Results 91 to 100 of about 3,677,140 (187)
, 2023 This research investigated the role of RhoA, a small G-protein, in cardioprotection against ischemic stress and showed that RhoA regulates the PINK1 stability to stimulate mitophagy, providing a cell survival advantage.Mitophagy removes dysfunctional ...
Shigeki Miyamoto (17398333)
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Advanced Science, Volume 13, Issue 40, 17 July 2026.CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng +16 more
wiley +1 more source
From Cytoskeletal Remodeling to Oocyte Quality: The Emerging Role of Mechanics
Advanced Science, Volume 13, Issue 41, 22 July 2026.Mechanical properties of the oocyte are increasingly recognized as critical determinants of meiotic success and developmental potential. How actomyosin remodeling controls oocyte mechanics, how these properties are altered in pathological conditions, and how they could serve as markers in reproductive medicine are examined.
Anastasia Shihabi +3 more
wiley +1 more source
Review of cellular and molecular pathways linking thrombosis and innate immune system during sepsis
Journal of Research in Medical Sciences, 2010 Cellular and molecular pathways link thrombosis and innate immune system during sepsis. Extrinsic pathway activation of protease thrombin through FVIIa and tissue factor (TF) in sepsis help activate its endothelial cell (EC) membrane Protease Activated ...
Filip A Konecny
doaj
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility [PDF]
, 2006 Background The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9.
Martin Ruthardt +14 more
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Cloning and characterisation of genes determining pod morphology in pea [PDF]
, 1994 Genes expressed in developing pea pods were isolated as cDNAs by differential screening techniques. The cDNAs were characterised by DNA sequencing and expression studies were used to investigate the role of isolated cDNAs in pod development.
Drew, J.E, Drew, Janice Elizabeth
core
Structural intermediates in the assembly of taxoid-induced microtubules and GDP-tubulin double rings: time-resolved X-ray scattering [PDF]
, 1996 We have studied the self-association reactions of purified GDP-liganded tubulin into double rings and taxoid-induced microtubules, employing synchrotron time-resolved x-ray solution scattering.
Diaz, J.F. +6 more
core +1 more source
New Angle of View on the Role of Rho/Rho Kinase Pathway in Human Diseases
Iranian Journal of Allergy, Asthma and Immunology, 2014 Rho-kinase is an effector molecule of RhoA, a monomeric GTP-binding protein, and causes Ca2+ sensitization through inactivation of myosin phosphatase.
Wei Luo +4 more
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