Results 141 to 150 of about 42,798 (278)

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Mechanosensitive stem cell fate choice is instructed by dynamic fluctuations in activation of Rho GTPases. [PDF]

Proc Natl Acad Sci U S A, 2023
Sampayo RG, Sakamoto M, Wang M, Kumar S, Schaffer DV.   +4 more
europepmc   +1 more source

Ect2/Pbl Acts via Rho and Polarity Proteins to Direct the Assembly of an Isotropic Actomyosin Cortex upon Mitotic Entry.

, 2015
Entry into mitosis is accompanied by profound changes in cortical actomyosin organization. Here, we delineate a pathway downstream of the RhoGEF Pbl/Ect2 that directs this process in a model epithelium.
Rosa, André, Pichaud, Franck, Vlassaks, E, Baum, B, Pichaud, F, Rosa, A, Vlassaks, Evi, Baum, Buzz   +7 more
core   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases. [PDF]

Nat Commun, 2023
Cheng X, Barakat R, Pavani G, Usha MK, Calderon R, Snella E, Gorden A, Zhang Y, Gadue P, French DL, Dorman KS, Fidanza A, Campbell CA, Espin-Palazon R.   +13 more
europepmc   +1 more source

Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells

, 2011
Adult neural stem cells (NSCs) play important roles in\ud learning and memory and are negatively impacted by\ud neurological disease. It is known that biochemical and\ud genetic factors regulate self-renewal and differentiation,\ud and it has recently ...
Schaffer, David V., Elena M. de Juan-Pardo, Kumar, Sanjay, Keung, Albert J., Albert J. Keung, David V. Schaffer, Sanjay Kumar, de Juan-Pardo, Elena M.   +7 more
core   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

Expression of Concern: Novel Split-Luciferase-Based Genetically Encoded Biosensors for Noninvasive Visualization of Rho GTPases. [PDF]

PLoS One, 2023
PLOS ONE Editors.
europepmc   +1 more source