Results 261 to 270 of about 1,758,180 (373)

A Novel Transcriptional Slippage Mechanism Rescues Dystrophin Expression from a DMD Frameshift Variant

Annals of Neurology, EarlyView.
Pathogenic DMD variants usually follow the reading‐frame rule: out‐of‐frame changes cause Duchenne muscular dystrophy, whereas in‐frame ones produce Becker muscular dystrophy (BMD). We report a 23‐year‐old man with BMD‐like weakness, calf hypertrophy, elevated creatine kinase, and dilated cardiomyopathy.
Hiroya Naruse, Jun Mitsui, Akatsuki Kubota, So Okubo, Shuichiro Mitsuchi, Kensho Sumi, Shuichi Tanifuji, Shogo Komaki, Asuka Kitamura, Meiko Maeda, Daiki Yashita, Atsushi Sudo, Takashi Matsukawa, Masashi Hamada, Wataru Satake, Shoji Tsuji, Tatsushi Toda   +16 more
wiley   +1 more source

Reverse transcriptase inhibitors in Aicardi-Goutières syndrome: A crossover clinical trial. [PDF]

Dev Med Child Neurol
Crow YJ, Briggs TA, Eleftheriou D, Parida A, Battison C, Giddings A, Kennel T, Parker RA, AGS‐RTIs Study Group.   +8 more
europepmc   +1 more source

Quantification of Hepatitis C Virus in Human Liver and Serum Samples by Using LightCycler Reverse Transcriptase PCR

, 2002
Peter A. White, Yong Pan, Anthony Freeman, George Marinos, Rosemary Ffrench, Andrew R. Lloyd, William D. Rawlinson   +6 more
openalex   +1 more source

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

Advanced NanoBiomed Research, EarlyView.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han, Iris S. Weitz, Hasan Slika, Betty Tyler, Andrew J. Steckl   +4 more
wiley   +1 more source

Design, Synthesis, and Biological Activity of Amine-Type Cyclopentanepyridinone Derivatives as HIV‑1 Non-Nucleoside Reverse Transcriptase Inhibitors. [PDF]

ACS Omega
Castro-Perea NV, Rodríguez-Vega G, Abarca-Magaña JC, Ruiz-Rivera MB, Medina-Franco JL, Huerta L, Chávez D.   +6 more
europepmc   +1 more source

Stable Complexes Formed by HIV-1 Reverse Transcriptase at Distinct Positions on the Primer-template Controlled by Binding Deoxynucleoside Triphosphates or Foscarnet

, 2007
Peter R. Meyer, Wiriya Rutvisuttinunt, S. Matsuura, Antero G. So, Walter A. Scott   +4 more
openalex   +1 more source

Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities [PDF]

, 2002
Pradeep K. Pandey, Neerja Kaushik, Kamalendra Singh, Bechan Sharma, Alok Upadhyay, Suriender Kumar, Dylan Harris, Virendra N. Pandey   +7 more
openalex   +1 more source

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

Hepatology, 2014
J. Nault, J. Calderaro, L. di Tommaso, C. Balabaud, E. Zafrani, P. Bioulac-Sage, M. Roncalli, J. Zucman‐Rossi   +7 more
semanticscholar   +1 more source

Association of nucleoside reverse transcriptase inhibitor use with reduced risk of Alzheimer's disease risk. [PDF]

Alzheimers Dement
Magagnoli J, Ambati M, Cummings TH, Nguyen J, Thomas CC, Ambati VL, Sutton SS, Gelfand BD, Ambati J.   +8 more
europepmc   +1 more source

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

Science, 2014
B. Fowler, Bradley D. Gelfand, Younghee Kim, N. Kerur, Valeria Tarallo, Yoshio Hirano, Shoba Amarnath, D. Fowler, M. Radwan, M. Young, K. Pittman, P. Kubes, H. Agarwal, K. Parang, D. Hinton, A. Bastos-Carvalho, Shengjian Li, T. Yasuma, Takeshi Mizutani, Reo Yasuma, Charles B. Wright, J. Ambati   +21 more
semanticscholar   +1 more source