Results 221 to 230 of about 44,129 (257)

Regulation of T-type calcium channels by Rho-associated kinase

Nature Neuroscience, 2007
We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, whereas Ca(v)3.2 currents showed ...
Mircea, Iftinca, Jawed, Hamid, Lina, Chen, Diego, Varela, Reza, Tadayonnejad, Christophe, Altier, Ray W, Turner, Gerald W, Zamponi   +7 more
openaire   +2 more sources

Advances in the development of Rho-associated protein kinase (ROCK) inhibitors

Drug Discovery Today, 2013
Rho-associated protein kinases (ROCK1 and ROCK2) belong to the AGC family of serine-threonine kinases, and regulate a wide range of fundamental cell functions. Inhibition of ROCK has been proven to be of potential therapeutic benefit for a variety of diseases. In this review, the structures and therapeutic importance of ROCK are discussed briefly. Then,
Peichen, Pan, Mingyun, Shen, Huidong, Yu, Youyong, Li, Dan, Li, Tingjun, Hou   +5 more
openaire   +2 more sources

Rho-associated coiled-coil kinase (ROCK) signaling and disease

Critical Reviews in Biochemistry and Molecular Biology, 2013
The small Rho GTPase family of proteins, encompassing the three major G-protein classes Rho, Rac and cell division control protein 42, are key mitogenic signaling molecules that regulate multiple cancer-associated cellular phenotypes including cell proliferation and motility.
Alice V, Schofield, Ora, Bernard
openaire   +2 more sources

Rho-Associated Kinase Inhibitors: Evolving Strategies in Glaucoma Treatment

Drugs, 2019
Glaucoma, a group of progressive optic neuropathies with similar patterns of tissue loss, is primarily treated with medical therapy, followed by laser therapy and, later, incisional surgery. Aside from the introduction of prostaglandin analogs, topical carbonic anhydrase inhibitors, and topical alpha-agonists in the 1990s, no new pharmaceutical agents ...
Emily M, Schehlein, Alan L, Robin
openaire   +2 more sources

RHO-ASSOCIATED KINASE MODULATES MYOCARDIAL INFLAMMATORY CYTOKINE RESPONSES

Shock, 2005
Rho, a Ser-Thr kinase identified as a member of the RAS GTPase super family, is highly expressed in the heart, and has been implicated in the development of heart failure. GTPase Rho is located downstream of Gq, and Rho and the associated kinase (Rho kinase) regulate myofibril organization, apoptosis, and myofibrillar sensitivity to calcium. Myocardial
Jureta W, Horton, David L, Maass, Cherry, Ballard-Croft   +2 more
openaire   +2 more sources

Elongation Factor-1α Is a Novel Substrate of Rho-Associated Kinase

Biochemical and Biophysical Research Communications, 2000
Rho-associated kinase (Rho-kinase), which is activated by the Rho small GTPase, phosphorylates the myosin-binding subunit (MBS) of myosin phosphatase, myosin light chain (MLC), the ERM family proteins, and adducin, thereby regulating the formation of stress fibers, focal adhesions, microvillus formation, and cell motility.
T, Izawa, Y, Fukata, T, Kimura, A, Iwamatsu, K, Dohi, K, Kaibuchi   +5 more
openaire   +2 more sources

Rho-Associated Kinase: Involvement in the Cytoskeleton Regulation

Archives of Biochemistry and Biophysics, 1999
openaire   +2 more sources

Rho family GTPase signaling through type II p21-activated kinases

Cellular and Molecular Life Sciences, 2022
Ashwin Kanna Chetty, Titus Boggon, Byung Hak Ha   +2 more
exaly  

Rho-Associated Kinase

2018
openaire   +1 more source

Rho Kinases in Cardiovascular Physiology and Pathophysiology

Circulation Research, 2006
Gervaise Loirand, Patrice Guerin, Pierre Pacaud   +2 more
exaly