Results 191 to 200 of about 382,156 (284)

In vitro comparison of the susceptibilities of the same drug resistance mutations to reverse-transcriptase inhibitors of subtype B and CRF01_AE HIV-1 strains. [PDF]

Sci Rep
Li H, Shen K, Han J, Liu Y, Zhang L, Liu X, Jia L, Zhang B, Wang X, Li J, Dai E, Yan H, Li L.   +12 more
europepmc   +1 more source

Recent Advances in Chemical Probing Strategies for RNA Structure Determination in Vivo

Chemistry – A European Journal, EarlyView.
This Review illustrates how structural probes combined with advanced sequencing technologies are revolutionizing our ability to map RNA structures and interactions within living cells. It highlights the development of innovative strategies tailored to probe RNA structures in particular biological contexts.
Maryana Yarshova, Jieyu Zhao, Chun Kit Kwok   +2 more
wiley   +1 more source

Preoperative Detection of Dual TERT Promoter Mutations in Thyroid Cancer: A Case Series

Diagnostic Cytopathology, EarlyView.
ABSTRACT Telomerase reverse transcriptase promoter (TERTp) mutations are associated with aggressive thyroid cancer and are most frequently found in anaplastic and poorly differentiated thyroid cancer. Pre‐operative thyroid nodule molecular testing can detect TERTp, denoting a high risk of malignancy and possible aggressive clinical features such as ...
Amir Harari, Jennifer Huiras, Yang Chen, Mohammed Alshalalfa, Yangyang Hao, Joshua P. Klopper, Richard T. Kloos, Bianca J. Vazquez   +7 more
wiley   +1 more source

HIV reverse transcriptase [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources

Patterns of Reverse Transcriptase Inhibitor Resistance Mutations in People Living with Human Immunodeficiency Virus in Libreville, Gabon. [PDF]

Trop Med Infect Dis
Nzengui-Nzengui GF, Mourembou G, Ibinga E, Kombila-Koumavor AC, M'boyis-Kamdem H, Mpouho-Ntsougha EM, Mombo-Mombo A, Ndjoyi-Mbiguino A.   +7 more
europepmc   +1 more source

Kinetic Insightsinto the Enhanced Antiviral Activityof Islatravir against Doravirine Resistance-Associated SubstitutionMutations in HIV‑1 Reverse Transcriptase

Nikita Zalenski (22154712), Derek J. Savoie (22154715), Amit Gaur (12240707), Neil A. Patel (22154718), David J. Suo (22154721), Turner W. Seay (22154724), Daniel Betancourt (22154727), Zucai Suo (258513)   +7 more
openalex   +1 more source

Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

, 2015
Zheng-Yong Wan, Jin Yao, Yuan Tao, Tian-Qi Mao, Xin-Long Wang, Yi-Pei Lu, Haifeng Wang, Hong Yin, Yan Wu, Fen‐Er Chen, Erik De Clercq, Dirk Daelemans, Christophe Pannecouque   +12 more
openalex   +2 more sources

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Developmental Dynamics, EarlyView.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez, Niusha Banoukh, Fiona Mensching, Robert V. Skibbens, M. Kathryn Iovine   +4 more
wiley   +1 more source

Reverse transcriptase inhibitors in Aicardi-Goutières syndrome: A crossover clinical trial. [PDF]

Dev Med Child Neurol
Crow YJ, Briggs TA, Eleftheriou D, Parida A, Battison C, Giddings A, Kennel T, Parker RA, AGS‐RTIs Study Group.   +8 more
europepmc   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source