Results 121 to 130 of about 1,758,180 (373)

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms*

Journal of Biological Chemistry, 2014
Background: 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a highly potent nucleoside analog reverse transcriptase (RT) inhibitor with a 3′-OH. Results: EFdA inhibits RT as an immediate or delayed chain terminator depending on the DNA substrate sequence.
E. Michailidis, Andrew D. Huber, E. M. Ryan, Y. T. Ong, Maxwell D. Leslie, Kayla B. Matzek, Kamalendra Singh, B. Marchand, Ariel N. Hagedorn, K. Kirby, L. Rohan, E. Kodama, H. Mitsuya, M. Parniak, S. Sarafianos   +14 more
semanticscholar   +1 more source

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]

, 2017
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao, Deng, Wuguo, Fu, Xiaoyan, Gao, Fan, Huang, Wenlin, Kang, Lan, Li, Wenbin, Li, Yixin, Liu, Tianze, Qin, Ge, Shi, Dingbo, Shi, Fen, Song, Chen, Tang, Bing, Tang, Ranran, Wu, Xiaojun, Xiao, Binyi, Xiao, Xiangsheng, Zhang, Changlin   +18 more
core   +1 more source

Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering

Advanced Healthcare Materials, EarlyView.
This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer, Arundhati Joshi, Constantin von Kaisenberg, Dorothea Brüggemann, Cornelia Lee‐Thedieck   +4 more
wiley   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Telomerase reverse transcriptase in the regulation of gene expression

BMB Reports, 2014
Telomerase plays a pivotal role in the pathology of aging and cancer by maintaining genome integrity, controlling cell proliferation, and regulating tissue homeostasis. Telomerase is essentially composed of an RNA component, Telomerase RNA or TERC, which
Junzhi Zhou, Deqiang Ding, Miao Wang, Y. Cong   +3 more
semanticscholar   +1 more source

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

Advanced Healthcare Materials, EarlyView.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente, Isabel Corraliza‐Gorjón, Thomas S. van Zanten, María del Puerto Morales, Leonor Kremer, Domingo F. Barber   +5 more
wiley   +1 more source

Phylogeny and drug resistance of HIV PR gene among HIV patients receiving RT inhibitors in Iran

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To survey the level and patterns of reverse transcriptase-based drug resistance and subtype distribution among antiretroviral-treated HIV-infected patients receiving only reverse transcriptase inhibitors in Iran. Methods: A total of 25 samples
Kazem Baesi, Majedeh Moradbeigi, Mehrdad Ravanshad, Ashrafolnesa Baghban   +3 more
doaj   +1 more source

Phosphonoformate Inhibits Reverse Transcriptase

Journal of General Virology, 1979
The new antiviral substance phosphonoformate (PFA) has been tested in a cell-free system for its effect on reverse transcriptases from an avian retrovirus (avian myeloblastosis virus, AMV) and from mammalian retroviruses (Rauscher leukaemia virus, RMuLV; bovine leukaemia virus; baboon endogenous virus; simian sarcoma virus; visna virus).
B, Sundquist, B, Oberg
openaire   +2 more sources

Fibrillar Bundles as Fibrous Filler Materials for Attaining Cell Anisotropy in Bioprinting

Advanced Healthcare Materials, EarlyView.
Fibrillar bundles are introduced as a bioprintable additive that enables robust and scalable cellular alignment within 3D constructs through flow‐induced orientation during extrusion. These fibers support strong cell adhesion and polarization across various cell types and significantly enhance myotube alignment in Gelatine‐Methacryloyl (GelMA ...
Sven Heilig, Zan Lamberger, Lys Sprenger, Vivien Priebe, Camilla Mussoni, Denitsa Docheva, Kristina Andelovic, Jürgen Groll, Sahar Salehi, Gregor Lang, Matthias Ryma   +10 more
wiley   +1 more source