Disease Models & Mechanisms, 2017 Unique deficits in the function of adult sensory neurons as part of their early neurodegeneration might account for progressive polyneuropathy during chronic diabetes mellitus.
Masaki Kobayashi +6 more
doaj +1 more source
Anomalous HIV-1 RNA, How Cap-Methylation Segregates Viral Transcripts by Form and Function
Viruses, 2022 The acquisition of m7G-cap-binding proteins is now recognized as a major variable driving the form and function of host RNAs. This manuscript compares the 5′-cap-RNA binding proteins that engage HIV-1 precursor RNAs, host mRNAs, small nuclear (sn)- and ...
Kathleen Boris-Lawrie +5 more
doaj +1 more source
An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly [PDF]
, 2017 ACKNOWLEDGEMENTS Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We would also like to thank Prof.
Albrecht +54 more
core +1 more source
Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair
Advanced Science, EarlyView.CircGLIS3(2), a circRNA transiently upregulated in dermal fibroblasts during acute wound healing, is induced by IL‐1α and TGF‐β. Its RNA activates fibroblasts into matrix‐secreting cells, while its encoded protein enhances proliferation. The RNA stabilizes PCOLCE, and the protein interacts with BTF3, collectively accelerating wound repair. Abstract The
Guanglin Niu +20 more
wiley +1 more source
The C-group Heterogeneous Nuclear Ribonucleoprotein Proteins Bind to the 5′ Stem-Loop of the U2 Small Nuclear Ribonucleoprotein Particle [PDF]
Journal of Biological Chemistry, 1996 The C-group heterogeneous nuclear ribonucleoprotein (hnRNP) proteins bind to nascent pre-messenger RNA. In vitro studies have indicated that the C hnRNP proteins bind particularly strongly to the intron polypyrimidine tract of pre-mRNA and may be important for pre-mRNA splicing.
Thoru Pederson, Jamal Temsamani
openaire +3 more sources
Assembly and budding of influenza virus. [PDF]
, 2004 Influenza viruses are causative agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family.
Barman, Subrata +2 more
core
The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis [PDF]
, 2014 Cajal bodies (CBs) are nuclear organelles involved in the maturation of spliceosomal small nuclear ribonucleoproteins (snRNPs). They concentrate coilin, snRNPs and the survival motor neuron protein (SMN).
Bühler +34 more
core +2 more sources
Advanced Science, EarlyView.In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang +10 more
wiley +1 more source
A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility
Advanced Science, EarlyView.This study identifies SR30, a splicing factor, as a negative regulator of tomato immunity. During Phytophthora infestans infection, the elevated SR30 forms nuclear condensates to suppress the alternative splicing (AS) of defense‐related genes in a phase separation manner.
Dong Yan +11 more
wiley +1 more source
Viral small nuclear ribonucleoproteins bind a protein implicated in messenger RNA destabilization.
Proceedings of the National Academy of Sciences of the United States of America, 1992 Herpesvirus saimiri (HVS) is one of several primate viruses that carry genes for small RNAs. The five H. saimiri-encoded U RNAs (HSURs) are the most abundant viral transcripts expressed in transformed marmoset T lymphocytes.
V. Myer, Susanna I. Lee, Joan A. Steitz
semanticscholar +1 more source