Results 1 to 10 of about 12,181 (245)

Colletotrichum fructicola co-opts cytotoxic ribonucleases that antagonize host competitive microorganisms to promote infection [PDF]

mBio
Phytopathogens secrete numerous molecules into the environment to establish a microbial niche and facilitate host infection. The phytopathogenic fungus Colletotrichum fructicola, which causes pear anthracnose, can colonize different plant tissues like ...
Chunhao Wang, Mengqing Han, Yanyan Min, Jiayi Hu, Yuemin Pan, Lili Huang, Jiajun Nie   +6 more
doaj   +2 more sources

Defining the networks that connect RNase III and RNase J-mediated regulation of primary and specialized metabolism in Streptomyces venezuelae [PDF]

Journal of Bacteriology
RNA metabolism involves coordinating RNA synthesis with RNA processing and degradation. Ribonucleases play fundamental roles within the cell, contributing to the cleavage, modification, and degradation of RNA molecules, with these actions ensuring ...
Meghan A. D. Pepler, Emma L. Mulholland, Freddie R. Montague, Marie A. Elliot   +3 more
doaj   +2 more sources

Specific Targeting of Recombinant Human Pancreatic Ribonuclease 1 using Gonadotropin-Releasing Hormone Targeting Peptide toward Gonadotropin-Releasing Hormone Receptor-Positive Cancer Cells [PDF]

Iranian Journal of Medical Sciences, 2021
Background: Targeted drug delivery is a novel method to specifically deliver anticancer therapeutics to tumor sites. Gonadotropin-releasing hormone (GnRH) is a decapeptide, and its target binding property has attracted attention as a means of targeted ...
Amir Maleksabet, Hossein Zarei Jaliani, Amir Asgari, Amin Ramezani, Nasrollah Erfani   +4 more
doaj   +1 more source

S-Like Ribonuclease T2 Genes Are Induced during Mobilisation of Nutrients in Cotyledons from Common Bean

Agronomy, 2021
Germination and seedling development are crucial phases in a plant’s life cycle with economical and agronomical implications. The RNA quality in seeds is linked to seed viability, being an important agronomic trait since this leads to a loss in ...
Mercedes Diaz-Baena, Elena Delgado-García, Manuel Pineda, Gregorio Galvez-Valdivieso, Pedro Piedras   +4 more
doaj   +1 more source

Developing New Tools to Fight Human Pathogens: A Journey through the Advances in RNA Technologies

Microorganisms, 2022
A long scientific journey has led to prominent technological advances in the RNA field, and several new types of molecules have been discovered, from non-coding RNAs (ncRNAs) to riboswitches, small interfering RNAs (siRNAs) and CRISPR systems.
Vanessa G. Costa, Susana M. Costa, Margarida Saramago, Marta V. Cunha, Cecília M. Arraiano, Sandra C. Viegas, Rute G. Matos   +6 more
doaj   +1 more source

Ribonucleases as potential therapeutic agents [PDF]

مجله بیوتکنولوژی کشاورزی, 2021
Objective Due to high cytotoxicity effect, ribonucleases (RNases) are known as pharmacological agents with therapeutic potential. The high potential of these enzymes in the destruction of RNA strand and their other substrates and subsequently, cell ...
Masoume Vakili-Azghandi, Mohammadreza Nasiri, Shahrokh Ghovvati, Ali Javadmanesh   +3 more
doaj   +1 more source

The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs

Microorganisms, 2022
The pandemic caused by SARS-CoV-2 is not over yet, despite all the efforts from the scientific community. Vaccination is a crucial weapon to fight this virus; however, we still urge the development of antivirals to reduce the severity and progression of ...
Margarida Saramago, Vanessa G. Costa, Caio S. Souza, Cátia Bárria, Susana Domingues, Sandra C. Viegas, Diana Lousa, Cláudio M. Soares, Cecília M. Arraiano, Rute G. Matos   +9 more
doaj   +1 more source

Ribonuclease-Responsive DNA Nanoswitches

Cell Reports Physical Science, 2020
Summary: DNA has been used in the construction of dynamic DNA devices that can reconfigure in the presence of external stimuli. These nanodevices have found uses in fields ranging from biomedical to materials science applications.
Arun Richard Chandrasekaran, Ruju Trivedi, Ken Halvorsen   +2 more
doaj   +1 more source

Horse Pancreatic Ribonuclease [PDF]

European Journal of Biochemistry, 1974
Horse ribonuclease was purified after acid extraction of pancreas by ammonium sulfate fractionation and chromatography on CM‐cellulose. It is a glycoprotein with an average molecular weight of about 18000. The pure enzyme was chromatographically and electrophoretically heterogeneous due to the heterogeneity of the carbohydrate moiety.The amino‐acid ...
SCHEFFER, AJ, BEINTEMA, JJ
openaire   +3 more sources

Preliminary studies on ribonucleases from Poa pratensis seeds

Acta Societatis Botanicorum Poloniae, 2015
Ribonuclease was extracted from Poa pratensis seeds with 0.1 M acetate buffer, pH 5.1, and then precipitated with alcohol. The enzyme was separated into 5 fractions (I-V) after chromatography on DEAE-cellulose at pH 5.1.
Irena Lorenc-Kubis, Bronisława Morawiecka   +1 more
doaj   +1 more source