Results 161 to 170 of about 123,069 (394)

Effect of Shear Stress on RhoA Activities and Cytoskeletal Organization in Chondrocytes [PDF]

, 2013
Indiana University-Purdue University Indianapolis (IUPUI)Mechanical force environment is a major factor that influences cellular homeostasis and remodeling.
Wan, Qiaoqiao
core   +1 more source

Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes

Journal of Neuroinflammation, 2017
BackgroundSphingosine 1-phosphate (S1P) signals through G protein-coupled receptors to elicit a wide range of cellular responses. In CNS injury and disease, the blood-brain barrier is compromised, causing leakage of S1P from blood into the brain. S1P can
Stephanie S. Dusaban, J. Chun, H. Rosen, N. Purcell, J. Brown   +4 more
semanticscholar   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia

Frontiers in Molecular Neuroscience, 2012
RhoA, a member of Rho family small GTPases, has been shown to play important roles in axon guidance. However, it remains unknown whether RhoA is actually required for any axon guidance events in vivo in the mammalian nervous system.
Jennifer R Leslie, Fumiyasu eImai, Xuan eZhou, Richard A Lang, Yi eZheng, Yutaka eYoshida   +5 more
doaj   +1 more source

Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage

bioRxiv, 2016
Cytokinetic cleavage furrows assemble during anaphase at a site that is dictated by the position of the spindle. The GTPase RhoA promotes contractile ring assembly and furrow ingression during cytokinesis.
Elizabeth Wagner, M. Glotzer
semanticscholar   +1 more source

Cellpose+, a Morphological Analysis Tool for Feature Extraction of Stained Cell Images

Advanced Intelligent Discovery, EarlyView.
We introduce Cellpose plus, a morphological and geometrical analysis tool for feature extraction of stained cell images built over Cellpose, a state‐of‐the‐art cell segmentation framework. We also introduce a dataset of DAPI and FITC stained cells to which our new method is applied.
Israel A. Huaman, Fares D. E. Ghorabe, Sofya S. Chumakova, Alexandra A. Pisarenko, Alexey E. Dudaev, Tatiana G. Volova, Galina A. Ryltseva, Sviatlana A. Ulasevich, Ekaterina I. Shishatskaya, Ekaterina V. Skorb, Pavel S. Zun   +10 more
wiley   +1 more source

Untangling the role of RhoA in the heart: protective effect and mechanism

Cell Death and Disease
RhoA (ras homolog family member A) is a small G-protein that transduces intracellular signaling to regulate a broad range of cellular functions such as cell growth, proliferation, migration, and survival.
Shigeki Miyamoto
doaj   +1 more source

cGMP signaling inhibits platelet shape change through regulation of the RhoA‐Rho Kinase‐MLC phosphatase signaling pathway [PDF]

, 2017
Ahmed Aburima, K. Walladbegi, Jonathan D. Wake, Khalid M. Naseem   +3 more
openalex   +1 more source

Excitable RhoA dynamics drive pulsed contractions in the early C. elegans embryo

bioRxiv, 2016
Pulsed actomyosin contractility underlies diverse modes of tissue morphogenesis, but the underlying mechanisms remain poorly understood. Here, we combine quantitative imaging with genetic perturbations to identify a core mechanism for pulsed ...
Jonathan B. Michaux, François B. Robin, William M. McFadden, E. Munro   +3 more
semanticscholar   +1 more source

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen, Wei Liu, Dan Zhou, Shuhua Liu, Yalun Guan, Zongyu Miao, Lei Cai, Xuejiao Li, Yunfeng Li, Zhongqiang Huang, Yi Jin, Ge Li, Yu Zhang   +12 more
wiley   +1 more source