Results 1 to 10 of about 914 (105)

Rhoifolin Improves Glycometabolic Control in Streptozotocin-Induced Diabetic Rats by Up-Regulating the Expression of Insulin Signaling Proteins and Down-Regulating the MAPK/JNK Pathway [PDF]

Pharmaceuticals
Background and Aim: Rhoifolin is a bioactive flavonoid that possesses strong antioxidant and anti-inflammatory activities. The current investigation aimed to examine the anti-diabetic potential of rhoifolin in streptozotocin-induced diabetic rats.
Maryam Ehsan, Sibtain Ahmed, Wafa Majeed, Asra Iftikhar, Maryam Iftikhar, Mateen Abbas, Tahir Mehmood   +6 more
doaj   +2 more sources

Rhoifolin: A promising flavonoid with potent cytotoxic and anticancer properties [PDF]

EXCLI Journal : Experimental and Clinical Sciences
Rhoifolin is a flavonoid found in various plant species, especially within the Rutaceae family, and is considered a dietary component due to its presence in edible plants. Its bioactive properties, such as cytotoxic and anticancer activities, have gained
Ceyda Sibel Kılıç, Mehmet Murat Kışla, Gülin Amasya, Ceyda Tuğba Şengel-Türk, Zeynep Ateş Alagöz, Ayşe Mine Gençler Özkan, İlker Ateş, Safa Gümüşok, Jesús Herrera-Bravo, Javad Sharifi-Rad, Daniela Calina   +10 more
doaj   +2 more sources

Therapeutic efficacy of rhoifolin in type 2 diabetes mellitus: Effects on metabolic parameters, hepatic function, and oxidative stress: a dose-dependent study [PDF]

Frontiers in Pharmacology
Background/objectivesDiabetes is one of the most prevalent chronic disorders globally and is linked to obesity. Research has shown that rhoifolin (ROF) can effectively treat metabolic illnesses.
Sndos Z. Fattiny, Manal Abdulaziz Binobead, Abu ElGasim A. Yagoub, Ghedeir M. Alshammari, Ali Saleh, Mohammed Abdo Yahya   +5 more
doaj   +2 more sources

Fat Browning Effects of Catalpol and Rhoifolin from Rehmannia glutinosa (Gaertn.) and Lonicera japonica (Thunb.) in 3T3-L1 Adipocytes via the β3-AR Signaling Pathway [PDF]

Pharmaceuticals
Background/Objectives: Promoting white adipose tissue (WAT) browning into thermogenic beige adipocytes is a promising anti-obesity strategy. Yanggyeoksanhwa-tang (YST) has been used traditionally to alleviate obesity-related conditions.
Seung Min Choi, Sung Ho Lim, Ho Seon Lee, Gayoung Choi, Myeong Ji Kim, Hyunwoo Kim, Chang-Ik Choi   +6 more
doaj   +2 more sources

Rhoifolin from Plumula Nelumbinis exhibits anti-cancer effects in pancreatic cancer via AKT/JNK signaling pathways

Scientific Reports, 2022
This study aimed to evaluate the anti-pancreatic cancer effects of flavonoids in Plumula Nelumbinis. High-performance liquid chromatography/quadrupole time-of-flight mass spectrometry showed that apiin, rhoifolin, and vitexin were three principal ...
Baodong Zheng, Yixin Zheng, Ningning Zhang   +2 more
exaly   +2 more sources

Rhoifolin Suppresses Cell Proliferation and Induces Apoptosis in Hepatocellular Carcinoma Cells In Vitro and In Vivo [PDF]

Pharmaceuticals
Background: Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor, ranking fifth in terms of fatality with poor prognosis and a low survival rate.
Ruolan Chen, Zufa Sabeel, Lu Ying, Youfeng Liang, Rui Guo, Mingxuan Hao, Xiaoyang Chen, Wenjing Zhang, Jian Dong, Yan Liu, Changyuan Yu, Zhao Yang   +11 more
doaj   +2 more sources

Evaluating the inhibitory efficacy of Oxalis phytocompounds on monoamine oxidase B: An integrated approach targeting age related neurodegenerative diseases through molecular docking and dynamics simulations. [PDF]

PLoS ONE
Monoamine oxidase B (MAO-B) serves as a critical target in the management of neurodegenerative diseases (NDDs) such as Alzheimer's and Parkinson's due to its role in regulating oxidative stress and dopamine metabolism.
Ram Lal Swagat Shrestha, Shiva M C, Ashika Tamang, Manila Poudel, Nirmal Parajuli, Aakar Shrestha, Timila Shrestha, Samjhana Bharati, Binita Maharjan, Bishnu P Marasini, Jhashanath Adhikari Subin   +10 more
doaj   +2 more sources

Network pharmacology, bioinformatics and in vitro/in vivo validation elucidate the anti-lung cancer activities and potential targets of Rhoifolin [PDF]

Frontiers in Pharmacology
BackgroundRhoifolin (ROF), a naturally occurring flavonoid, exhibits broad bioactivities, but its therapeutic potential and underlying mechanisms in lung cancer remain largely unknown.
Jing Qian, Wei Cheng, Shuangyan Li, Li Deng, Di Gao, Xue Zhang, Yunhui Zhang   +6 more
doaj   +2 more sources

Computational screening combined with well-tempered metadynamics simulations identifies potential TMPRSS2 inhibitors [PDF]

Scientific Reports
Type-II transmembrane serine proteases are effective pharmacological targets for host defence against viral entry and in certain cancer cell progressions.
C. S. Sharanya, D. Sasikala Wilbee, Shijulal Nelson Sathi, Kathiresan Natarajan   +3 more
doaj   +2 more sources

Determination of bioactive and anti-inflammatory molecules of Thymbra spicata L. from Mardin by GC–MS and LC–Orbitrap HRMS: a DFT, molecular docking, ADMET, biological target and activity study [PDF]

BMC Complementary Medicine and Therapies
Objectives In this study, phenolic compounds (PC), volatile compounds (VC), antioxidant, anti-inflammatory, and antimicrobial properties of the Thymbra spicata L. plant grown in the Mardin Yeşilli region were investigated.
Velid Unsal, Leyla Ercan, Cemile Gunbegi Calıskan   +2 more
doaj   +2 more sources