Results 151 to 160 of about 399,014 (392)
Advanced Science, EarlyView.This study demonstrates that the miRNA pathway plays a key role in the invasive growth of Alternanthera philoxeroides in aquatic habitats. Specifically, miR162 is critical for its invasive success, facilitating stem elongation and enhancing survival during submergence.
Qianqian Hu +8 more
wiley +1 more source
Podoscyphic Acid, A New Inhibitor Of Avian Myeloblastosis Virus And Moloney Murine Leukemia Virus Reverse Transcriptase From A Podoscypha Species [1] [PDF]
, 1991 Gerhard Erkel +3 more
openalex +1 more source
Advanced Science, EarlyView.It is shown that obesity is associated with increases in hepatic METTL14 and m6A methylation of G6pc transcript. YTHDF1 and YTHDF3 bind to m6A‐marked G6pc mRNA to increase its synthesis. Hepatocyte‐specific deletion of Mettl14 decreases G6pc m6A methylation, G6pc biosynthesis, and G6pc‐mediated gluconeogenesis, alleviating glucose metabolic defects in ...
Qiantao Zheng +6 more
wiley +1 more source
Advanced Science, EarlyView.A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li +21 more
wiley +1 more source
HIV versus the Terminator: Drug resistance of HIV reverse transcriptase with mutations at the connection subdomain [PDF]
, 2008 only availableAntiretroviral drug therapy can prolong the life of an HIV-infected individual, but this treatment also promotes drug-resistance mutations.
Jackson, Jacob C. +2 more
core
Journal of the International AIDS Society, 2016 Introduction As availability of antiretroviral therapy expands in developing countries, the risk for transmission of drug‐resistant HIV also increases. Patients with acute HIV infection (AHI) provide an opportunity for real‐time monitoring of transmitted
Donn J Colby +13 more
doaj +1 more source
Antiviral Resistance of Biologic HIV-2 Clones Obtained From Individuals on Nucleoside Reverse Transcriptase Inhibitor Therapy [PDF]
, 2000 Me Vanderende +6 more
openalex +2 more sources
Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +9 more
wiley +1 more source
Protease inhibitors: A new weapon and a new strategy against HIV [PDF]
, 1996 Until recently, reverse transcriptase inhibitors have been the mainstay for treating HIV infection. Now, three protease inhibitors have been approved. Early evidence suggests that triple therapy delays the progression of HIV infection.
Phillips, Kenneth D.
core +1 more source
Antiviral Activity of the Human Immunodeficiency Virus Type 1–Specific Nonnucleoside Reverse Transcriptase Inhibitor HBY 097 Alone and in Combination with Zidovudine in a Phase II Study [PDF]
, 1999 Jőrg‐Peter Kleim +8 more
openalex +1 more source