grained (CG) model for dipalmitoylphosphatidylcholine (DPPC)/cholesterol bilayers and apply it to large-scale simulation studies of lipid membranes. Our CG model is a two-dimensional representation of the membrane, where the individual lipid and sterol molecules are described by point-like particles.
arxiv +1 more source
World journal of gastroenterology, 2010 Reduction of low-density lipoprotein-cholesterol through statin therapy has only modestly decreased coronary heart disease (CHD)-associated mortality in developed countries, which has prompted the search for alternative therapeutic strategies for CHD.
J. Mark Brown, Ryan E. Temel
openaire +3 more sources
High‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles
Advanced Functional Materials, EarlyView.The layer‐by‐layer (LbL) assembly of polymer films on nanoparticle (NP) surfaces is a promising technique for targeted drug delivery. Despite its success in preclinical mouse models, a current good manufacturing practices (cGMP) compliant, clinical‐scale production method has been lacking.
Ivan S. Pires +4 more
wiley +1 more source
Importance of macrophage cholesterol content on the flux of cholesterol mass
Journal of Lipid Research, 2010 Net flux of cholesterol represents the difference between efflux and influx and can result in net cell-cholesterol accumulation, net cell-cholesterol depletion, or no change in cellular cholesterol content.
Sandhya Sankaranarayanan +5 more
doaj
Morphology and Interaction between Lipid Domains [PDF]
, 2009 Cellular membranes are a heterogeneous mix of lipids, proteins and small molecules. Special groupings of saturated lipids and cholesterol form a liquid-ordered phase, known as `lipid rafts,' serving as platforms for signaling, trafficking and material transport throughout the secretory pathway.
arxiv +1 more source
Reverse cholesterol transport revisited.
World journal of gastroenterology, 2010 Reverse cholesterol transport was originally described as the high-density lipoprotein-mediated cholesterol flux from the periphery via the hepatobiliary tract to the intestinal lumen, leading to fecal excretion. Since the introduction of reverse cholesterol transport in the 1970s, this pathway has been intensively investigated. In this topic highlight,
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
Simulation studies of stratum corneum lipid mixtures [PDF]
, 2009 We present atomistic molecular dynamics results for fully hydrated bilayers composed of ceramide NS-24:0, free fatty acid 24:0 and cholesterol, to address the effect of the different components in the stratum corneum (the outermost layer of skin) lipid matrix on its structural properties.
arxiv +1 more source
Advanced Healthcare Materials, EarlyView.Minimal residual disease (MRD) leads to cancer relapse and poor survival in ovarian cancer. The lack of representative 3D models limits therapy development. The microfluidics‐based high throughput 3D microtumor platform described here generates clinically‐relevant MRD models. The 3D microtumors recapitulate the molecular signatures of MRD from patients.
Xingyun Yang +14 more
wiley +1 more source
Annals of Hepatology, 2017 Atherosclerosis is characterized by lipid accumulation, inflammatory response, cell death and fibrosis in the arterial wall, and is a major pathological basis for ischemic coronary heart disease (CHD), which is the leading cause of morbidity and ...
Helen H. Wang +4 more
doaj