Results 21 to 30 of about 331,224 (206)

RPP40 is a prognostic biomarker and correlated with tumor microenvironment in uterine corpus endometrial carcinoma

Frontiers in Oncology, 2022
Ribonuclease P/MRP Subunit P40 (RPP40), a component of ribonuclease P and multimeric ribonuclease P complex, was reported as one of the promoting factors for the chemoresistance of acute myeloid leukemia and a recurrence predictor of early-stage triple ...
Jianming Tang, Xiaoli Tian, Jie Min, Ming Hu, Li Hong   +4 more
doaj   +1 more source

Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes

Molecules, 2022
Naturally occurring ribozymes with a modular architecture are promising platforms for construction of RNA nanostructures because modular redesign enables their oligomerization.
Mst. Ayesha Siddika, Takahiro Yamada, Risako Aoyama, Kumi Hidaka, Hiroshi Sugiyama, Masayuki Endo, Shigeyoshi Matsumura, Yoshiya Ikawa   +7 more
doaj   +1 more source

The Ribonuclease P database [PDF]

Nucleic Acids Research, 1994
The Ribonuclease P Sequence database is a compilation of RNase P sequences, sequence alignments, secondary structures, three-dimensional models, and accessory information. In its initial form, the database contains information on RNase P RNA in bacteria and archaea, and RNase P protein in bacteria.
J W, Brown, E S, Haas, D G, Gilbert, N R, Pace   +3 more
openaire   +2 more sources

P finder: genomic and metagenomic annotation of RNase P RNA gene (rnpB)

BMC Genomics, 2020
Background The rnpB gene encodes for an essential catalytic RNA (RNase P). Like other essential RNAs, RNase P’s sequence is highly variable. However, unlike other essential RNAs (i.e.
J. Christopher Ellis
doaj   +1 more source

Dissecting Monomer-Dimer Equilibrium of an RNase P Protein Provides Insight Into the Synergistic Flexibility of 5’ Leader Pre-tRNA Recognition

Frontiers in Molecular Biosciences, 2021
Ribonuclease P (RNase P) is a universal RNA-protein endonuclease that catalyzes 5’ precursor-tRNA (ptRNA) processing. The RNase P RNA plays the catalytic role in ptRNA processing; however, the RNase P protein is required for catalysis in vivo and ...
Danyun Zeng, Ainur Abzhanova, Benjamin P. Brown, Benjamin P. Brown, Nicholas J. Reiter   +4 more
doaj   +1 more source

The Ribonuclease P Database [PDF]

Nucleic Acids Research, 1996
Ribonuclease P is responsible for the 5'-maturation of tRNA precursors. Ribonuclease P is a ribonucleoprotein, and in bacteria (and some Archaea) the RNA subunit alone is catalytically active in vitro, i.e. it is a ribozyme. The Ribonuclease P Database is a compilation of ribonuclease P sequences, sequence alignments, secondary structures, three ...
openaire   +9 more sources

One-step refolding and purification of disulfide-containing proteins with a C-terminal MESNA thioester

BMC Biotechnology, 2008
Background Expression systems based on self-cleavable intein domains allow the generation of recombinant proteins with a C-terminal thioester. This uniquely reactive C-terminus can be used in native chemical ligation reactions to introduce synthetic ...
Merkx Maarten, Meijer EW, van Baal Ingrid, Bastings Maartje MC   +3 more
doaj   +1 more source

Rational Design of an Orthogonal Pair of Bimolecular RNase P Ribozymes through Heterologous Assembly of Their Modular Domains

Biology, 2019
The modular structural domains of multidomain RNA enzymes can often be dissected into separate domain RNAs and their noncovalent assembly can often reconstitute active enzymes.
Yuri Nozawa, Megumi Hagihara, Md Sohanur Rahman, Shigeyoshi Matsumura, Yoshiya Ikawa   +4 more
doaj   +1 more source

Inhibition of Ribonuclease P Activity by Retinoids [PDF]

Journal of Biological Chemistry, 1998
The effect of two naturally occurring (retinol and all-trans retinoic acid) and two synthetic (isotretinoin and acitretin) analogs of vitamin A (retinoids) on tRNA biogenesis was investigated employing the RNase P of Dictyostelium discoideum as an in vitro experimental system.
S. Georgiou, Denis Drainas, D. Tsambaos, Evangelia Papadimou   +3 more
openaire   +3 more sources

Suppressing Kaposi’s Sarcoma-Associated Herpesvirus Lytic Gene Expression and Replication by RNase P Ribozyme

Molecules, 2023
Kaposi’s sarcoma, an AIDS-defining illness, is caused by Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic virus. In this study, we engineered ribozymes derived from ribonuclease P (RNase P) catalytic RNA with targeting against the mRNA ...
Yujun Liu, Yuan-Chuan Chen, Bin Yan, Fenyong Liu   +3 more
doaj   +1 more source