Results 121 to 130 of about 8,159 (227)
Identification of the Role of P-Rex1 and its Adaptor Functions in Neutrophils
P-Rex1 is a guanine-nucleotide exchange factor (Rac-GEF) for the small GTPase Rac, recognised for its involvement in neutrophil migration and ROS generation in response to GPCR activation—functions traditionally attributed to its Rac-GEF activity. Additionally, previous findings from our laboratory demonstrated a GEF-independent role for P-Rex1 in GPCR
Islam, Priota
openalex +2 more sources
Neotropical IchthyologyThe transposable elements (TE) have been widely applied as physical chromosome markers. However, in Loricariidae there are few physical mapping analyses of these elements.
Josiane B. Traldi +6 more
doaj +1 more source
Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets
Journal of Molecular Signaling, 2011 Blood platelets undergo a carefully regulated change in shape to serve as the primary mediators of hemostasis and thrombosis. These processes manifest through platelet spreading and aggregation and are dependent on platelet actin cytoskeletal changes orchestrated by the Rho GTPase family member Rac1.
Aslan, Joseph E +6 more
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Rac Activation: P-Rex1 — A Convergence Point for PIP3 and Gβγ? [PDF]
Current Biology, 2002 AbstractP-Rex1, a novel Rac activator, has been identified in the first biochemical purification of a guanine nucleotide exchange factor for GTPases of the Rho family. P-Rex1 is synergistically activated by PIP3 and Gβγ and may act as a coincidence detector for these signaling molecules.
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A model-based analysis of culture-dependent phenotypes of mESCs.
PLoS ONE, 2014 Mouse embryonic stem cells (mESCs) can be maintained in a proliferative and undifferentiated state over many passages (self-renewal) while retaining the potential to give rise to every cell type of the organism (pluripotency).
Maria Herberg +4 more
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THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation
Stem Cell Reports, 2017 THAP1 (THAP [Thanatos-associated protein] domain-containing, apoptosis-associated protein 1) is a ubiquitously expressed member of a family of transcription factors with highly conserved DNA-binding and protein-interacting regions.
Francesca Aguilo +14 more
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NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State
Stem Cell Reports, 2017 Naive mouse embryonic stem cells (ESCs) can develop multiple fates, but the cellular and molecular processes that enable lineage competence are poorly characterized. Here, we investigated progression from the ESC ground state in defined culture.
Carla Mulas, Tüzer Kalkan, Austin Smith
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P‐Rex1 is critical for vascular hyper‐permeability and edema in the lungs
The FASEB Journal, 2012 The primary objective of this study was to investigate a role for P‐Rex1 (PIP3 dependent Rac exchanger 1) a guanine nucleotide exchange factor for Rac, previously known for G protein‐coupled receptor signaling, in mediating TNF‐α‐induced vascular hyper‐permeability.
Ram Prasad Naikawadi +5 more
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MOF-associated complexes ensure stem cell identity and Xist repression
eLife, 2014 Histone acetyl transferases (HATs) play distinct roles in many cellular processes and are frequently misregulated in cancers. Here, we study the regulatory potential of MYST1-(MOF)-containing MSL and NSL complexes in mouse embryonic stem cells (ESCs) and
Tomasz Chelmicki +12 more
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Worst-case Optimal Query Answering for Greedy Sets of Existential Rules and Their Subclasses
, 2014 The need for an ontological layer on top of data, associated with advanced reasoning mechanisms able to exploit the semantics encoded in ontologies, has been acknowledged both in the database and knowledge representation communities.
Baget, Jean-François +3 more
core +1 more source