Results 21 to 30 of about 145,501 (289)

Ribonucleases as potential therapeutic agents [PDF]

مجله بیوتکنولوژی کشاورزی, 2021
Objective Due to high cytotoxicity effect, ribonucleases (RNases) are known as pharmacological agents with therapeutic potential. The high potential of these enzymes in the destruction of RNA strand and their other substrates and subsequently, cell ...
Masoume Vakili-Azghandi, Mohammadreza Nasiri, Shahrokh Ghovvati, Ali Javadmanesh   +3 more
doaj   +1 more source

Identification of Crucial Amino Acid Residues for Antimicrobial Activity of Angiogenin 4 and Its Modulation of Gut Microbiota in Mice

Frontiers in Microbiology, 2022
Angiogenin 4 bearing ribonuclease activity is an endogenous antimicrobial protein expressed in small and large intestine. However, the crucial amino acid residues responsible for the antibacterial activity of Ang4 and its impact on gut microbiota remain ...
Mst. Farzana Sultana, Mst. Farzana Sultana, Maki Suzuki, Fumiya Yamasaki, Wataru Kubota, Kohta Takahashi, Hirohito Abo, Hiroto Kawashima   +7 more
doaj   +1 more source

RNase Y Autoregulates Its Synthesis in Bacillus subtilis

Microorganisms, 2023
The instability of messenger RNA is crucial to the control of gene expression. In Bacillus subtilis, RNase Y is the major decay-initiating endoribonuclease.
Anna Korobeinikova, Soumaya Laalami, Clément Berthy, Harald Putzer   +3 more
doaj   +1 more source

Structural investigations of proteins encoded by SARS‐CoV‐2

FEBS Open Bio, 2022
It is hard to overestimate the influence of the COVID‐19 pandemic on scientific research in the last two and a half years. Within a few weeks after the first cases of the disease were reported, the causative agent, now known as SARS‐CoV‐2, was identified,
Alexander Wlodawer
doaj   +1 more source

Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2

Protein & Cell, 2017
Mammalian mitochondrial genome encodes a small set of tRNAs, rRNAs, and mRNAs. The RNA synthesis process has been well characterized. How the RNAs are degraded, however, is poorly understood. It was long assumed that the degradation happens in the matrix
Peipei Liu, Jinliang Huang, Qian Zheng, Leiming Xie, Xinping Lu, Jie Jin, Geng Wang   +6 more
doaj   +1 more source

The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

eLife, 2020
Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to ...
Januka S Athukoralage, Shirley Graham, Christophe Rouillon, Sabine Grüschow, Clarissa M Czekster, Malcolm F White   +5 more
doaj   +1 more source

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]

, 2017
Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J., Cain, Katharine, Chalmers, Fiona, Sweeney, Bernadette, van Lith, Marcel   +4 more
core   +2 more sources

Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]

, 2020
Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
core   +1 more source

Effect of osmotic stress on in vitro translational capacity of polysomes and on the composition of polysome-associated proteins in germinating seeds of pea (Pisum sativum L.)

Acta Societatis Botanicorum Poloniae, 2012
Plant growth throughout the world is often limited by unfavourable environmental conditions. This paper reports results of a study on long- and short-term osmotic stress (−0.5 MPa) followed by a recovery on in vitro translational capacity of polysomes ...
Wioletta Brosowska-Arendt, Stanisław Weidner   +1 more
doaj   +1 more source

Identification of the catalytic motif of the microbial ribosome inactivating cytotoxin colicin E3 [PDF]

, 2004
Colicin E3 is a cytotoxic ribonuclease that specifically cleaves 16S rRNA at the ribosomal A-site to abolish protein synthesis in sensitive Escherichia coli cells.
Bohm, Boon, Bowman, Carr, Cuchillo, Garinot-Schneider, Irie, Kerr, Kleanthous, Kleanthous, Makarov, Mosbahi, Ogawa, Ohno, Ohno, Ohno-Iwashita, Parret, Pommer, Rojas, Scholz, Schultz, Sidikaro, Smarda, Soelaiman, Steege, Tomita, Walker, Walker, Walker, Walker, Wallis   +30 more
core   +2 more sources