Results 1 to 10 of about 291 (141)

Rhoifolin Suppresses Cell Proliferation and Induces Apoptosis in Hepatocellular Carcinoma Cells In Vitro and In Vivo

Pharmaceuticals
Background: Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor, ranking fifth in terms of fatality with poor prognosis and a low survival rate.
Zhao Yang
exaly   +6 more sources

Rhoifolin Ameliorates Osteoarthritis via Regulating Autophagy [PDF]

Frontiers in Pharmacology, 2021
Osteoarthritis (OA) is a common age-related joint disease. Its development has been generally thought to be associated with inflammation and autophagy.
Yifan Xiao, Hua Wu, Jiyuan Yan
exaly   +5 more sources

Ameliorative Effects of Rhoifolin in Scopolamine-Induced Amnesic Zebrafish (Danio rerio) Model [PDF]

Antioxidants, 2020
Rhoifolin (Rho) exerts many biological activities such as anticancer, antidiabetic, hepatoprotective, antirheumatic, antibacterial, and antiviral properties. The neuroprotective action of this compound has not been studied.
Ion Brinza, Ahmed M. Abd-Alkhalek, Mohamed A. El-Raey, Razvan Stefan Boiangiu, Omayma A. Eldahshan, Lucian Hritcu   +5 more
doaj   +4 more sources

Rhoifolin Alleviates Alcoholic Liver Disease In Vivo and In Vitro via Inhibition of the TLR4/NF-κB Signaling Pathway

Frontiers in Pharmacology, 2022
Background: Alcoholic liver disease (ALD) is a common chronic liver disorder worldwide, which is detrimental to human health. A preliminary study showed that the total flavonoids within Citrus grandis “Tomentosa” exerted a remarkable effect on the ...
Fengxia Xiao
exaly   +5 more sources

Discovery of New Inhibitors of eEF2K from Traditional Chinese Medicine Based on In Silico Screening and In Vitro Experimental Validation

Molecules, 2022
Eukaryotic elongation factor 2 kinase (eEF2K) is a highly conserved α kinase and is increasingly considered as an attractive therapeutic target for cancer as well as other diseases.
Qinghua Fu, Xiaomei Liu, Yan Li, Peng Wang, Tian Wu, Haihan Xiao, Yameng Zhao, Qichao Liao, Ziyi Song   +8 more
doaj   +2 more sources

Rhoifolin from Plumula Nelumbinis exhibits anti-cancer effects in pancreatic cancer via AKT/JNK signaling pathways

Scientific Reports, 2022
This study aimed to evaluate the anti-pancreatic cancer effects of flavonoids in Plumula Nelumbinis. High-performance liquid chromatography/quadrupole time-of-flight mass spectrometry showed that apiin, rhoifolin, and vitexin were three principal ...
Bingxin Zheng, Yixin Zheng, Ningning Zhang, Yi Zhang, Baodong Zheng   +4 more
doaj   +3 more sources

Therapeutic efficacy of rhoifolin in type 2 diabetes mellitus: Effects on metabolic parameters, hepatic function, and oxidative stress: a dose-dependent study

Frontiers in Pharmacology
Background/objectivesDiabetes is one of the most prevalent chronic disorders globally and is linked to obesity. Research has shown that rhoifolin (ROF) can effectively treat metabolic illnesses.
Manal Binobead, Mohammed Abdo Yahya, Abu Elgasim Yagoub   +2 more
exaly   +3 more sources

Rhoifolin regulates oxidative stress and proinflammatory cytokine levels in Freund’s adjuvant-induced rheumatoid arthritis via inhibition of NF-κB [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Rheumatoid arthritis (RA) is an autoimmune disease of knee joints involving pain and inflammation. Rhoifolin is a plant flavonoid known to have antioxidant and anti-inflammatory properties.
Shanqin Peng, Congqi Hu, Xi Liu, Lei Lei, Guodong He, Chenming Xiong, Wenqian Wu   +6 more
doaj   +1 more source

Flavone glycosides from Uraria crinita

Vietnam Journal of Science, Technology and Engineering, 2021
Four flavone glycosides including apigenin 7-O-β-glucoside (1), chrysoeriol 7-O-β-glucoside (2), rhoifolin (3), and 3′-methoxyapiin (4) were isolated from the n-butanol extract of the whole plant Uraria crinita collected in the phu Tho province, Vietnam.
Tran Duc Dai, Dao Duc Thien, Nguyen Thanh Tam   +2 more
doaj   +1 more source

Metabolic Profiling and Transcriptome Analysis Reveal the Key Role of Flavonoids in Internode Coloration of Phyllostachys violascens cv. Viridisulcata

Frontiers in Plant Science, 2022
Bamboo, being an ornamental plant, has myriad aesthetic and economic significance. Particularly, Phyllostachys violascens cv. Viridisulcata contains an internode color phenotype in variation in green and yellow color between the sulcus and culm ...
Han-tian Wei, Dan Hou, Muhammad Furqan Ashraf, Hai-Wen Lu, Juan Zhuo, Jia-long Pei, Qi-xia Qian   +6 more
doaj   +1 more source