Results 201 to 210 of about 42,798 (278)

Rho GTPases Signaling in Zebrafish Development and Disease. [PDF]

Cells, 2020
Boueid MJ, Mikdache A, Lesport E, Degerny C, Tawk M.   +4 more
europepmc   +1 more source

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

SnapShot: Rho Family GTPases

Cell, 2007
Vega, F M, Ridley, A J
openaire   +3 more sources

Research Progress on Anti‐Inflammatory Adipokine SFRP5‐Mediated Lipid Metabolism and Its Potential Role in Neural Development

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Objective To systematically review the structural features of secreted frizzled‑related protein 5 (SFRP5) and its dual regulation of canonical/non‑canonical Wnt signaling, analyze its association with metabolic disorders, and specifically explore the role and mechanisms of the SFRP5–lipid metabolism axis in neural and optic nerve development ...
Qianfang Jia, Zihan Li, Tianyi Yang, Weihua Yang, Wei Chi   +4 more
wiley   +1 more source

Dysregulation of Rho GTPases in Human Cancers. [PDF]

Cancers (Basel), 2020
Jung H, Yoon SR, Lim J, Cho HJ, Lee HG.
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Tumour‐Derived Extracellular Vesicles Reprogramme Tumour‐Associated Macrophages Into Immunosuppressive Phenotype via NOD1 Signalling in Clear Cell Renal Cell Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Clear cell renal cell carcinoma (ccRCC)‐derived extracellular vesicles (EVs) play a pivotal role in myeloid cell differentiation toward immunosuppressive phenotypes, yet the underlying mechanisms remain poorly understood. Through integrated single‐nucleus RNA sequencing, EV proteomics, and phenotype validation, we identified NOD1, a pattern ...
Xiu‐wu Pan, Mu‐chen Li, Tian‐yue Yang, Yi‐fan Liu, Jia‐lin Zhou, Yi‐fan Tang, Hong‐feng Zheng, Jian‐gui Liu, Zi‐chang Liu, Wen‐jie Ma, Wen‐yan Li, Zi‐xuan Gong, Shun Zhang, Hang‐biao Zhang, Bing‐nan Lu, Yun‐tao Yao, Dong‐hao Lyu, Guan‐yu Zhu, Yuan‐bo Zong, Han‐lin Yao, Ai‐ping Zhang, Jin Zeng, Si‐tu Xiong, Ke‐qin Dong, Wang Zhou, Bin Fu, Xin‐gang Cui   +26 more
wiley   +1 more source

Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. [PDF]

Cancers (Basel), 2020
Streit L, Brunaud L, Vitale N, Ory S, Gasman S.   +4 more
europepmc   +1 more source

Stage‐Specific Molecular Cargo of Schwann Cell–Derived Extracellular Vesicles is Associated With Peripheral Nerve Repair

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Schwann cells (SCs) play a critical role in peripheral nerve regeneration, undergoing dynamic phenotype transitions from myelinating to repair stages following injury. While SC‐derived extracellular vesicles (SC‐EVs) have emerged as key mediators of intercellular communication during nerve repair, their stage‐specific molecular cargo and ...
Manju Sharma, Supasek Kongsomros, Maulee Sheth, Somchai Chutipongtanate, Leyla Esfandiari   +4 more
wiley   +1 more source

Pathogenic Mechanisms of V. vulnificus and Its Role in the Development of Sepsis

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Sorafenib attenuates urethral scar formation by inhibiting β‐catenin signaling in fibroblasts, which downregulates the SLC7A11/GPX4 antioxidant axis and triggers ferroptosis. This β‐catenin–ferroptosis coupling effectively suppresses fibrogenesis, highlighting sorafenib as a promising drug‐repurposing candidate for urethral stricture.
Zhongying Yu, Xianzhong Zhu, Shijie Tang, Shubo Yang, Jinyu Li, Lianzhong Luo, Yan Tan, Jun Yin   +7 more
wiley   +1 more source