Results 81 to 90 of about 191,346 (272)

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source

Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord

Molecular Brain, 2009
Background Transplantation of neural stem/progenitor cells is a promising approach toward functional restoration of the damaged neural tissue, but the injured spinal cord has been shown to be an adverse environment for the survival, migration, and ...
Numano Fujiki, Inoue Akihiro, Enomoto Mitsuhiro, Shinomiya Kenichi, Okawa Atsushi, Okabe Shigeo   +5 more
doaj   +1 more source

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression

Advanced Science, EarlyView.
Twinfilin actin‐binding protein (TWF2) is upregulated in sunitinib‐resistant renal cell carcinoma (RCC) cells, where it interacts with YAP and protects YAP from degradation. Stabilized YAP translocates into the nucleus and activates transcription of target genes, promoting RCC progression and drug resistance.
Liangmin Fu, Wuyuan Liao, Youyan Tan, Hansen Lin, Kun Ye, Xinwei Zhou, Mingjie Lin, Kangbo Huang, Minyu Chen, Jietao Wei, Haoqian Feng, Yuhang Chen, Jinwei Chen, Bohong Guan, Shan Li, Zhengkun Zhang, Anze Yu, Zihao Feng, Lizhen Zhang, Guannan Shu, Jun Lu, Wei Chen, Yihui Pan, Jiefeng Yang, Junhang Luo, Li Luo   +25 more
wiley   +1 more source

Differential role for rapid proteostasis in Rho GTPase-mediated control of quiescent endothelial integrity [PDF]

, 2023
Fabienne Podieh, Roos Wensveen, Max C. Overboom, Lotte Abbas, Jisca Majolée, Peter L. Hordijk   +5 more
openalex   +1 more source

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

Advanced Science, EarlyView.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu, Qinqin Xie, Xiaodian Cai, Zhanming Zhong, Ran Wei, He Han, Shuang Liu, Zhenyang Zhang, Lingyao Xu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang, Zhe Zhang   +14 more
wiley   +1 more source

Multiscale Construction, Evaluation, and Application of Organoids

Advanced Science, EarlyView.
Organoids are pivotal models with transformative biomedical potential. A comprehensive multi‐scale perspective is presented, encompassing dual‐scale construction, four‐dimensional evaluation, triple‐point application, and an analysis of the current challenges faced by organoid technology, aiming to advance organoid research and its biomedical ...
Wanting Ma, Zhenglin Dong, Zhu'anzhen Zheng, Long Bai, Xingcai Zhang, Jiacan Su   +5 more
wiley   +1 more source

Rho GTPases: Anti- or Pro-neoplastic Targets?

Oncogene, 2016
Rho GTPases are critical signal transducers of multiple pathways. They have been proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven cancers.
Inuk Zandvakili, Yuan Lin, J. Morris, Y. Zheng   +3 more
semanticscholar   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells

Advanced Science, EarlyView.
Brief 10 min bursts of high frequency (10 MHz) vibrational mechanostimulation to stem cells are shown to activate their epigenetic machinery to condition their differentiation down an osteogenic lineage within just 3 days, which is much earlier than that with other forms of mechanostimuli, and without requiring any biochemical additives. Abstract Cells
Lizebona A. Ambattu, Blanca del Rosal, Carmelo Ferrai, Leslie Y. Yeo   +3 more
wiley   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source