Results 221 to 230 of about 72,889 (250)
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Current Protocols in Cell Biology, 2008
AbstractThe Rho GTPase family of signaling proteins controls a wide range of highly dynamic cellular processes. Activation of Rho GTPases can be investigated and quantified in cell extracts using so‐called pull‐down assays. Proteins that bind specifically to the activated form of the Rho GTPase are used to capture it onto a bead support.
Pellegrin, S, Mellor, H
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AbstractThe Rho GTPase family of signaling proteins controls a wide range of highly dynamic cellular processes. Activation of Rho GTPases can be investigated and quantified in cell extracts using so‐called pull‐down assays. Proteins that bind specifically to the activated form of the Rho GTPase are used to capture it onto a bead support.
Pellegrin, S, Mellor, H
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Nature Reviews Cancer, 2002
The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP. This is then exchanged for GTP and the cycle is repeated. The switching between these two states regulates a wide range of cellular processes.
Erik, Sahai, Christopher J, Marshall
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The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP. This is then exchanged for GTP and the cycle is repeated. The switching between these two states regulates a wide range of cellular processes.
Erik, Sahai, Christopher J, Marshall
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Rho GTPases in Hematopoietic Cells
Antioxidants & Redox Signaling, 2005The ubiquitous Rho GTPases are instrumental in the organization of the actin cytoskeleton, but also for the control of gene expression. Here we review the role of the major members of this family, i.e., RhoA, Rac1, Rac2, and Cdc42, and their intracellular signaling in hematopoietic cells.
Van Hennik, Paula B., Hordijk, Peter L.
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2005
The Rho (Ras-homologous) family of proteins constitutes a major branch of the Ras superfamily of small GTPases, and is evolutionarily conserved across several phyla. Thus far, 25 members have been identified, and these may be divided into 6 subfamilies based on amino acid sequence identity, structural motifs, and biological function.
Pinella, Buongiorno, Bharati, Bapat
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The Rho (Ras-homologous) family of proteins constitutes a major branch of the Ras superfamily of small GTPases, and is evolutionarily conserved across several phyla. Thus far, 25 members have been identified, and these may be divided into 6 subfamilies based on amino acid sequence identity, structural motifs, and biological function.
Pinella, Buongiorno, Bharati, Bapat
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European Journal of Cancer, 1999
Abstract The family members of small Rho-like GTPases, RhoA, Rac1 and Cdc42Hs, are regulators of diverse cellular signalling pathways, including cytoskeletal organisation, transcription and cell–cycle progression. Recent research has given insight into the complex regulation of cell–cell adhesion and migratory responses of epithelial cells.
E.E Sander, J.G Collard
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Abstract The family members of small Rho-like GTPases, RhoA, Rac1 and Cdc42Hs, are regulators of diverse cellular signalling pathways, including cytoskeletal organisation, transcription and cell–cycle progression. Recent research has given insight into the complex regulation of cell–cell adhesion and migratory responses of epithelial cells.
E.E Sander, J.G Collard
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Rho GTPases in hepatocellular carcinoma
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009Rho GTPases are major regulators of signal transduction pathways and play key roles in processes including actin dynamics, cell cycle progression, cell survival and gene expression, whose deregulation may lead to tumorigenesis. A growing number of in vitro and in vivo studies using tumor-derived cell lines, primary tumors and animal cancer models ...
Florence, Grise +2 more
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Bacterial Cytotoxins Target Rho GTPases
Naturwissenschaften, 1998Low molecular mass GTPases of the Rho family, which are involved in the regulation of the actin cytoskeleton and in various signal transduction processes, are the eukaryotic targets of bacterial protein toxins. The toxins covalently modify Rho proteins by ADP ribosylation, glucosylation, and deamidation, thereby inactivating and activating the GTPases.
Schmidt, Gudula, Aktories, Klaus
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RHO GTPASES: Biochemistry and Biology
Annual Review of Cell and Developmental Biology, 2005Approximately one percent of the human genome encodes proteins that either regulate or are regulated by direct interaction with members of the Rho family of small GTPases. Through a series of complex biochemical networks, these highly conserved molecular switches control some of the most fundamental processes of cell biology common to all eukaryotes ...
Aron B, Jaffe, Alan, Hall
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1999
It is becoming increasingly clear that the complex family of Rho-related GTPases and their associated regulators and targets are essential mediators of a variety of morphogenetic events required for normal development of multicellular organisms. It is worth noting that the results obtained thus far indicate that the Rho family proteins are largely ...
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It is becoming increasingly clear that the complex family of Rho-related GTPases and their associated regulators and targets are essential mediators of a variety of morphogenetic events required for normal development of multicellular organisms. It is worth noting that the results obtained thus far indicate that the Rho family proteins are largely ...
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Nature, 2002
Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells. They are known principally for their pivotal role in regulating the actin cytoskeleton, but their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just
Sandrine, Etienne-Manneville, Alan, Hall
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Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells. They are known principally for their pivotal role in regulating the actin cytoskeleton, but their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just
Sandrine, Etienne-Manneville, Alan, Hall
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