Results 201 to 210 of about 38,830 (350)

The G protein‐coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells

open access: yesThe FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara   +9 more
wiley   +1 more source

Accelerating Cleavage Activity of CRISPR-Cas13 System on a Microfluidic Chip for Rapid Detection of RNA. [PDF]

open access: yesAnal Chem
Kim J   +9 more
europepmc   +1 more source

The quest for the best target genes for RNAi‐mediated pest control

open access: yesInsect Molecular Biology, EarlyView.
A major challenge for RNAi mediated pest control is the identification of the most effective RNAi target genes from the pool of ~37% of all genes that are essential. Effective RNAi target genes are predominantly highly conserved genes serving basic cellular functions such as protein degradation.
Doga Cedden, Gregor Bucher
wiley   +1 more source

Shorter Telomeres and Faster Telomere Attrition in Individuals With Five Syndromic Forms of Intellectual Disability: A Systematic Review and Meta‐Analysis

open access: yesJournal of Intellectual Disability Research, EarlyView.
ABSTRACT Background People with intellectual disability suffer complex challenges due to adaptive functioning limitations, high rates of chronic diseases and shortened lifespans compared with the general population. Telomere shortening is a hallmark of ageing, and short telomeres are linked to neurological disorders.
Sarah M. Hanley   +3 more
wiley   +1 more source

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