Uptake of Clostridium botulinum C3 Exoenzyme into Intact HT22 and J774A.1 Cells
Toxins, 2015 The Clostridium botulinum C3 exoenzyme selectively ADP-ribosylates low molecular weight GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling activity, resulting in distinct actin cytoskeleton changes.
Astrid Rohrbeck +3 more
doaj +1 more source
A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis. [PDF]
The Journal of cell biology, 1996 Several members of the rho/rac family of small GTP-binding proteins are known to regulate the distribution of the actin cytoskeleton in various subcellular processes. We describe here a novel rac protein, racE, which is specifically required for cytokinesis, an actomyosin-mediated process.
A De Lozanne +2 more
openaire +3 more sources
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. [PDF]
, 2001 Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the ...
Chiang, SH +7 more
core +3 more sources
Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and small Rho-family GTPases [PDF]
, 2017 Collective cell migration is a hallmark of developmental and patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding epithelial sheets can be influenced by extracellular cues, including cell-cell and cell-matrix interactions.
arxiv +1 more source
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters [PDF]
In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours.
Bahlmann, F +4 more
core +2 more sources
Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency [PDF]
, 2004 Although most components of the mitochondrial translation apparatus are encoded by nuclear genes, all known molecular defects associated with impaired mitochondrial translation are due to mutations in mitochondrial DNA.
Antonicka, H +10 more
core +2 more sources
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Role of Phospholipase D in G-Protein Coupled Receptor Function
Membranes, 2014 Prolonged agonist exposure of many G-protein coupled receptors induces a rapid receptor phosphorylation and uncoupling from G-proteins. Resensitization of these desensitized receptors requires endocytosis and subsequent dephosphorylation.
Lars-Ove Brandenburg +2 more
doaj +1 more source
Implementation of the Spherical Coordinate Representation of Protein 3D Structures and its Applications Using FORTRAN 77/90 Language [PDF]
arXiv, 2015 We previously described the representation of protein 3D structures in spherical coordinates (rho, phi, theta) and two of its applications: separation of the outer layer (OL) from the inner core (IC) of proteins, and assessment of protein surface protrusions and invaginations (Reyes, V.M., 2011& 2009).
arxiv
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel +11 more
wiley +1 more source