Identification of the Acinetobacter baumannii Ribonuclease P Catalytic Subunit: Cleavage of a Target mRNA in the Presence of an External Guide Sequence [PDF]
Frontiers in Microbiology, 2018 The bacterial ribonuclease P or RNase P holoenzyme is usually composed of a catalytic RNA subunit, M1, and a cofactor protein, C5. This enzyme was first identified for its role in maturation of tRNAs by endonucleolytic cleavage of the pre-tRNA. The RNase
Carol Davies-Sala +6 more
doaj +2 more sources
Eukaryotic Ribonuclease P: A Plurality of Ribonucleoprotein Enzymes [PDF]
Annual Review of Biochemistry, 2002 ▪ Abstract Ribonuclease P (RNase P) is an essential endonuclease that acts early in the tRNA biogenesis pathway. This enzyme catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5′ end of tRNAs. RNase P activities have been identified in Bacteria, Archaea, and Eucarya, as well as organelles.
Shaohua Xiao +3 more
openalex +4 more sources
Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences [PDF]
Molecular Therapy: Nucleic Acids, 2017 External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA.
Wei Li +9 more
doaj +4 more sources
Subsites for substrate recognition by bacterial ribonuclease P [PDF]
Nucleic Acids Symposium Series, 2008 We have prepared series of shape variant RNAs of a tRNA precursor and analyzed the substrate shape recognition by bacterial ribonuclease P ribozyme and holoenzyme. The results showed the evidence for the presence of subsites for the recognition of the trna shape.
Atsuko Fujimoto +4 more
openalex +4 more sources
Bacterial RNA-free RNase P: Structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P [PDF]
J Biol Chem, 2023 Catherine A. Wilhelm +10 more
openalex +2 more sources
Modulation of ribonuclease P activity by calcipotriol [PDF]
European Journal of Biochemistry, 2000 The effects of cholesterol, 7‐dehydrocholesterol, vitamin D3 and several synthetic vitamin D3 analogs on ribonuclease P (RNase P) were investigated using a cell‐free system from the slime mold Dictyostelium discoideum. RNase P is an ubiquitous and essential enzyme that endonucleolytically cleaves all tRNA precursors to produce the mature 5′ end.
Evangelia Papadimou +4 more
openalex +4 more sources
Ribonuclease P: function and variation.
Journal of Biological Chemistry, 1990 Norman R. Pace, Danielle Smith
openalex +4 more sources
Distributive enzyme binding controlled by local RNA context results in 3′ to 5′ directional processing of dicistronic tRNA precursors byEscherichia coliribonuclease P [PDF]
Nucleic Acids Res, 2018 Jing Zhao, Michael E. Harris
openalex +2 more sources
Structure of a bacterial ribonuclease P holoenzyme in complex with tRNA [PDF]
Nature, 2010 Nicholas J. Reiter +5 more
openalex +3 more sources
Production of ovine Pancreatic Ribonuclease and investigation of enzyme characteristics [PDF]
پژوهشهای علوم دامی ایران, 2021 Introduction Obviously, the recent decades strategy in cancer therapy, anticancer drug discovery and drug improvement is to characterize, distinguish and validate the most promising cancer-related molecular targets to which new drugs can be designed. The
mahsa Zabetian +3 more
doaj +1 more source