Results 171 to 180 of about 42,798 (278)

Profiling Ten RHO GTPases in Myeloid Malignancies Reveals Distinct Expression Patterns and Prognostic Associations. [PDF]

Cancer Med
de Almeida Rodrigues B, de Paiva LB, Ramalho MCC, Damasceno AF, Saad STO, Lazarini M.   +5 more
europepmc   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

An evolutionarily conserved salt bridge stabilizes the active site for GTP hydrolysis in Rho GTPases. [PDF]

J Biol Chem
Marcus K, Schwabe M, Knihtila R, Mattos C.   +3 more
europepmc   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro. [PDF]

PLoS One, 2023
Koch D, Kho AL, Fukuzawa A, Alexandrovich A, Vanaanen KJ, Beavil A, Pfuhl M, Rees M, Gautel M.   +8 more
europepmc   +1 more source

ZEB1 Modifies VE‐Cadherin Signaling in Lymphatic Endothelial Cells

Microcirculation, Volume 33, Issue 5, July 2026.
ABSTRACT Objective Zinc finger E‐box‐binding homeobox 1 (ZEB1) is a transcription factor primarily known for its regulatory roles in epithelial‐to‐mesenchymal transition (EMT) and cell fate determination. Recent studies suggest that endothelial ZEB1 signaling promotes blood vessel growth and reduces junctional integrity, although the underlying ...
Nada S. Ahmed, Joseph L. Horder, Charles T. Cresswell, Poppy E. Harris, Amy P. Lynch, Zarah B. Tabrizi, Kathryn R. Green, James H. Hallwood, Anton C. Smith, Michael A. Portelli, Alexander J. Fezovich, Christos Spanos, David S. Gardner, Alan McIntyre, Sarah J. Storr, Daniel G. Booth, David O. Bates, Andrew V. Benest   +17 more
wiley   +1 more source

Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: implications in disease and therapy. [PDF]

Cell Mol Life Sci, 2021
Raghavan A, Rao P, Neuzil J, Pountney DL, Nath S.   +4 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, Volume 20, Issue 6, Page 1420-1428, June 2026.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Somatic mutations in IRE1α regulate keratinocyte migration and survival by differentially activating Rho GTPases. [PDF]

J Cell Sci
Mogre S, Robinson L, Sethia K, Rimal B, Son J, Pacifico C, Santy L, Patterson A, Glick AB.   +8 more
europepmc   +1 more source

Rho family GTPases as key regulators for neuronal network formation

, 2002
Rho family GTPases act as transducers of signals from extracellular stimuli to the cytoskeleton and gene expression. Their actions are temporal and spatial determinants for cellular functions.
Hironori Katoh, Manabu Negishi
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