Results 181 to 190 of about 565,542 (282)

Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design. [PDF]

Acta Pharm Sin B
Zhou Z, Sun Y, Feng D, Wang Z, Zhao F, Gao S, Zhan P, Kang D, Liu X.   +8 more
europepmc   +1 more source

Tissue Damage in Rheumatoid Arthritis is Genetically linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, Accepted Article.
Objectives Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biological mechanism underlying this association. Methods Expression of surrounding genes was compared between rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E Mains, Betty A Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

Structural basis of antiphage defence by an ATPase-associated reverse transcriptase. [PDF]

Nat Commun
George JT, Burman N, Wilkinson RA, de Silva S, McKelvey-Pham Q, Buyukyoruk M, Dale A, Landman H, Graham AB, DeLuca SZ, Wiedenheft B.   +10 more
europepmc   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Reverse transcriptase activity in psoriatic lesions: effects of reverse transcriptase inhibitors on keratinocyte proliferation and differentiation

Retrovirology, 2009
Bonté Frédéric, Dumas Marc, Tesniere Anne, Molès Jean-Pierre, Guilhou J-J   +4 more
doaj   +1 more source

Optimisation of peptides targeting reverse transcriptase HIV-1 using QSAR, machine learning, and computational approaches. [PDF]

Front Pharmacol
Mahendra FR, Prakoso I, Marzelino A, Rizqy Fadhillah M, Syukriyansyah, Hasibuan MMA, Suparningtyas JF, Kristiadi M, Setiawan AG, Rahman FI, Sari AN, Raysendria NR, Kurniawan I, Arozal W, Kusmardi K.   +14 more
europepmc   +1 more source

Intracellular self‐assembled nanoneedles for efficient lysosomal escape and CRISPR/Cas9 mediated gene editing

BMEMat, EarlyView.
PlaMnB was formed by cytolysin A‐tumor homing peptides (THP)‐modified bacterial membranes encapsulating the clustered regularly interspaced short palindromic repeat/CRISPR‐associated protein (CRISPR/Cas9) plasmid and manganese dioxide. THP‐containing bacterial membrane enhances PlaMnB vascular permeability and tumor targeting, and after cellular ...
Chen Zhang, Nan Zhang, Ruiqi Yang, Qian Qiu, Jiaying Huang, Jingang Liu, Silu Li, Jonathan F. Lovell, He Ren, Yumiao Zhang   +9 more
wiley   +1 more source

Lyophilised Reverse Transcriptase and Polymerase for Point-of-Care Diagnostics of SARS-CoV-2. [PDF]

Microb Biotechnol
Mutter N, Posch B, Gillitschka Y, Kataeva N, Michalek B, Lager D, Staniszewski F, Schilder A, Osinkina L, Westenthanner M, Stehr J, Buersgens F, Peham JR.   +12 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Protein-primed homopolymer synthesis by an antiviral reverse transcriptase. [PDF]

Nature
Tang S, Žedaveinytė R, Burman N, Pandey S, Ramirez JL, Kulber LM, Wiegand T, Wilkinson RA, Ma Y, Zhang DJ, Lampe GD, Berisa M, Jovanovic M, Wiedenheft B, Sternberg SH.   +14 more
europepmc   +1 more source