Results 181 to 190 of about 382,156 (284)

On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires [PDF]

, 2017
Sukrit Silas, Kira S. Makarova, Sergey Shmakov, David Páez-Espino, Georg Mohr, Yi Liu, Michelle Davison, Simon Roux, Siddharth R. Krishnamurthy, Becky Xu Hua Fu, Loren L Hansen, David Wang, Matthew B. Sullivan, Andrew Millard, Martha R. J. Clokie, Devaki Bhaya, Alan M. Lambowitz, Nikos C. Kyrpides, Eugene V. Koonin, Andrew Fire   +19 more
openalex   +1 more source

MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing. [PDF]

PLoS Biol
Raheem IT, Girijavallabhan V, Fillgrove KL, Goh SL, Bahnck-Teets C, Huang Q, Li F, Wan BL, O'Donnell GT, Patteson JB, Cilento ME, Bennet A, Hayes RP, Tummala S, McHale C, Wiltsie J, Ellis J, Asante-Appiah E, Hazuda DJ, Hale J, Grobler JA, Xu M, Diamond TL, Lai MT.   +23 more
europepmc   +1 more source

Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models [PDF]

, 2009
S. K. Mastan, Eswar Kumar Kilari
openalex   +1 more source

Physiologically based pharmacokinetic model combined with a clinical lactation study to determine doravirine concentrations in human breastmilk

British Journal of Clinical Pharmacology, EarlyView.
Aims To determine breastmilk concentrations of doravirine via PBPK modelling in combination with a clinical lactation study. As women living with HIV are not able to cease antiretroviral therapy during lactation, it is necessary to establish drug transfer into breastmilk to determine exposure of the infant to antiretroviral drugs and potential risk of ...
Lena van der Wekken‐Pas, David Burger, Rick Greupink, Angela Colbers   +3 more
wiley   +1 more source

Characterization of LTR Retrotransposon Reverse Transcriptase in <i>Tamarix chinensis</i> L. and Activity Analysis Under Salt and Alkali Stresses. [PDF]

Genes (Basel)
Wang L, Li B, Wang Y, Wang S, Zhang M, Li M, Zheng T, Wang H.   +7 more
europepmc   +1 more source

Stable Complexes Formed by HIV-1 Reverse Transcriptase at Distinct Positions on the Primer-template Controlled by Binding Deoxynucleoside Triphosphates or Foscarnet

, 2007
Peter R. Meyer, Wiriya Rutvisuttinunt, S. Matsuura, Antero G. So, Walter A. Scott   +4 more
openalex   +1 more source

Structural Determinants of Slippage-mediated Mutations by Human Immunodeficiency Virus Type 1 Reverse Transcriptase [PDF]

, 2006
Monica E. Hamburgh, Kenneth Curr, Melissa Monaghan, Vasudev R Rao, Snehlata Tripathi, Bradley D. Preston, Stefan G. Sarafianos, Eddy Arnold, Thomas A. Darden, Vinayaka R. Prasad   +9 more
openalex   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition. [PDF]

EMBO J
Han J, Liu B, Tang J, Zhang S, Wang X, Li X, Zhang Q, Liu Z, Wang W, Liu Y, Zhou R, Yin H, Wei Y, Li Z, Zhang M, Deng Z, Zhang H.   +16 more
europepmc   +1 more source

Intracellular self‐assembled nanoneedles for efficient lysosomal escape and CRISPR/Cas9 mediated gene editing

BMEMat, EarlyView.
PlaMnB was formed by cytolysin A‐tumor homing peptides (THP)‐modified bacterial membranes encapsulating the clustered regularly interspaced short palindromic repeat/CRISPR‐associated protein (CRISPR/Cas9) plasmid and manganese dioxide. THP‐containing bacterial membrane enhances PlaMnB vascular permeability and tumor targeting, and after cellular ...
Chen Zhang, Nan Zhang, Ruiqi Yang, Qian Qiu, Jiaying Huang, Jingang Liu, Silu Li, Jonathan F. Lovell, He Ren, Yumiao Zhang   +9 more
wiley   +1 more source