Results 51 to 60 of about 82,160 (288)
Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from G{alpha}12/13 and G{alpha}11/q [PDF]
The Journal of Biological Chemistry 283, 44 (2008) 29888-96, 2008 Increase in vascular permeability occurs under many physiological conditions and is central in diverse human pathologies. Thrombin is a pro-coagulant serine protease, which causes the local loss of endothelial barrier integrity thereby enabling the rapid extravasation of plasma proteins and the local formation of fibrin-containing clots.
arxiv +1 more source
Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis [PDF]
, 2016 RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ...
Ji, Wei, Rivero, Francisco
core +2 more sources
Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function [PDF]
Journal of Biological Chemistry, 1995 The lbc oncogene is tumorigenic in nude mice, transforms NIH 3T3 fibroblasts, and encodes a Dbl homology domain found in several transforming gene products including the dbl oncogene product. While both lbc- and dbl-transformed NIH 3T3 foci exhibited a comparable gross appearance, lbc-transformed cell morphology was clearly distinct from that of dbl ...
Yi Zheng +4 more
openaire +2 more sources
The role of statins in lung cancer
Archives of Medical Science, 2021 Lung cancer is one of the most common causes of cancer-related mortality in the 21st century. Statins as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase not only reduce the cholesterol levels in the blood and decrease the risk of ...
Fatemeh Amin +4 more
doaj +1 more source
Spectral Analysis and the Dynamic Response of Complex Networks [PDF]
Phys. Rev. E71 (2005) 16106, 2004 The eigenvalues and eigenvectors of the connectivity matrix of complex networks contain information about its topology and its collective behavior. In particular, the spectral density $\rho(\lambda)$ of this matrix reveals important network characteristics: random networks follow Wigner's semicircular law whereas scale-free networks exhibit a ...
arxiv +1 more source
Rho: theme and variations [PDF]
, 1996 In addition to their roles in organizing the actin cytoskeleton, members of the Rho family of GTP-binding proteins have recently been implicated in a plethora of other functions, including the activation of kinase cascades and transcription factors, and ...
Ridley, Anne J.
core +1 more source
European Journal of Cell Biology, 2023 Small GTPases are highly regulated proteins that control essential signaling pathways through the activity of their effector proteins. Among the RHOA subfamily, RHOB regulates peculiar functions that could be associated with the control of the endocytic ...
Sebastian Castillo +11 more
doaj
The Small GTP-Binding Protein Rho Potentiates AP-1 Transcription in T Cells [PDF]
Molecular and Cellular Biology, 1998 The Rho family of small GTP-binding proteins is involved in the regulation of cytoskeletal structure, gene transcription, specific cell fate development, and transformation. We demonstrate in this report that overexpression of an activated form of Rho enhances AP-1 activity in Jurkat T cells in the presence of phorbol myristate acetate (PMA), but ...
Steven J. Burakoff +4 more
openaire +3 more sources
A novel partner for the GTP-bound forms of rho and rac [PDF]
, 1995 Using the yeast two hybrid system and overlay assays we identified a putative rho/rac effector, citron, which interacts with the GTP-bound forms of rho and rac1, but not with cdc42. Extensive homologies to known proteins were not observed.
Furuyashiki, Tomoyuki +6 more
core +1 more source
eJHaem, 2021 RhoH is an unusual member of the Rho family of small GTP‐binding proteins in that it lacks GTPase activity. Since the RhoH protein is constantly bound by GTP, it is constitutively active and controlled predominantly by changes in quantitative expression.
Sylvie Galiègue‐Zouitina +9 more
doaj +1 more source