Results 101 to 110 of about 57,806 (244)

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

Journal of Biological Chemistry, 1994
GTP-binding proteins of the Rho family are maintained as cytosolic complexes with RhoGDI in resting cells, but are released and translocate to the membrane during the course of cell activation. Membrane association of Rac/Rho/CDC42 was specifically induced by GTP analogs and required a heat- and trypsin-labile membrane component.
G M, Bokoch, B P, Bohl, T H, Chuang
openaire   +2 more sources

Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. [PDF]

, 2004
Insulin stimulation of adipocytes resulted in the recruitment of atypical PKC (PKCzeta/lambda) to plasma membrane lipid raft microdomains. This redistribution of PKCzeta/lambda was prevented by Clostridium difficile toxin B and by cholesterol depletion ...
Hwang, Joseph B, Kanzaki, Makoto, Mora, Silvia, Pessin, Jeffrey E, Saltiel, Alan R   +4 more
core   +1 more source

RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]

, 2018
Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre, Anselme, Aravind, Beales, Bergen, Berger, Berson, Billaud, Burnside, Burridge, Cahalan, Carroll, Chapman, Cossart, Ferreira, Ferreira, Fuchs, Habas, He, Hildebrandt, Hogan, Imanishi, Jacobson, Johnson, Kaibuchi, Katsanis, Kaykas, Kelley, Khaliq, Khanna, Khanna, Kroes, Lewis, Li, Li, Li, MacDonald, MacDonald, Meyer, Mitchell, Nelson, Nishina, Nusse, Prevarskaya, Putney, Ridley, Roepman, Rosado, Rüther, Rüther, Sage, Schermer, Schneider-Maunoury, Shu, Stainier, Tolwinski, Torban, Vaudin, Vervoort, Vesque, Wallingford, Wittinghofer, Wolfrum, Wright, Wright, Wright, Wright, Wright, Zrenner   +68 more
core   +3 more sources

Linking Superoxide Production and Scavenging in Plant Development

Plant, Cell &Environment, EarlyView.
ABSTRACT Due to their strong oxidizing potential, rapid membrane permeability, and high reactivity, reactive oxygen species (ROS) play essential roles in plant development and stress responses. Superoxide (O2•‐) is a primary product of molecular oxygen reduction and a crucial source of hydrogen peroxide, representing a ROS species of substantial ...
Jan Řehák, Maryna Tsinyk, Petr Dvořák, Tomáš Takáč   +3 more
wiley   +1 more source

Role of Phospholipase D in G-Protein Coupled Receptor Function

Membranes, 2014
Prolonged agonist exposure of many G-protein coupled receptors induces a rapid receptor phosphorylation and uncoupling from G-proteins. Resensitization of these desensitized receptors requires endocytosis and subsequent dephosphorylation.
Lars-Ove Brandenburg, Thomas Pufe, Thomas Koch   +2 more
doaj   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. [PDF]

PLoS ONE, 2010
The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative effector protein of urogenital C. trachomatis serovars, with the N-terminal glucosyltransferase domain
Jessica Thalmann, Katrin Janik, Martin May, Kirsten Sommer, Jenny Ebeling, Fred Hofmann, Harald Genth, Andreas Klos   +7 more
doaj   +1 more source

Regulation of Cdc42 for polarized growth in budding yeast

Microbial Cell, 2020
The Rho GTPase Cdc42 is a central regulator of cell polarity in diverse cell types. The activity of Cdc42 is dynamically controlled in time and space to enable distinct polarization events, which generally occur along a single axis in response to spatial
Kristi E. Miller, Pil Jung Kang, Hay-Oak Park   +2 more
doaj   +1 more source

Functional specialization of the yeast Rho1 GTP exchange factors [PDF]

, 2012
Rho GTPases are regulated in complex spatiotemporal patterns that may be dependent, in part at least, on the multiplicity of their GTP exchange factors (GEFs).
Cundell, M., Gray, J., Johnston, G., Krause, S., McGhie, J., Poon, P., Price, C.   +6 more
core  

Baishaoluoshi Decoction Mitigates Post‐Stroke Spasticity by Targeting Synaptic Plasticity Through the Nogo‐A/NgR Signaling Pathway

Brain and Behavior, Volume 16, Issue 1, January 2026.
Baishaoluoshi Decoction alleviates post‐stroke spasticity by downregulating inhibitory proteins (Nogo‐A/NgR) in the peri‐infarct brain region and reducing NgR/Olig2 co‐localization in oligodendrocytes, thereby enhancing synaptic plasticity. ABSTRACT Objective: This study systematically investigated the effects and molecular mechanisms of Baishaoluoshi ...
Xiongxing Sun, Shanshan Zeng, Shigao Lin, Lingying Wu, Xukun Tang, Jiajian Zhu, Yuhui Zhang, Lu Li, Ziming Chen, Xinyu Deng, Dahua Wu, Le Xie   +11 more
wiley   +1 more source