Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens [PDF]
mBioBacterial infections can induce exuberant immune responses that can damage host tissues. Previously, we demonstrated that systemic Escherichia coli infection in mice causes tissue damage in the liver. This liver necrosis is associated with the expression
Karthik Hullahalli +5 more
doaj +2 more sources
Approved HIV reverse transcriptase inhibitors in the past decade [PDF]
Acta Pharmaceutica Sinica B, 2022 HIV reverse transcriptase (RT) inhibitors are the important components of highly active antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in clinical practice.
Guangdi Li, Yali Wang, Erik De Clercq
doaj +2 more sources
HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors [PDF]
Virology JournalThe human T-lymphotropic virus type 1 (HTLV-1) infects millions of people globally and is endemic to various resource-limited regions. Infections persist for life and are associated with increased susceptibility to opportunistic infections and severe ...
Nicolas Tardiota +4 more
doaj +2 more sources
Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors. [PDF]
Acta Pharm Sin BChen XM +5 more
europepmc +2 more sources
Liver Damage During Treatment with Reverse-Transcriptase Inhibitors in HIV Patients. [PDF]
Curr Health Sci JLungu GN +7 more
europepmc +3 more sources
Cost-effectiveness of the third-agent class in treatment-naive human immunodeficiency virus-infected patients in Portugal. [PDF]
PLoS ONE, 2012 IntroductionCurrent Portuguese HIV treatment guidelines recommend initiating antiretroviral therapy with a regimen composed of two Nucleoside Reverse Transcriptase Inhibitors plus one Non-nucleoside Reverse Transcriptase Inhibitor (2NRTI+NNRTI) or two ...
Filipa Aragão +2 more
doaj +1 more source
In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs. [PDF]
PLoS ONE, 2012 Telomerase is a specialized reverse transcriptase responsible for the de novo synthesis of telomeric DNA repeats. In addition to its established reverse transcriptase and terminal transferase activities, recent reports have revealed unexpected cellular ...
Kyle R Hukezalie +3 more
doaj +1 more source
Capacity of rTth polymerase to detect RNA in the presence of various inhibitors. [PDF]
PLoS ONE, 2018 The full potential of the real-time reverse transcription polymerase chain reaction (RT-PCR) as a rapid and accurate diagnostic method is limited by DNA polymerase inhibitors as well as reverse transcriptase inhibitors which are ubiquitous in clinical ...
Dongyang Cai +4 more
doaj +1 more source
Reverse Transcriptase Inhibitors as Microbicides
Current HIV Research, 2012 The CAPRISA 004 study in South Africa has accelerated the development of vaginal and rectal microbicides containing antiretrovirals that target specific enzymes in the reproduction cycle of HIV, especially reverse transcriptase inhibitors (RTI). In this review we discuss the potential relevance of HIV-1 RTIs as microbicides, focusing in the nucleotide ...
Lewi, P. +7 more
openaire +5 more sources
Bangabandhu Sheikh Mujib Medical University Journal, 2016 Retinol molecule was modified to predict the inhibitors of telomerase reverse transcriptase for the treatment of arsenical cancer through in silico study. Telomerase activity is expressed in the cancerous conditions which can be the target for anticancer
Kipchu Tshering, Mir Misbahuddin
doaj +1 more source