Results 131 to 140 of about 139,231 (236)
Journal of Biological Chemistry, 2000 We describe a novel approach to identify RNA-protein cross-linking sites within native small nuclear ribonucleoprotein (snRNP) particles from HeLa cells. It combines immunoprecipitation of the UV-irradiated particles under semi-denaturing conditions with
H. Urlaub +4 more
semanticscholar +1 more source
Brazilian Journal of Medical and Biological Research, 2004 Cajal bodies (CB) are ubiquitous nuclear structures involved in the biogenesis of small nuclear ribonucleoproteins and show narrow association with the nucleolus. To identify possible relationships between CB and the nucleolus, the localization of coilin,
N.P. Silva +3 more
doaj +1 more source
The intriguing case of motor neuron disease: ALS and SMA come closer [PDF]
, 2013 MNDs (motor neuron diseases) form a heterogeneous group of pathologies characterized by the progressive degeneration of motor neurons. More and more genetic factors associated with MND encode proteins that have a function in RNA metabolism, suggesting ...
Achsel, T +3 more
core +1 more source
Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges
Advanced Genetics, EarlyView.This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley +1 more source
Synthesis and assembly of human small nuclear ribonucleoproteins generated by cell-free translation.
Proceedings of the National Academy of Sciences of the United States of America, 1983 Cell-free translation of human poly(A)+ RNA was carried out to generate and analyze the protein constituents of small nuclear ribonucleoprotein (snRNP) particles.
D. Fisher +4 more
semanticscholar +1 more source
Phosphorylation regulates coilin activity and RNA association
Biology Open, 2013 Summary The Cajal body (CB) is a domain of concentrated components found within the nucleus of cells in an array of species that is functionally important for the biogenesis of telomerase and small nuclear ribonucleoproteins.
Hanna J. Broome +3 more
doaj +1 more source
Clinical impact of splicing in neurodevelopmental disorders. [PDF]
, 2020 Clinical exome sequencing is frequently used to identify gene-disrupting variants in individuals with neurodevelopmental disorders. While splice-disrupting variants are known to contribute to these disorders, clinical interpretation of cryptic splice ...
Farh, Kyle Kai-How +2 more
core +1 more source
Systematic discovery of structural elements governing stability of mammalian messenger RNAs. [PDF]
, 2012 Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour.
Cristea, Ileana M +7 more
core +2 more sources
Helvetica Chimica Acta, Accepted Article.Pairwise distance root mean square deviation defines a hyperspace where conformers with similar shape reside close to each other. The radius of gyration of protein ensembles in this abstract conformer space (ACS) converges at ensemble sizes between 50 and 500, depending on the extent of disorder.
Gunnar Jeschke
wiley +1 more source
Involvement of U1 Small Nuclear Ribonucleoproteins (snRNP) in 5′ Splice Site-U1 snRNP Interaction*
Journal of Biological Chemistry, 1996 U1 small nuclear ribonucleoprotein (snRNP) is an important ribonucleoprotein involved early in the spliceosome formation to commit pre-mRNAs to the splicing pathway.
F. Rossi +5 more
semanticscholar +1 more source