Results 201 to 210 of about 1,758,180 (373)

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, EarlyView.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

The Expression of hTERT mRNA and p16 Protein in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2009
Background and objective hTERT and p16 are involved in oncogenesis and development of tumor. The aim of this study is to investigate the expression of human telomerase reverse transcriptase (hTERT) and p16 in non-small cell lung cancer (NSCLC).
Lei XIAN, Huafu ZHOU, Xinghua ZHANG, Bangde XUE, Jianji GUO, Xu FENG   +5 more
doaj  

Centrosome amplification induced by the antiretroviral nucleoside reverse transcriptase inhibitors lamivudine, stavudine, and didanosine

, 2009
Mia Yu, Yvona Ward, Miriam C. Poirier, Ofelia A. Olivero   +3 more
openalex   +1 more source

1179. Cancer-Specific Killing by the Suicide Gene (CD) Using the Human Telomerase Reverse Transcriptase Promoter [PDF]

, 2002

openalex   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Efficient circRNA Detection Using the Processive Reverse Transcriptase uMRT. [PDF]

Bio Protoc
Warkentin R, Pyle AM.
europepmc   +1 more source

Synthetic evolutionary origin of a proofreading reverse transcriptase

Science, 2016
Jared W. Ellefson, J. Gollihar, Raghav Shroff, H. Shivram, V. Iyer, A. Ellington   +5 more
semanticscholar   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, EarlyView.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Porcine somatic cell nuclear transfer using telomerase reverse transcriptase-transfected mesenchymal stem cells reduces apoptosis induced by replicative senescence

, 2020
Ryoung‐Hoon Jeon, Gyu‐Jin Rho
openalex   +2 more sources