Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors. [PDF]
, 1994 This study examines the regulation of cGMP by illumination and by calcium during signal transduction in vertebrate retinal photoreceptor cells. We employed an electropermeabilized rod outer segment (EP-ROS) preparation which permits perfusion of low ...
Coccia, V J, Cote, Rick H.
core +2 more sources
PLoS Genetics, 2021 Color vision in Drosophila melanogaster is based on the expression of five different color-sensing Rhodopsin proteins in distinct subtypes of photoreceptor neurons.
Clara Poupault +8 more
doaj +1 more source
Acid‐ and Nucleophile‐Gated Photoisomerization of Phosphaindirubin
Angewandte Chemie, EarlyView.Triply gated isomerization: In polar solvents, a phosphorus‐containing indirubin photoswitch undergoes visible‐light‐driven Z→E isomerization only when protonated, and reverts thermally via nucleophile‐catalyzed back‐isomerization. This three‐way control by light, acid, and nucleophile enables reversible photoisomerization.
Jacob Jan van der Wal +8 more
wiley +2 more sources
Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish [PDF]
, 2017 The authors would like to thank the Royal Society of London, the National Eye Research Centre, the Visual Research Trust, Fight for Sight, the W.H. Ross Foundation, the Rosetrees Trust, and the Glasgow Children’s Hospital Charity for supporting this work.
A Eblimit +54 more
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Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation.
PLoS ONE, 2011 The P23H mutation in the rhodopsin gene causes rhodopsin misfolding, altered trafficking and formation of insoluble aggregates leading to photoreceptor degeneration and autosomal dominant retinitis pigmentosa (RP).
Vidyullatha Vasireddy +8 more
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Coexpression of spectrally distinct rhodopsins in Aedes aegypti R7 photoreceptors. [PDF]
PLoS ONE, 2011 The retina of the mosquito Aedes aegypti can be divided into four regions based on the non-overlapping expression of a UV sensitive Aaop8 rhodopsin and a long wavelength sensitive Aaop2 type rhodopsin in the R7 photoreceptors.
Xiaobang Hu +4 more
doaj +1 more source
Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis [PDF]
, 2012 Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision.
A Poltorak +89 more
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Disease Models & Mechanisms, 2022 The P23H mutation in rhodopsin (Rho), the rod visual pigment, is the most common allele associated with autosomal-dominant retinitis pigmentosa (adRP). The fate of misfolded mutant Rho in rod photoreceptors has yet to be elucidated.
Michael A. Robichaux +6 more
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Lipid−Rhodopsin Hydrophobic Mismatch Alters Rhodopsin Helical Content [PDF]
Journal of the American Chemical Society, 2008 The ability of photoactivated rhodopsin to achieve the enzymatically active metarhodopsin II conformation is exquisitely sensitive to bilayer hydrophobic thickness. The sensitivity of rhodopsin to the lipid matrix has been explained by the hydrophobic matching theory, which predicts that lipid bilayers adjust elastically to the hydrophobic length of ...
Olivier, Soubias +3 more
openaire +2 more sources
Evolutionary history of teleost intron-containing and intron-less rhodopsin genes
Scientific Reports, 2019 Recent progress in whole genome sequencing has revealed that animals have various kinds of opsin genes for photoreception. Among them, most opsin genes have introns in their coding regions.
Chihiro Fujiyabu +5 more
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