Results 181 to 190 of about 44,129 (257)

Calycosin-7-O-β-D-Glucoside Facilitates Axonal Regrowth and Functional Recovery via Rho/ROCK Pathway Inhibition After Cerebral Ischemia/Reperfusion. [PDF]

Int J Mol Sci
Wang P, Yu A, Liang Y, Wang L.
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Rho/ROCK Pathway as a Therapeutic Target in Multiple Diseases. [PDF]

Int J Drug Discov Pharm
Cheng Z, Erhardt S, Wang J.
europepmc   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Pan-cancer signaling landscape linked to endothelial and immune Sphingosine-1-phosphate receptor 1 (S1PR1) expression. [PDF]

In Silico Pharmacol
Torres-Santos Y, Beltrán-Navarro YM, Reyes-Cruz G, Vázquez-Prado J.   +3 more
europepmc   +1 more source

Musculoskeletal and physiological responses to vortex wave stimulation in older adults

The Journal of Physiology, EarlyView.
Abstract figure legend We explored the acute physiological effects of a novel mechanical stimulus, vortex wave stimulation (VWS), in healthy older adults. Using deuterated water and serial skeletal muscle biopsies, we showed that VWS elevated integrated rates of myofibrillar, but not sarcoplasmic muscle protein synthesis, with no changes observed in ...
Alexander Waddell, Marie Korzepa, Archie E. Belfield, Ben Fry, Rickson C Mesquita, David Smith, Jonathan Quinlan, Leigh Breen   +7 more
wiley   +1 more source

Clostridioides difficile TcdB induces expression of its receptor (CSPG4) through a noncanonical Hippo signaling mechanism. [PDF]

J Biol Chem
Larabee JL, Donald EJ, Sukhadia AA, Shadid TM, Miller SJ, Ballard JD.   +5 more
europepmc   +1 more source

Regulation of platelet contractility by agonists present across a thrombus. [PDF]

Blood Adv
Hiebner DW, Patil S, Kenny M, Baumann J, Mullin F, Benn S, Lickert S, Vogel V, Bender M, Schoen I.   +9 more
europepmc   +1 more source

Differential expression of TKS4 isoforms and their role in cellular processes in breast cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
TKS4 isoforms are differentially expressed across human cell lines. TKS4L interacts with six novel SRC homology 3‐containing proteins, whereas no interactions were detected for TKS4b. SRC‐mediated phosphorylation promotes interactions of TKS4 with SH2 domains.
Serhii Kropyvko, Nazar Shevchuk, Olga Gubar, Kyrylo Lavrynenko, Yaroslav Nemesh, Denys Kozakov, Valentyn Polishchuk, Valentyna Kryklyva, Liubov Syvak, Nataliia Verovkina, Tetyana Gryaznova   +10 more
wiley   +1 more source

Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility. [PDF]

Proc Natl Acad Sci U S A
Tršelič T, Pelo N, Martin de Fremont G, Iyer VS, Richardsdotter Andersson E, Ottosson V, Frei DA, Baas E, Nyberg WA, Thorlacius GE, Mentlein L, Boddul SV, Sandu I, Velasquez Pulgarin D, Végvári Á, Gerlach C, Wermeling F, Sunnerhagen M, Wallner B, Espinosa A, Wahren-Herlenius M.   +20 more
europepmc   +1 more source