Results 1 to 10 of about 399,014 (392)
Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome [PDF]
New England Journal of Medicine, 2018 ART for the Aicardi–Goutieres Syndrome The genetic encephalopathy Aicardi–Goutieres syndrome is thought to be due to misidentification of self-derived nucleic acids and the induction of a type I in...
Rice, Gillian +38 more
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Investigational reverse transcriptase inhibitors for the treatment of HIV [PDF]
Expert Opinion on Investigational Drugs, 2015 While considerable advances have been made in the development of antiretroviral agents, there is still work to be done. Reverse transcriptase inhibitors are important drugs for the treatment of HIV, and considerable research is currently ongoing to develop new agents and to modify currently existing agents.Herein, the authors discuss both ...
Santosh Kumar +3 more
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Nonnucleoside Reverse Transcriptase Inhibitor Resistance [PDF]
Journal of Acquired Immune Deficiency Syndromes, 2001 Although understanding of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance is less clearly established than that of other classes of antiretroviral drugs, certain facts have been established. The treatment-associated genetic mutation profiles of the available NNRTIs have been mapped, and resistance has been found to develop rapidly ...
Steven G. Deeks
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Reverse Transcriptase Inhibitors as Microbicides
Current HIV Research, 2012 The CAPRISA 004 study in South Africa has accelerated the development of vaginal and rectal microbicides containing antiretrovirals that target specific enzymes in the reproduction cycle of HIV, especially reverse transcriptase inhibitors (RTI). In this review we discuss the potential relevance of HIV-1 RTIs as microbicides, focusing in the nucleotide ...
Lewi, P. +7 more
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Future of nonnucleoside reverse transcriptase inhibitors [PDF]
Proceedings of the National Academy of Sciences, 2018 The nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are small molecules that bind to HIV-1 RT at a site distinct from the DNA polymerase active site of the enzyme and block retroviral reverse transcription via an allosteric mechanism of action (1). Nevirapine (NVP) was the first NNRTI approved in 1996 by the US Food and Drug Administration
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Resistance against Reverse Transcriptase Inhibitors [PDF]
Clinical Infectious Diseases, 2000 The response to antiretroviral therapy in human immunodeficiency virus (HIV)-infected patients is limited by the emergence of drug resistance. This resistance is a consequence of the high rate of HIV mutation, the high rate of viral replication (especially when potent multidrug therapies are not used or taken reliably), and the selective effect of ...
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HIV Reverse Transcriptase Inhibitors of Natural Origin [PDF]
Planta Medica, 1999 Inhibitors of HIV reverse transcriptase (RT) are important drugs for the treatment of acquired immuno-deficiency syndrome (AIDS). One approach to identify novel inhibitors of HIV-1-RT is the screening of natural compounds. Many natural products have been shown to be active as RT inhibitors. These compounds belong to a wide range of different structural
Anthony D. Wright +2 more
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AIDS, 2019 Scale-up of antiretroviral therapy (ART) and introduction of treat-all strategy necessitates population-level monitoring of acquired HIV drug resistance (ADR) and pretreatment drug resistance (PDR) mutations.Blood samples were collected from 4973 HIV-positive individuals residing in 30 communities across Botswana who participated in the Botswana ...
Erik van Widenfelt +20 more
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Reverse Transcriptase Inhibitors as Potential Colorectal Microbicides [PDF]
Antimicrobial Agents and Chemotherapy, 2009 ABSTRACTWe investigated whether reverse transcriptase (RT) inhibitors (RTI) can be combined to inhibit human immunodeficiency virus type 1 (HIV-1) infection of colorectal tissue ex vivo as part of a strategy to develop an effective rectal microbicide.
Carolina Herrera +4 more
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Nucleoside reverse transcriptase inhibitors and HIV mutagenesis [PDF]
Journal of Antimicrobial Chemotherapy, 2003 Potent antiretroviral therapy (ART) of HIV-1 infection with anti-retroviral drugs consisting of nucleoside reverse transcriptase inhibitors(NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs)and protease inhibitors (PIs) has dramatically reduced the rate ofHIV- and AIDS-related morbidity and mortality. The lack of patientcompliance to drug
Raquel M. Raices +3 more
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