Identification of the Acinetobacter baumannii Ribonuclease P Catalytic Subunit: Cleavage of a Target mRNA in the Presence of an External Guide Sequence [PDF]
Frontiers in Microbiology, 2018 The bacterial ribonuclease P or RNase P holoenzyme is usually composed of a catalytic RNA subunit, M1, and a cofactor protein, C5. This enzyme was first identified for its role in maturation of tRNAs by endonucleolytic cleavage of the pre-tRNA. The RNase
Carol Davies-Sala +6 more
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Eukaryotic Ribonuclease P: A Plurality of Ribonucleoprotein Enzymes [PDF]
Annual Review of Biochemistry, 2002 ▪ Abstract Ribonuclease P (RNase P) is an essential endonuclease that acts early in the tRNA biogenesis pathway. This enzyme catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5′ end of tRNAs. RNase P activities have been identified in Bacteria, Archaea, and Eucarya, as well as organelles.
Shaohua Xiao +3 more
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Subsites for substrate recognition by bacterial ribonuclease P [PDF]
Nucleic Acids Symposium Series, 2008 We have prepared series of shape variant RNAs of a tRNA precursor and analyzed the substrate shape recognition by bacterial ribonuclease P ribozyme and holoenzyme. The results showed the evidence for the presence of subsites for the recognition of the trna shape.
Atsuko Fujimoto +4 more
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Bacterial RNA-free RNase P: Structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P. [PDF]
J Biol Chem, 2023 Wilhelm CA +10 more
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Modulation of ribonuclease P activity by calcipotriol [PDF]
European Journal of Biochemistry, 2000 The effects of cholesterol, 7‐dehydrocholesterol, vitamin D3 and several synthetic vitamin D3 analogs on ribonuclease P (RNase P) were investigated using a cell‐free system from the slime mold Dictyostelium discoideum. RNase P is an ubiquitous and essential enzyme that endonucleolytically cleaves all tRNA precursors to produce the mature 5′ end.
Evangelia Papadimou +4 more
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Ribonuclease P: function and variation.
Journal of Biological Chemistry, 1990 Norman R. Pace, Danielle Smith
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Distributive enzyme binding controlled by local RNA context results in 3' to 5' directional processing of dicistronic tRNA precursors by Escherichia coli ribonuclease P. [PDF]
Nucleic Acids Res, 2019 Zhao J, Harris ME.
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Structure of a bacterial ribonuclease P holoenzyme in complex with tRNA. [PDF]
Nature, 2010 Reiter NJ +5 more
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Production of ovine Pancreatic Ribonuclease and investigation of enzyme characteristics [PDF]
پژوهشهای علوم دامی ایران, 2021 Introduction Obviously, the recent decades strategy in cancer therapy, anticancer drug discovery and drug improvement is to characterize, distinguish and validate the most promising cancer-related molecular targets to which new drugs can be designed. The
mahsa Zabetian +3 more
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Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P
RNA Biology, 2023 RNA-based enzyme RNase P is a ribonucleoprotein complex responsible primarily for 5’-maturation of tRNAs. S. cerevisiae RNase P comprises a catalytic RNA component and nine proteins. The assembly and maturation of S.
Anna Perederina +2 more
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