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Pharmacokinetics of Reverse Transcriptase Inhibitors
2007The nucleoside reverse transcriptase inhibitors (NRTIs) were the first class of compounds discovered to be potent inhibitors of HIV replication (1 and, to date, these drugs remain the backbone of antiretroviral therapy. NRTIs are essentially prodrugs, inactive in their parent form and requiring activation to exert their antiviral effects (2, 3).
Patrick Hoggard +3 more
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Coumarins as Inhibitors of HIV Reverse Transcriptase
Current HIV Research, 2006Acquired immunodeficiency syndrome (AIDS), a degenerative disease of the immune and central nervous systems, is an enormous world-wide health threat. No cure has been found, and research is aimed at developing chemotherapy against the causative agent, human immunodeficiency virus (HIV).
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Quinolinehydrazones as inhibitors of retroviral reverse transcriptase.
Farmaco (Societa chimica italiana : 1989), 1992The inhibitory activity of a series of 2- and 4-quinolinehydrazones on retroviral reverse transcriptase has been studied on enzymes from M-MuLV, RAV-2, and on a crude lysate of HIV-1, assuming the first two enzymes as potential models of the third. The highest activity is mainly found in lipophilic, water soluble 4-quinolinehydrazones.
C. Bartolucci +7 more
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Nucleoside reverse transcriptase inhibitors/nucleotide reverse transcriptase inhibitors
Reactions Weekly, 2019openaire +1 more source
Use of nonnucleoside reverse-transcriptase inhibitors
American Journal of Health-System Pharmacy, 1998C D, Holtzer, R L, Coleman
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Specific HIV-1 Reverse Transcriptase Inhibitors
Journal of Enzyme Inhibition, 1992Z, Debyser +3 more
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