Results 81 to 90 of about 620,035 (172)

Riboflavin Free Conditions Decrease Mitochondrial Flux in COS-7 and HCT116 Bmut Cells.

, 2023
Riboflavin deficiency and/or mutation of riboflavin transporters are the major contributors towards rare pediatric neurodegenerative disorders. Riboflavin Transporter Deficiency, RTD, particularly affects motor neurons leading to common symptoms ...
Sterling, Felicity, Wu, Christina
core   +1 more source

Gut Microbiota of Gray Snub‐Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis

Integrative Zoology, EarlyView.
Based on metagenome‐assembled genomes (MAGs), the gut microbiota of the gray snub‐nosed monkeys recovered 1229 non‐redundant MAGs. The gut microbiota showed an enhanced capacity to produce energy substrates with increased conversion activity of these substrates during winter.
Yue Sun, Mingyi Zhang, Xiaochen Wang, Xiaolong Huang, Yanze Yu, Huijuan Pan, Haibo Li, Lei Shi, Wei Yang, Chen Zhang, Bo Ding, Xun Liu, Jianfeng Li, Changjiang Qian, Boxing Cheng, Chao Zhang, Jingcheng Ran, Ming Li   +17 more
wiley   +1 more source

Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women [PDF]

, 2010
Pregnancy is a condition exhibiting increased susceptibility to oxidative stress, and Fe plays a central role in generating harmful oxygen species. The objective of the present study is to investigate the changes in haematological status, oxidative ...
Frans J. Kok, Chen Jiang, D., Zhi Zhang, Feng, Kok, F.J., Ai Guo Ma, Fang Yang, Yong Ye Sun, Xiu Xia Han, Xia Han, Xiu, Feng Zhi Zhang, Dian Chen Jiang, Ye Sun, Yong, Schouten, E.G., Aiguo, M., Yang, Fang, Evert G. Schouten   +15 more
core   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Guanidinoacetic Acid Improves Growth Performance and Gut Health of Broilers Fed Metabolizable Energy‐Reduced Diets

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study was conducted to evaluate the effects of guanidinoacetic acid (GAA) supplementation to diets with different energy levels on growth performance, carcass traits, and gut health status in broiler chickens. A total of 9500 1‐day‐old Ross 308 broilers (equal numbers of males and females) were allocated to 1 of 5 dietary treatments (10 ...
Necmettin Ceylan, Ali Anıl Çenesiz, İsmail Yavaş, Sait Koca, Vivienne Inhuber   +4 more
wiley   +1 more source

Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn, Fabian B. Haas, Benjamin G. Chavez, Bernd H. Dreyer, Erik V. Reiss, Anne Ziplys, Heiko Weichert, Saskia Hiltemann, José M. Ugalde, Andreas J. Meyer, John C. D'Auria, Stefan A. Rensing, Jos H. M. Schippers   +12 more
wiley   +1 more source

Flavin binding to the high affinity riboflavin transporter RibU

, 2007
The first biochemical and spectroscopic characterization of a purified membrane transporter for riboflavin (vitamin B2) is presented. The riboflavin transporter RibU from the bacterium Lactococcus lactis was overexpressed, solubilized, and purified.
Dirk Jan Slotboom, Ria H. Duurkens, Menno B. Tol, Tol, Menno B., Permentier, Hjalmar P., Geertsma, Eric R., Slotboom, Dirk Jan, Permentier, Hjalmar P.; id_orcid, Hjalmar P. Permentier, Eric R. Geertsma, Duurkens, Hinderika   +10 more
core   +1 more source

Erythrocyte Pathophysiology of Riboflavin deficiency in rats [PDF]

Pathophysiology of erythrocytes from riboflavin-deficient rats has been investigated. Riboflav in-deficiency was produced by feeding a riboflavin-deficient diet ad-libitum to weanling male Wistar specified pathogen-free, albino rats (40-SOg) housed ...
Hassan, FM
core   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment [PDF]

, 2010
We report on three patients (two siblings and one unrelated) presenting in infancy with progressive muscle weakness and paralysis of the diaphragm. Metabolic studies revealed a profile of plasma acylcarnitines and urine organic acids suggestive of a mild
Duran, M., Wanders, R.J., Frits A. Wijburg, Ronald J. Wanders, Annet M. Bosch, Marinus Duran, Bosch, A.M., Lodewijk IJlst, Ijlst, L., Knoester, H., Visser, G., Waterham, H.R., Gepke Visser, Stroomer, A.E.M., van der Pol, W.L., Hennie Knoester, Alida E. M. Stroomer, Wijburg, F.A., Abeling, N.G.G.M., Nico G. G. M. Abeling, W. Ludo van der Pol, Hans R. Waterham   +21 more
core   +1 more source