Results 11 to 20 of about 399,014 (392)

Approved HIV reverse transcriptase inhibitors in the past decade. [PDF]

Acta Pharm Sin B, 2022
HIV reverse transcriptase (RT) inhibitors are the important components of highly active antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in clinical practice.
Li G, Wang Y, De Clercq E.
europepmc   +3 more sources

Focus on chirality of HIV-​1 non-​nucleoside reverse transcriptase inhibitors [PDF]

Molecules, 2016
Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug resistant mutant strains.
Famiglini, Valeria, Silvestri, Romano
core   +5 more sources

In silico prediction of telomerase reverse transcriptase inhibitors using modified retinol for the treatment of arsenical cancer [PDF]

Bangabandhu Sheikh Mujib Medical University Journal, 2016
Retinol molecule was modified to predict the inhibitors of telomerase reverse transcriptase for the treatment of arsenical cancer through in silico study. Telomerase activity is expressed in the cancerous conditions which can be the target for anticancer
Misbahuddin, Mir, Tshering, Kipchu
core   +4 more sources

Islatravir Has a High Barrier to Resistance and Exhibits a Differentiated Resistance Profile from Approved Nucleoside Reverse Transcriptase Inhibitors (NRTIs). [PDF]

Antimicrob Agents Chemother, 2022
Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) that inhibits human immunodeficiency virus (HIV) reverse transcription by blocking reverse transcriptase (RT) translocation on the primer:template.
Diamond TL, Ngo W, Xu M, Goh SL, Rodriguez S, Lai MT, Asante-Appiah E, Grobler JA.   +7 more
europepmc   +2 more sources

Prevalence of genotypic HIV-1 drug resistance in Thailand, 2002 [PDF]

Annals of Clinical Microbiology and Antimicrobials, 2003
BACKGROUND: The prices of reverse transcriptase (RT) inhibitors in Thailand have been reduced since December 1, 2001. It is expected that reduction in the price of these inhibitors may influence the drug resistance mutation pattern of HIV-1 among ...
Chantratita, Wasun, Jenwitheesuk, Ekachai, Vibhagool, Asda, Watitpun, Chotip   +3 more
core   +5 more sources

Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens. [PDF]

mBio
Bacterial infections can induce exuberant immune responses that can damage host tissues. Previously, we demonstrated that systemic Escherichia coli infection in mice causes tissue damage in the liver. This liver necrosis is associated with the expression
Hullahalli K, Dailey KG, Acbay R, Suzuki M, Balazs GI, Waldor MK.   +5 more
europepmc   +2 more sources

In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs. [PDF]

PLoS ONE, 2012
Telomerase is a specialized reverse transcriptase responsible for the de novo synthesis of telomeric DNA repeats. In addition to its established reverse transcriptase and terminal transferase activities, recent reports have revealed unexpected cellular ...
Kyle R Hukezalie, Naresh R Thumati, Hélène C F Côté, Judy M Y Wong   +3 more
doaj   +2 more sources

The “Connection” Between HIV Drug Resistance and RNase H [PDF]

Viruses, 2010
Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target the
Arts, Dau, di Marzo Veronese, Friedman-Kien, Galina N. Nikolenko, Gopalakrishnan, Gupta, Johnson, Johnson, Kemp, Kohlstaedt, Krista A. Delviks-Frankenberry, Naeger, Nikolenko, Perno, Quagliarello, Tachedjian, Telesnitsky, Upadhyay, Vinay K. Pathak, Volkmann, Waters, Yahi   +22 more
core   +5 more sources

Twenty-six years of HIV science: an overview of anti-HIV drugs metabolism [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2011
From the identification of HIV as the agent causing AIDS, to the development of effective antiretroviral drugs, the scientific achievements in HIV research over the past twenty-six years have been formidable.
Andrade, Carolina Horta, Freitas, Lenis Medeiros de, Oliveira, Valéria de   +2 more
core   +7 more sources

Design of structure-based reverse transcriptase inhibitors.

Journal of Biological Chemistry, 1994
Based on the crystallographic structure of the active site in the reverse transcriptase (RT) of human immunodeficiency virus (HIV), a group of hydrophobic polyadenylic acid (5') derivatives were designed and synthesized as inhibitors of the enzyme. These compounds were found to inhibit all six of the RTs tested, with IC50 = 10(-11)-10(-8) M, but did ...
Insung Kang, Jiyao Wang
openaire   +4 more sources