Results 181 to 190 of about 37,687 (240)
MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities
Cancer Science, Volume 117, Issue 8, Page 2050-2063, August 2026.Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah +3 more
wiley +1 more source
Cancer Science, Volume 117, Issue 8, Page 2208-2220, August 2026.CAFs could transfer EVs miR‐375 into endothelial cells with a low level of RASA1 and further promote EC angiogenesis. Plasma EVs miR‐375 have the potential values as a novel diagnostic and prognostic biomarker for HCC. ABSTRACT Cancer‐associated fibroblasts (CAFs) in the tumor microenvironment play an important role in cancer initiation and progression
Wei Qin +6 more
wiley +1 more source
Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer
Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo +6 more
wiley +1 more source
Application of Systems Genetics to Investigate Molecular Pathology of Early‐Onset Colorectal Cancer
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.Early‐onset colorectal cancer (EOCRC) presents a complex molecular landscape that requires integrated multi‐omics approaches. This article reviews current applications of systems genetics in EOCRC research and provides a step‐by‐step protocol for network‐based analyses featuring PIK3CA to demonstrate practical application for researchers of all levels.
Minjae J. Kim +3 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 8, August 2026.ABSTRACT Gastric cancer and gastroesophageal junction cancer, primarily adenocarcinoma, originate in the stomach's mucosa. Peritoneal metastasis is a common pattern in gastric cancer. The neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR), as systemic inflammation indicators, change before clinical symptoms, aiding early ...
Mahesh Wadhwa +5 more
wiley +1 more source
The emerging role of the Hippo signaling pathway in interorgan crosstalk
The FEBS Journal, Volume 293, Issue 16, Page 4769-4788, August 2026.Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song +2 more
wiley +1 more source
Mechanisms and Research Progress of Leech in Diabetic Ulcer Fibrosis
International Wound Journal, Volume 23, Issue 8, August 2026.ABSTRACT Delayed wound healing is a major complication of diabetes, with its core pathological process being pathological fibrosis driven by persistent inflammation, metabolic disorders and vascular dysfunction under hyperglycemia. This process involves pathological retention of inflammatory cells, abnormal expression of pro‐fibrotic factors, and ...
Yanchun Wang +3 more
wiley +1 more source
Plant G proteins: Versatile signaling hubs for synergistic improvement of agronomic traits
Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 3133-3152, August 2026.This review highlights the roles of G‐protein signaling in crop yield and quality, as well as abiotic and biotic stress responses. It also discusses the feasibility of breaking the trade‐off between plant growth and stress tolerance via dissecting G‐protein regulatory pathways, gene editing, mining natural elite variants, and AI‐assisted breeding ...
Haoran Li +7 more
wiley +1 more source
Root hair plasticity in cereals under abiotic stress
New Phytologist, Volume 251, Issue 4, Page 1684-1693, August 2026.An integrative perspective on how to study the regulation of root hair plasticity to increase the resilience of cereals to abiotic stress. Summary Abiotic stress is a constant threat to crop growth and yield in the context of climate change. Root systems that can best adapt their architecture to environmental challenges contribute to enhanced ...
Yaping Zhou, Frank Hochholdinger
wiley +1 more source