Results 131 to 140 of about 433,059 (284)
Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism
The FEBS Journal, EarlyView.IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang +7 more
wiley +1 more source
Affinity chromatography of porcine pancreatic ribonuclease reinvestigation of the N-terminal amino acid sequence [PDF]
, 1973 Beintema, J.J. +4 more
core +2 more sources
Neocortical neurogenesis: a proneural gene perspective
The FEBS Journal, EarlyView.The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan +3 more
wiley +1 more source
The Landscape of SPP1+ Macrophages Across Tissues and Diseases: A Comprehensive Review
Immunology, EarlyView.SPP1+ macrophages represent a conserved, disease‐associated population present across cancerous and non‐cancerous conditions, involved in immunosuppression, fibrosis, lipid metabolism, phagocytosis, and other cellular processes. This review highlights their shared molecular programmes across tissues, their interactions with stromal and immune cells ...
Alessandro Palma
wiley +1 more source
Mechanism of Action of Bovine Pancreatic Ribonuclease [PDF]
Biochemical Journal, 1966 A. P. Mathias, Brian R. Rabin, A. Deavin
openaire +5 more sources
Journal of Fish Diseases, Volume 48, Issue 4, April 2025.ABSTRACT Atlantic cod farming experiences renewed growth in Norway, and increased awareness is essential to address emerging diseases in this species. There are few reports on gill diseases in cod, and to date, no viral gill infections of cod have been documented. In this study, we collected samples from three sequential time points in summer 2023 from
Mona C. Gjessing +4 more
wiley +1 more source
Journal of Fish Diseases, EarlyView.ABSTRACT Mx genes display strong and quick induction in response to viral infections, which varies according to the viral virulence; furthermore, mx transcription is blocked by several viruses as part of their immune evasion strategies. Therefore, the level and time course of mx induction reflect virus–host interplay. This idea prompted the development
Daniel Álvarez‐Torres +4 more
wiley +1 more source
Alternative Splicing Regulation in Metabolic Disorders
Obesity Reviews, EarlyView.ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley +1 more source
The primary structure of giraffe pancreatic ribonuclease [PDF]
FEBS Letters, 1974 Gerda Groen +3 more
openaire +3 more sources
Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins
The Journal of Physiology, EarlyView.Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape +4 more
wiley +1 more source