Results 91 to 100 of about 139,231 (236)
Autoantibodies to ribonucleoprotein particles containing U2 small nuclear RNA. [PDF]
The EMBO Journal, 1985 Autoantibodies exclusively precipitating U1 and U2 small nuclear ribonucleoprotein (snRNP) particles [anti-(U1,U2)RNP] were detected in sera from four patients with autoimmune disorders. When tested by immunoblotting, these sera recognized up to four different protein antigens in purified mixtures of U1-U6 RNP particles.
W. J. Van Venrooij +4 more
openaire +3 more sources
The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly
Cell Reports, 2017 Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival of motor neuron (SMN) protein. SMN is part of a multiprotein complex that facilitates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs).
Paul G. Donlin-Asp +7 more
doaj +1 more source
Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain. [PDF]
PLoS ONE, 2010 Spinal muscular atrophy (SMA) is a leading genetic cause of childhood mortality, caused by reduced levels of survival motor neuron (SMN) protein. SMN functions as part of a large complex in the biogenesis of small nuclear ribonucleoproteins (snRNPs).
Jennifer L Fuentes +2 more
doaj +1 more source
The Nefarious Nexus of Noncoding RNAs in Cancer [PDF]
, 2018 The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts.
Anastasiadou, Eleni +3 more
core +1 more source
Advanced Science, EarlyView.Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai +14 more
wiley +1 more source
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
Single molecule analysis reveals reversible and irreversible steps during spliceosome activation
eLife, 2016 The spliceosome is a complex machine composed of small nuclear ribonucleoproteins (snRNPs) and accessory proteins that excises introns from pre-mRNAs.
Aaron A Hoskins +4 more
doaj +1 more source
BMS1 is mutated in aplasia cutis congenita. [PDF]
PLoS Genetics, 2013 Aplasia cutis congenita (ACC) manifests with localized skin defects at birth of unknown cause, mostly affecting the scalp vertex. Here, genome-wide linkage analysis and exome sequencing was used to identify the causative mutation in autosomal dominant ...
Alexander G Marneros
doaj +1 more source
The ever-evolving concept of the gene: The use of RNA/Protein experimental techniques to understand genome functions [PDF]
, 2018 The completion of the human genome sequence together with advances in sequencing technologies have shifted the paradigm of the genome, as composed of discrete and hereditable coding entities, and have shown the abundance of functional noncoding DNA. This
Ballarino, Monica, Cipriano, Andrea
core +2 more sources
Cell Reports, 2012 The spinal muscular atrophy (SMA) protein, survival motor neuron (SMN), functions in the biogenesis of small nuclear ribonucleoproteins (snRNPs). SMN has also been implicated in tissue-specific functions; however, it remains unclear which of these is ...
Kavita Praveen +2 more
doaj +1 more source