Results 31 to 40 of about 433,059 (284)
Molecular evolution of pancreatic-type ribonucleases. [PDF]
Molecular Biology and Evolution, 1986 Amino acid sequences of 39 mammalian ribonucleases have been used to construct trees by the maximum parsimony procedure. These trees are in fairly good agreement with the biological classification of the species involved. In the branching order of the six investigated eutherian mammalian orders, the edentates diverge first, followed, probably, by the ...
BEINTEMA J. J. +2 more
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F1000Research, 2018 Deoxyoligonucleotide binding to bovine pancreatic ribonuclease A (RNase A) was investigated using electrospray ionization ion-trap mass spectrometry (ESI-IT-MS). Deoxyoligonucleotides included CCCCC (dC5) and CCACC (dC2AC2).
Daniel D. Clark
doaj +1 more source
Frontiers in Genetics, 2021 Background: Recently, RNA-binding proteins (RBPs) were reported to interact with target mRNA to regulate gene posttranscriptional expression, and RBP-mediated RNA modification can regulate the expression and function of proto-oncogenes and tumor ...
Xin Wen +10 more
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Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism.
Biochemistry, 2011 Fifty years ago, the group of Tony Mathias and Bob Rabin at University College London deduced the first mechanism for catalysis by an enzyme, ribonuclease [Findlay, D., Herries, D. G., Mathias, A. P., Rabin, B. R., and Ross, C. A.
C. M. Cuchillo +2 more
semanticscholar +1 more source
F1000Research, 2018 Deoxyoligonucleotide binding to bovine pancreatic ribonuclease A (RNase A) was investigated using electrospray ionization ion-trap mass spectrometry (ESI-IT-MS). Deoxyoligonucleotides included CCCCC (dC5) and CCACC (dC2AC2).
Daniel D. Clark
doaj +1 more source
Functional plasticity of antibacterial EndoU toxins. [PDF]
, 2018 Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein.
Eschenfeldt, William H +11 more
core +1 more source
Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases
Molecules, 2018 Ribonucleases are proteins whose use is promising in anticancer therapy. We have previously constructed different human pancreatic ribonuclease variants that are selectively cytotoxic for tumor cells by introducing a nuclear localization signal into ...
David Roura Padrosa +5 more
doaj +1 more source
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]
, 2013 Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba +10 more
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Ligand-Induced Variations in Structural and Dynamical Properties Within an Enzyme Superfamily
Frontiers in Molecular Biosciences, 2018 Enzyme catalysis is a complex process involving several steps along the reaction coordinates, including substrate recognition and binding, chemical transformation, and product release.
Chitra Narayanan +7 more
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Affinity Labeling of Pancreatic Ribonuclease
Journal of Biological Chemistry, 1971 Abstract Pyridoxal phosphate can be firmly bound by reduction with sodium borohydride to many enzymes in which it occurs. Such treatment has been used to label specifically parts of peptide chains in the vicinity of the bound coenzyme. Pyridoxal phosphate may form specific complexes with many proteins for which it has no known coenzyme function. Bovine
Gary E. Means, Robert E. Feeney
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