Results 11 to 20 of about 6,161 (198)
Naturally occurring modified ribonucleosides [PDF]
WIREs RNA, 2020 AbstractThe chemical identity of RNA molecules beyond the four standard ribonucleosides has fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in 1951. Since then, the ever‐increasing number and complexity of modified ribonucleosides have been found in viruses and throughout all three domains of life.
Phillip J. McCown +7 more
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Frontiers in Molecular Biosciences, 2021 RNA methylation plays a significant regulatory role in various of physiological activities and it has gradually become a hotspot of epigenetics in the past decade.
Zhihao Fang +8 more
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The taste of ribonucleosides: Novel macronutrients essential for larval growth are sensed by Drosophila gustatory receptor proteins. [PDF]
PLoS Biology, 2018 Animals employ various types of taste receptors to identify and discriminate between different nutritious food chemicals. These macronutrients are thought to fall into 3 major groups: carbohydrates/sugars, proteins/amino acids, and fats.
Dushyant Mishra +4 more
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Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine [PDF]
Biochemical Pharmacology, 1995 6-Methylmercaptopurine ribonucleoside-5'-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor of purine de novo synthesis, inducing depletion of intracellular purine nucleotides and subsequent cell death in several tumor cell lines.
Stet, E.H. +6 more
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Photoactivatable ribonucleosides mark base-specific RNA-binding sites
Nature Communications, 2021 RNA-protein interactions play critical roles in post-transcriptional gene regulation. Here the authors demonstrate pRBS-ID, an updated MS/MS-based method that combines the benefits of photoactivatable ribonucleosides and the chemical cleavage of RNA.
Jong Woo Bae +3 more
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Metabolites, 2022 Accumulating evidence supports the important role of RNA modifications in liver disease pathogenesis. However, RNA modifications in alcohol-associated liver disease (ALD) have not yet been reported.
Liqing He +7 more
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BBA Advances, 2021 Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers.Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modifications to RNA ...
Norman H.L. Chiu +3 more
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Learning from the Invaders: What Viruses Teach Us about RNA-Based Regulation in Microbes
Microorganisms, 2022 Viruses feature an evolutionary shaped minimal genome that is obligately dependent on the cellular transcription and translation machinery for propagation.
L. Peter Sarin
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Molecules, 2022 An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established ...
Virginia Martín-Nieves +3 more
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PLoS Pathogens, 2012 Ribonucleoside analogues have potential utility as anti-viral, -parasitic, -bacterial and -cancer agents. However, their clinical applications have been limited by off target effects.
Jamie J Arnold +18 more
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