Shock-Induced Degradation of Guanosine and Uridine Promoted by Nickel and Carbonate: Potential Applications [PDF]
Molecules, 2023 Experimental studies of the degradation of two ribonucleosides (guanosine and uridine) were carried out by making use of mechanochemistry. Mechanochemical experiments reveal the decomposition of guanosine and uridine, promoted by nickel(II) and carbonate
Gustavo P. Maia +3 more
doaj +2 more sources
Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer [PDF]
Cellular and Molecular Life SciencesPost-transcriptional modifications on mRNA are crucial for mRNA fate and function. The current lack of a comprehensive method for high-coverage and sensitive quantitative analysis of mRNA modifications significantly limits the discovery of new mRNA ...
Ying Feng +11 more
doaj +2 more sources
Response of Escherichia coli chemotaxis pathway to pyrimidine deoxyribonucleosides [PDF]
Microbiology SpectrumNucleosides are essential components of all living cells. Bacteria use salvage pathways to import nucleosides from their environment and to utilize them for nucleic acid biosynthesis, but also as alternative sources of carbon, nitrogen and energy. Motile
Malay Shah, Wenhao Xu, Victor Sourjik
doaj +2 more sources
Novel Antimicrobial Activities of Albofungin, Albonoursin, and Ribonucleosides Produced by Streptomyces sp. Caat 5-35 Against Phytopathogens and Their Potential as a Biocontrol Agent [PDF]
MoleculesThe genus Streptomyces is the largest group within the phylum Actinobacteria, recognized for producing antibiotics and enzymes, with wide applications in medicine and biological control for crop protection against phytopathogens.
Carmen Julia Pedroza-Padilla +4 more
doaj +2 more sources
Naturally occurring modified ribonucleosides [PDF]
WIREs RNA, 2020 AbstractThe chemical identity of RNA molecules beyond the four standard ribonucleosides has fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in 1951. Since then, the ever‐increasing number and complexity of modified ribonucleosides have been found in viruses and throughout all three domains of life.
Phillip J. McCown +7 more
openaire +2 more sources
Frontiers in Molecular Biosciences, 2021 RNA methylation plays a significant regulatory role in various of physiological activities and it has gradually become a hotspot of epigenetics in the past decade.
Zhihao Fang +8 more
doaj +1 more source
Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine [PDF]
Biochemical Pharmacology, 1995 6-Methylmercaptopurine ribonucleoside-5'-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor of purine de novo synthesis, inducing depletion of intracellular purine nucleotides and subsequent cell death in several tumor cell lines.
Stet, E.H. +6 more
openaire +5 more sources
Photoactivatable ribonucleosides mark base-specific RNA-binding sites
Nature Communications, 2021 RNA-protein interactions play critical roles in post-transcriptional gene regulation. Here the authors demonstrate pRBS-ID, an updated MS/MS-based method that combines the benefits of photoactivatable ribonucleosides and the chemical cleavage of RNA.
Jong Woo Bae +3 more
doaj +1 more source
Ribonucleoside Hydrolases–Structure, Functions, Physiological Role and Practical Uses
Biomolecules, 2023 Ribonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria, archaea, protozoa, metazoans, yeasts, fungi and plants.
Leonid A. Shaposhnikov +3 more
doaj +1 more source
Metabolites, 2022 Accumulating evidence supports the important role of RNA modifications in liver disease pathogenesis. However, RNA modifications in alcohol-associated liver disease (ALD) have not yet been reported.
Liqing He +7 more
doaj +1 more source