Results 71 to 80 of about 191,346 (272)
Advanced Functional Materials, EarlyView.The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar +6 more
wiley +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. [PDF]
PLoS ONE, 2013 BACKGROUND: Small GTPases (guanosine triphosphate, GTP) are involved in many critical cellular processes, including inflammation, proliferation, and migration.
Hongbing Xiao +3 more
doaj +1 more source
Rho GTPases as therapeutic targets in cancer (Review)
International Journal of Oncology, 2017 Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the ...
Georgina A. Cardama +4 more
semanticscholar +1 more source
At the Pointy End of Mechanobiology: AFM for Transient Biomechanical Analysis
Advanced Healthcare Materials, EarlyView.Stem cell mechanosensitivity governs lineage commitment through mechanotransduction, but capturing these transient changes in living cells remains challenging. Advanced atomic force microscopy enables high‐resolution analysis of mechanical properties, real‐time protein distribution, and gene expression, offering fresh insights into cell‐environment ...
Kaiwen Zhang +5 more
wiley +1 more source
The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis
Scientific Reports, 2017 Macrophage interactions with other cells, either locally or at distances, are imperative in both normal and pathological conditions. While soluble means of communication can transmit signals between different cells, it does not account for all long ...
Samer J Hanna +6 more
semanticscholar +1 more source
Rho GTPase-activating protein 10 (ARHGAP10/GRAF2) is a novel autoantibody target in patients with autoimmune encephalitis [PDF]
, 2022 Sven Jarius +5 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash +4 more
wiley +1 more source
Rho GTPases in ameloblast differentiation
Japanese Dental Science Review, 2016 During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial–mesenchymal interaction and a cell-autonomous gene network.
Keishi Otsu, Hidemitsu Harada
doaj +1 more source
The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases
Cells, 2016 The Rho GTPases regulate many cellular signaling cascades that modulate cell motility, migration, morphology and cell division. A large body of work has now delineated the biochemical cues and pathways, which stimulate the GTPases and their downstream ...
Jing-Ling Hoon, M. Tan, C. Koh
semanticscholar +1 more source