Results 41 to 50 of about 44,845 (209)

ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection. [PDF]

PLoS ONE, 2015
BACKGROUND & AIM:Whether inosine triphosphatase (ITPA) gene polymorphisms predict anemia during interferon-free therapy in chronic hepatitis C virus (HCV)-infected patients is unknown.
Tarik Asselah, Stefan Zeuzem, Vicente Soriano, Jean-Pierre Bronowicki, Ansgar W Lohse, Beat Müllhaupt, Marcus Schuchmann, Marc Bourlière, Maria Buti, Stuart K Roberts, Edward J Gane, Jerry O Stern, Florian Voss, Patrick Baum, John-Paul Gallivan, Wulf O Böcher, Federico J Mensa   +16 more
doaj   +1 more source

Crystallization Selectivity of Ribavirin Solution and Amorphous Phase

Molecules, 2023
Crystallization selectivity is an important principle in polymorph control. Ribavirin Form I, Form II, DMSO solvate, and amorphous ribavirin are prepared, and the short-range order similarities between these solid forms and ribavirin aqueous solution and
Fuying Li, Shiying Chen, Haoxin Hu, Chengfeng Liang, Shiyu Sun, Can Jin, Fenghua Chen   +6 more
doaj   +1 more source

Bee products as alternatives in the treatment of viral infections

Journal of the Science of Food and Agriculture, Volume 106, Issue 1, Page 33-54, 15 January 2026.
Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba, Łukasz Marek, Jerzy Stojko, Anna Rzepecka‐Stojko   +3 more
wiley   +1 more source

The Neurological Effects of Ribavirin in Crimean-congo Hemorrhagic Fever Symptoms: A Systematic Review [PDF]

Caspian Journal of Neurological Sciences
Background: Ribavirin is widely used in treating viral infections like Crimean-Congo hemorrhagic fever (CCHF), which is a severe disease with high morbidity and mortality.
Hossein Hatami, Mohammad Javad Nasiri, Kimia Eyvani, Mobina Fatthy   +3 more
doaj  

Association of IL28B Polymorphisms With Hepatitis C Susceptibility in Southern Iran's β‐Thalassemia Population: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Thalassemia is a hereditary hematological condition which interferes with the production of hemoglobin (Hb). Patients with thalassemia require regular blood transfusion, which makes them highly susceptible to pathogens, and especially viral pathogens.
Fatemeh Askari, Masoud Kargar, Zeinab Deris Zayeri, Mohammad Ali Jalalifar, Bijan Keikhaei, Gholam Abbas Kaydani   +5 more
wiley   +1 more source

Ribavirin exerts differential effects on functions of Cd4+ Th1, Th2, and regulatory T cell clones in hepatitis C. [PDF]

PLoS ONE, 2012
Ribavirin improves outcomes of therapy in chronic hepatitis C but its mode of action has still remained unclear. Since ribavirin has been proposed to modulate the host's T cell responses, we studied its direct effects on CD4(+) T cell clones with diverse
Bettina Langhans, Hans Dieter Nischalke, Simone Arndt, Ingrid Braunschweiger, Jacob Nattermann, Tilman Sauerbruch, Ulrich Spengler   +6 more
doaj   +1 more source

Graded Calorie Restriction Causes Graded Slowing of Epigenetic Ageing in Mice

Aging Cell, Volume 25, Issue 1, January 2026.
Graded calorie restriction in male mice modified epigenetic signatures of the liver and slowed ageing rate in a graded manner. ABSTRACT DNA methylation variation is associated with chronological ageing. Calorie restriction (CR) prolongs lifespan and healthspan in many species.
Timothy P. Moulds, Sharon E. Mitchell, Xiaojing Yang, Wei Guo, Emily Chen, Peter D. Adams, John R. Speakman   +6 more
wiley   +1 more source

Ribavirin Induces Polyamine Depletion via Nucleotide Depletion to Limit Virus Replication

Cell Reports, 2019
Summary: Common antivirals include nucleoside or nucleotide analogs with base prodrugs. The antiviral ribavirin, a US Food and Drug Administration (FDA)-approved nucleoside antimetabolite, halts guanine production, mutagenizes viral genomes, and ...
Patrick M. Tate, Vincent Mastrodomenico, Bryan C. Mounce   +2 more
doaj   +1 more source

The Differential Effects of Immunosuppressants on Hepatitis E Virus Replication and the Triggered Inflammatory Responses in Macrophages

Journal of Viral Hepatitis, Volume 33, Issue 1, January 2026.
ABSTRACT Organ transplant recipients are at high risk of developing chronic infection when exposed to hepatitis E virus (HEV), which can rapidly progress to liver fibrosis and cirrhosis. Macrophages play a key role in the response to the infection and disease progression.
Jiahua Zhou, Kuan Liu, Patrick P. C. Boor, Qiuwei Pan, Ibrahim Ayada   +4 more
wiley   +1 more source

Free‐Form Microfluidic Microneedle Array Patches

Advanced Functional Materials, Volume 35, Issue 52, December 23, 2025.
Microfluidic microneedle array patches (MAPs) integrate hollow microneedles with embedded microfluidic channels, fabricated using high‐resolution 3D printing, to enable controlled transdermal delivery of liquid, mixed, or reconstituted therapeutics.
Ian A. Coates, Madison M. Driskill, Netra U. Rajesh, Gabriel Lipkowitz, Dan Ilyn, Yue Xu, Maria T. Dulay, Gunilla B. Jacobson, John R. Tumbleston, Jillian L. Perry, Shaomin Tian, Joseph M. DeSimone   +11 more
wiley   +1 more source