Results 211 to 220 of about 44,129 (257)

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

Bioorganic & Medicinal Chemistry Letters, 2009
A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.
Yan, Yin, Li, Lin, Claudia, Ruiz, Michael D, Cameron, Jennifer, Pocas, Wayne, Grant, Thomas, Schröter, Weimin, Chen, Derek, Duckett, Stephan, Schürer, Philip, Lograsso, Yangbo, Feng   +11 more
openaire   +2 more sources

Rho-associated coiled-coil containing kinases (ROCK) [PDF]

Small GTPases, 2014
Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase. (1)(-) (5) They belong to the AGC family of serine/threonine kinases (6) and play vital roles in facilitating actomyosin cytoskeleton contractility downstream of RhoA and RhoC activation.
Linda Julian, Michael F Olson
exaly   +3 more sources

Rho-Associated Kinases in Cerebrovascular Disease

2017
Abstract The Rho/Rho kinase (ROCK) pathway is a key molecular switch for many diverse cellular processes implicated in increasing the risk and worsening the outcome of cerebrovascular diseases including acute ischemic or hemorrhagic stroke, as well as chronic cerebrovascular dysfunction.
H.-H. Kim, C. Ayata
openaire   +1 more source

Rho-associated kinase inhibitors: A novel glaucoma therapy

Progress in Retinal and Eye Research, 2013
The rho-associated kinase (ROCK) signaling pathway is activated via secreted bioactive molecules or via integrin activation after extracellular matrix binding. These lead to polymerization of actin stress fibers and formation of focal adhesions. Accumulating evidence suggests that actin cytoskeleton-modulating signals are involved in aqueous outflow ...
Toshihiro, Inoue, Hidenobu, Tanihara
openaire   +2 more sources

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

Science, 1996
The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP⋅RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase,
K, Kimura, M, Ito, M, Amano, K, Chihara, Y, Fukata, M, Nakafuku, B, Yamamori, J, Feng, T, Nakano, K, Okawa, A, Iwamatsu, K, Kaibuchi   +11 more
openaire   +2 more sources

Phosphorylation of Rho-associated kinase (Rho-kinase/ROCK/ROK) substrates by protein kinases A and C

Biochimie, 2007
Rho-associated kinase (Rho-kinase/ROCK/ROK) is a serine/threonine kinase and plays an important role in various cellular functions. The cAMP-dependent protein kinase (protein kinase A/PKA) and protein kinase C (PKC) are also serine/threonine kinases, and directly and/or indirectly take part in the signal transduction pathways of Rho-kinase.
Jeong-Hun Kang, Riki Toita, Takuro Niidome   +2 more
exaly   +3 more sources

Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system

Journal of Hypertension, 2016
In past decades, growing evidence from basic and clinical researches reveal that small guanosine triphosphate binding protein ras homolog gene family, member A (RhoA) and its main effector Rho-associated kinase (ROCK) play central and complex roles in cardiovascular systems, and increasing RhoA and ROCK activity is associated with a broad range of ...
Anping, Cai, Liwen, Li, Yingling, Zhou
openaire   +2 more sources

Rho-Associated Kinase Phosphorylates MARCKS in Human Neuronal Cells

Biochemical and Biophysical Research Communications, 2001
Myristoylated alanine-rich C kinase substrate (MARCKS) is a filamentous actin bundling protein and has multiple sites for phosphorylation, by which the biochemical function is negatively regulated. However, the role of such phosphorylation in physiological functions, particularly in neuronal functions, is not well understood.
H, Nagumo, M, Ikenoya, K, Sakurada, K, Furuya, T, Ikuhara, H, Hiraoka, Y, Sasaki   +6 more
openaire   +2 more sources

The Prototype Rho-Associated Kinase PAK

2005
p21-activated kinase (PAK) was the first identified serine/threonine protein kinase to bind and be activated by Rho GTPases. Since it was discovered some 10 years ago, PAK has been intensively studied and represents the best understood of the Rho-associated kinases.
openaire   +1 more source

Epigenetic Control of Rho-Associated Protein Kinase 2 in Neurodegeneration

Journal of Alzheimer’s Disease, 2019
Upregulation of Rho-associated protein kinase 2 (ROCK2) hallmarks the progression of neurodegenerative diseases. However, the molecular mechanisms underlying the regulation of ROCK2 expression are not clear and thus addressed in the current study.
Bing, Chen, Weiming, Zheng
openaire   +2 more sources