Results 241 to 250 of about 565,542 (282)

Amentoflavone, a Preferentially TGF‐β Receptor 1 Inhibitor, Alleviates Cardiac Remodeling and Dysfunction Through Modulating the TGF‐β/Smad and MAPK Signaling Pathways

Phytotherapy Research, EarlyView.
Amentoflavone, a preferentially TGF‐ββ receptor 1 inhibitor, attenuates transverse aortic constriction (TAC)‐triggered cardiac hypertrophy, fibrosis, and dysfunction by suppressing downstream Smad and MAPK signaling cascades in cardiomyocytes and cardiac fibroblasts.
Jiangjiao Wu, Chengcheng Zhao, Xiaoping Li, Xinyi Guo, Wenjie Tan, Lu Zhou, Ye Zhang, Jianli Zhang, Shuo Zheng, Chunyu Zeng, Gengze Wu   +10 more
wiley   +1 more source

Promoted read-through and mutation against pseudouridine-CMC by an evolved reverse transcriptase. [PDF]

Commun Biol
He Z, Qiu W, Zhou H.
europepmc   +1 more source

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Tenofovir and Doravirine Are Potential Reverse-Transcriptase Analogs in Combination with the New Reverse-Transcriptase Translocation Inhibitor (Islatravir) Among Treatment-Experienced Patients in Cameroon: Designing Future Treatment Strategies for Low- and Middle-Income Countries. [PDF]

Viruses
Nka AD, Bouba Y, Tsapi Lontsi WR, Gouissi Anguechia DH, Teto G, Ka'e AC, Semengue ENJ, Ambe Chenwi C, Takou D, Forgwei L, Tekoh TA, Ngueko AMK, Fokou BB, Efakika Gabisa J, Tchouaket MCT, TognaPabo WL, Ayuk Ngwese DT, Njiki Bikoi J, Armenia D, Colizzi V, Yotebieng M, Ndembi N, Santoro MM, Ceccherini-Silberstein F, Perno CF, Ndjolo A, Fokam J.   +26 more
europepmc   +1 more source

Evaluation of Telomerase Reverse Transcriptase (TERT) Promoter Mutations in Photodynamic Diagnosis With 5-Aminolevulinic Acid False-Positive Sites in Non-muscle-Invasive Bladder Cancer. [PDF]

Cureus
Saito Y, Adomi S, Sakai K, Antonio De Velasco M, Hashimoto M, Banno E, Hayashi Y, Minami T, Nishio K, Fujita K.   +9 more
europepmc   +1 more source

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice. [PDF]

Aging Cell
Zhu TY, Hu P, Mi YH, Zhang JL, Xu AN, Gao MT, Zhang YY, Shen SB, Yang GM, Pan Y.   +9 more
europepmc   +1 more source

Development of 3D Cell-Based Fluorescent Reporter Assay for Screening of Drugs Downregulating Telomerase Reverse Transcriptase. [PDF]

Bioengineering (Basel)
Li Y, Zhang F, Qin Z, Yang ST.
europepmc   +1 more source

Synthesis of novel N1 functionalized diazepinone analogues <i>via</i> a base-mediated C-N cross coupling reaction as reverse transcriptase inhibitors: theoretical and experimental investigations. [PDF]

RSC Adv
Jaiswal S, Jain S, Mukhija A, Verma K, Jain S, Kishore D, Dwivedi J, Sharma S.   +7 more
europepmc   +1 more source

Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents. [PDF]

ACS Chem Neurosci
Jones T, Raman R, Puhl AC, Lane TR, Riabova O, Kazakova E, Makarov V, Ekins S.   +7 more
europepmc   +1 more source

Association of pre-and postnatal mercury exposure with cardiometabolic risk factors in children: the role of the telomere length and telomerase reverse transcriptase polymorphisms.

Environ Int
Lozano M, Soler-Blasco R, Ballester F, Gutzkow KB, Brantsæter AL, Karachaliou M, Stephanou EG, Symvoulakis EK, Grazuleviciene R, Andrusaityte S, Dedele A, Yang TC, McEachan RRC, Wright J, Heude B, Yuan WL, Vrijheid M, Maitre L, Stratakis N, Thomsen C, Nawrot T, Broberg K, Llop S.   +22 more
europepmc   +1 more source