Results 201 to 210 of about 565,542 (282)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells. [PDF]

MedComm (2020)
Park JH, Lee JC, Sharma S, Jiang C, Lee H, Park HJ, Kim HS.   +6 more
europepmc   +1 more source

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source

Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. [PDF]

Bioorg Med Chem Lett
Frost GB, Liu Y, Kron SJ, Scheidt KA.
europepmc   +1 more source

Lactate receptor HCAR1 in neonatal hypoxic–ischemic seizures

Epilepsia, EarlyView.
Abstract Hydroxycarboxylic acid receptor 1 (HCAR1) is a G‐protein‐coupled lactate receptor expressed in the brain and plays a role in neuronal excitability and repair after injury. Hypoxic–ischemic encephalopathy (HIE) is the most common cause of brain injury and seizures in term neonates.
Jennifer Burnsed, Angelina June, Maria Marlicz, Emmy Zucker, Ellie Kain‐Kuzniewski, Hannah Mulhern, Leanne Maharaj, John Williamson, Chengsan Sun, Suchitra Joshi, Huayu Sun, Jaideep Kapur   +11 more
wiley   +1 more source

MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing. [PDF]

PLoS Biol
Raheem IT, Girijavallabhan V, Fillgrove KL, Goh SL, Bahnck-Teets C, Huang Q, Li F, Wan BL, O'Donnell GT, Patteson JB, Cilento ME, Bennet A, Hayes RP, Tummala S, McHale C, Wiltsie J, Ellis J, Asante-Appiah E, Hazuda DJ, Hale J, Grobler JA, Xu M, Diamond TL, Lai MT.   +23 more
europepmc   +1 more source

Relationship between hTERT levels and oxidative stress in epilepsy patients

Epilepsia Open, EarlyView.
Abstract Objective Human telomerase reverse transcriptase (hTERT) is a key determinant of telomere maintenance and cellular aging. Oxidative stress plays a role in neurodegenerative processes by causing cellular damage through increased reactive oxygen species.
Muhammed Mehdi Üremiş, Deniz Tuncel Berktaş, Nuray Üremiş, Fatma İnanç Tolun   +3 more
wiley   +1 more source

Characterization of LTR Retrotransposon Reverse Transcriptase in <i>Tamarix chinensis</i> L. and Activity Analysis Under Salt and Alkali Stresses. [PDF]

Genes (Basel)
Wang L, Li B, Wang Y, Wang S, Zhang M, Li M, Zheng T, Wang H.   +7 more
europepmc   +1 more source

Rumen Mycobiome Thiamine Metabolism Contributes to Subacute Rumen Acidosis Tolerance in Goats Through Enhancing Epithelial Cell Proliferation via IGFBP2/IGF1 Axis Activation

Exploration, EarlyView.
Schematic illustration of the mechanism underlying the differences between SARA‐susceptible and SARA‐tolerant dairy goats fed a high‐concentrate diet. SARA‐susceptible goats (HCS) exhibit low rumen pH and metabolic decline, characterized by epithelial inflammation.
Jingyi Xu, Xiaodong Chen, Yi Ma, Jianrong Ren, Guanghao Xu, Peilin Zhang, Wenhao Jia, Quanqiu Deng, Yuquan Xiao, Junhu Yao, Shengru Wu   +10 more
wiley   +1 more source

Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition. [PDF]

EMBO J
Han J, Liu B, Tang J, Zhang S, Wang X, Li X, Zhang Q, Liu Z, Wang W, Liu Y, Zhou R, Yin H, Wei Y, Li Z, Zhang M, Deng Z, Zhang H.   +16 more
europepmc   +1 more source