Results 111 to 120 of about 104,378 (298)

Tuning Cellular Perception in Pluripotent Stem Cells through Topography, Stiffness, and Patterning

Advanced NanoBiomed Research, EarlyView.
Micro‐ and nanotopographical cues, substrate stiffness, and mechanical patterning synergistically direct pluripotent stem cell fate and function by tuning cellular perception at the biointerface. Pluripotent stem cells (PSCs), comprised of embryonic stem cells and induced PSCs, hold tremendous therapeutic potential.
Yuan Jiang, Jann Harberts, Yaping Chen, Richard J. Williams, Wei Duan, Rasika M. Samarasinghe, Nicolas H. Voelcker, Roey Elnathan   +7 more
wiley   +1 more source

Emodin-Induced Generation of Reactive Oxygen Species Inhibits RhoA Activation to Sensitize Gastric Carcinoma Cells to Anoikis

Neoplasia: An International Journal for Oncology Research, 2008
RhoA is a critical signaling molecule regulating a variety of cellular processes, such as cytoskeletal organization, adhesion, and apoptosis. It is recently considered responsive to reactive oxygen species (ROS). Nevertheless, how RhoA regulates anoikis,
Jun Cai, Xin Niu, Yuying Chen, Qingshen Hu, Guiying Shi, Huacheng Wu, Jian Wang, Jing Yi   +7 more
doaj   +1 more source

Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion [PDF]

, 2019
Kossay Zaoui, Zied Boudhraa, Paul Khalifé, Eurı́dice Carmona, Diane Provencher, Anne‐Marie Mes‐Masson   +5 more
openalex   +1 more source

RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes [PDF]

, 2021
Tobias Heib, Heike M. Hermanns, Georgi Manukjan, Maximilian Englert, Charly Kusch, Isabelle C. Becker, Annika Gerber, Lou Martha Wackerbarth, Philipp Burkard, Thomas Dandekar, Johannes Balkenhol, Daniel Jahn, Sarah Beck, Mara Meub, Sebastian Dütting, Christian Stigloher, Markus Sauer, Deya Cherpokova, Harald Schulze, Cord Brakebusch, Bernhard Nieswandt, Zoltán Nagy, Irina Pleines   +22 more
openalex   +1 more source

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

Acetylcholine-Induced Translocation of RhoA in Freshly Isolated Single Smooth Muscle Cells of Rat Bronchi

Journal of Pharmacological Sciences, 2004
By using immunofluorostaining and confocal laser microscopy, acetylcholine-induced translocation of RhoA was visualized in freshly isolated bronchial smooth muscle cells of the rat.
Yoshihiko Chiba, Tetsuro Uchida, Hiroyasu Sakai, Teruaki Oku, Saotomo Itoh, Tsutomu Tsuji, Miwa Misawa   +6 more
doaj   +1 more source

PKCα-mediated phosphorylation of the diacylglycerol kinase ζ MARCKS domain switches cell migration modes by regulating interactions with Rac1 and RhoA [PDF]

, 2021
Ryan Ard, Jean‐Christian Maillet, Elias Daher, Michael Phan, Radoslav Zinoviev, Robin J. Parks, Stephen Gee   +6 more
openalex   +1 more source

Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers. Gankyrin contributes to tumorigenesis by modulating key signaling pathways and engaging in oncogenic ...
Shuang Li, Yuky Lam, Aaron Muth, Zhe‐Sheng Chen, Shanzhi Wang   +4 more
wiley   +1 more source

Untangling the role of RhoA in the heart: protective effect and mechanism

Cell Death and Disease
RhoA (ras homolog family member A) is a small G-protein that transduces intracellular signaling to regulate a broad range of cellular functions such as cell growth, proliferation, migration, and survival.
Shigeki Miyamoto
doaj   +1 more source

Forsythoside A and Forsythoside B Contribute to Shuanghuanglian Injection-Induced Pseudoallergic Reactions through the RhoA/ROCK Signaling Pathway [PDF]

, 2019
Jiayin Han, Yu-Shi Zhang, Chen Pan, Zhong Xian, Chenling Pan, Yong Zhao, Chunying Li, Yan Yi, Lianmei Wang, Jingzhuo Tian, Suyan Liu, Dunfang Wang, Jing Meng, Aihua Liang   +13 more
openalex   +1 more source