Results 11 to 20 of about 156,401 (384)
Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni
eLife, 2019 CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma mansoni as proof of principle.
Wannaporn Ittiprasert +20 more
doaj +2 more sources
The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily
Vaccines, 2018 The Ribonuclease A Superfamily is composed of cationic peptides that are secreted by immune cells and epithelial tissues. Although their physiological roles are unclear, several members of the vertebrate Ribonuclease A Superfamily demonstrate ...
Laura Schwartz +3 more
doaj +2 more sources
THE OXIDATION OF RIBONUCLEASE WITH PERFORMIC ACID
Journal of Biological Chemistry, 1956 C.H.W. Hirs
openalex +2 more sources
ACS Central Science, 2020 COVID-19 is a global pandemic, thus requiring multiple strategies to develop modalities against it. Herein, we designed multiple bioactive small molecules that target a functional structure within the SARS-CoV-2’s RNA genome, the causative agent of COVID-
Hafeez S Haniff +10 more
semanticscholar +1 more source
Structural investigations of proteins encoded by SARS‐CoV‐2
FEBS Open Bio, 2022 It is hard to overestimate the influence of the COVID‐19 pandemic on scientific research in the last two and a half years. Within a few weeks after the first cases of the disease were reported, the causative agent, now known as SARS‐CoV‐2, was identified,
Alexander Wlodawer
doaj +1 more source
Biomolecules, 2022 The translation factor IF5A is a highly conserved protein playing a well-recognized and well-characterized role in protein synthesis; nevertheless, some of its features as well as its abundance in the cell suggest that it may perform additional functions
Alice Romagnoli +8 more
doaj +1 more source
Nature Communications, 2020 Bacterial and archaeal CRISPR-Cas systems provide RNA-guided immunity against genetic invaders such as bacteriophages and plasmids. Upon target RNA recognition, type III CRISPR-Cas systems produce cyclic-oligoadenylate second messengers that activate ...
C. Garcia-Doval +8 more
semanticscholar +1 more source
RNase Y Autoregulates Its Synthesis in Bacillus subtilis
Microorganisms, 2023 The instability of messenger RNA is crucial to the control of gene expression. In Bacillus subtilis, RNase Y is the major decay-initiating endoribonuclease.
Anna Korobeinikova +3 more
doaj +1 more source
Specific antibodies against binase: Preparation and application
Учёные записки Казанского университета: Серия Естественные науки, 2021 Secreted ribonuclease of Bacillus pumilus (binase) is a promising antitumor agent with established selective cytotoxicity against various types of cancer cells expressing specific oncogenes.
V.I. Vershinina +4 more
doaj +1 more source
eLife, 2020 Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to ...
Januka S Athukoralage +5 more
doaj +1 more source