Results 1 to 10 of about 1,365 (165)

Rhoifolin from Plumula Nelumbinis exhibits anti-cancer effects in pancreatic cancer via AKT/JNK signaling pathways [PDF]

Scientific Reports, 2022
This study aimed to evaluate the anti-pancreatic cancer effects of flavonoids in Plumula Nelumbinis. High-performance liquid chromatography/quadrupole time-of-flight mass spectrometry showed that apiin, rhoifolin, and vitexin were three principal ...
Yi Zhang, Baodong Zheng
exaly   +5 more sources

Rhoifolin: A promising flavonoid with potent cytotoxic and anticancer properties [PDF]

EXCLI Journal : Experimental and Clinical Sciences
Rhoifolin is a flavonoid found in various plant species, especially within the Rutaceae family, and is considered a dietary component due to its presence in edible plants. Its bioactive properties, such as cytotoxic and anticancer activities, have gained
Ceyda Sibel Kılıç, Mehmet Murat Kışla, Gülin Amasya, Ceyda Tuğba Şengel-Türk, Zeynep Ateş Alagöz, Ayşe Mine Gençler Özkan, İlker Ateş, Safa Gümüşok, Jesús Herrera-Bravo, Javad Sharifi-Rad, Daniela Calina   +10 more
doaj   +4 more sources

Rhoifolin Suppresses Cell Proliferation and Induces Apoptosis in Hepatocellular Carcinoma Cells In Vitro and In Vivo [PDF]

Pharmaceuticals
Background: Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor, ranking fifth in terms of fatality with poor prognosis and a low survival rate.
Ruolan Chen, Zufa Sabeel, Lu Ying, Youfeng Liang, Rui Guo, Mingxuan Hao, Xiaoyang Chen, Wenjing Zhang, Jian Dong, Yan Liu, Changyuan Yu, Zhao Yang   +11 more
doaj   +3 more sources

Rhoifolin Alleviates Alcoholic Liver Disease In Vivo and In Vitro via Inhibition of the TLR4/NF-κB Signaling Pathway

Frontiers in Pharmacology, 2022
Background: Alcoholic liver disease (ALD) is a common chronic liver disorder worldwide, which is detrimental to human health. A preliminary study showed that the total flavonoids within Citrus grandis “Tomentosa” exerted a remarkable effect on the ...
Fengxia Xiao
exaly   +5 more sources

Rhoifolin Improves Glycometabolic Control in Streptozotocin-Induced Diabetic Rats by Up-Regulating the Expression of Insulin Signaling Proteins and Down-Regulating the MAPK/JNK Pathway [PDF]

Pharmaceuticals
Background and Aim: Rhoifolin is a bioactive flavonoid that possesses strong antioxidant and anti-inflammatory activities. The current investigation aimed to examine the anti-diabetic potential of rhoifolin in streptozotocin-induced diabetic rats.
Maryam Ehsan, Sibtain Ahmed, Wafa Majeed, Asra Iftikhar, Maryam Iftikhar, Mateen Abbas, Tahir Mehmood   +6 more
doaj   +2 more sources

Therapeutic efficacy of rhoifolin in type 2 diabetes mellitus: Effects on metabolic parameters, hepatic function, and oxidative stress: a dose-dependent study [PDF]

Frontiers in Pharmacology
Background/objectivesDiabetes is one of the most prevalent chronic disorders globally and is linked to obesity. Research has shown that rhoifolin (ROF) can effectively treat metabolic illnesses.
Sndos Z. Fattiny, Manal Abdulaziz Binobead, Abu ElGasim A. Yagoub, Ghedeir M. Alshammari, Ali Saleh, Mohammed Abdo Yahya   +5 more
doaj   +2 more sources

Discovery of New Inhibitors of eEF2K from Traditional Chinese Medicine Based on In Silico Screening and In Vitro Experimental Validation [PDF]

Molecules, 2022
Eukaryotic elongation factor 2 kinase (eEF2K) is a highly conserved α kinase and is increasingly considered as an attractive therapeutic target for cancer as well as other diseases.
Qinghua Fu, Xiaomei Liu, Yan Li, Peng Wang, Tian Wu, Haihan Xiao, Yameng Zhao, Qichao Liao, Ziyi Song   +8 more
doaj   +2 more sources

Evaluating the inhibitory efficacy of Oxalis phytocompounds on monoamine oxidase B: An integrated approach targeting age related neurodegenerative diseases through molecular docking and dynamics simulations. [PDF]

PLoS ONE
Monoamine oxidase B (MAO-B) serves as a critical target in the management of neurodegenerative diseases (NDDs) such as Alzheimer's and Parkinson's due to its role in regulating oxidative stress and dopamine metabolism.
Ram Lal Swagat Shrestha, Shiva M C, Ashika Tamang, Manila Poudel, Nirmal Parajuli, Aakar Shrestha, Timila Shrestha, Samjhana Bharati, Binita Maharjan, Bishnu P Marasini, Jhashanath Adhikari Subin   +10 more
doaj   +2 more sources

Network pharmacology, bioinformatics and in vitro/in vivo validation elucidate the anti-lung cancer activities and potential targets of Rhoifolin [PDF]

Frontiers in Pharmacology
BackgroundRhoifolin (ROF), a naturally occurring flavonoid, exhibits broad bioactivities, but its therapeutic potential and underlying mechanisms in lung cancer remain largely unknown.
Jing Qian, Wei Cheng, Shuangyan Li, Li Deng, Di Gao, Xue Zhang, Yunhui Zhang   +6 more
doaj   +2 more sources

Effect and mechanism of longkui yinxiao soup in treating psoriasis in mice [PDF]

Frontiers in Pharmacology, 2023
Objective: Longkui Yinxiao Soup is a traditional Chinese medicine formula used to treat psoriasis for decades. Although Longkui Yinxiao Soup showed promising efficacy in clinical practice, the regulatory mechanisms of Longkui Yinxiao Soup remain elusive.
Congcong Zhu, Congcong Zhu, Ya Chen, Ya Chen, Zongguang Tai, Zongguang Tai, Huijun Pan, Huijun Pan, Min Shen, Min Shen, Zhongjian Chen, Zhongjian Chen, Quangang Zhu, Quangang Zhu   +13 more
doaj   +2 more sources