Results 11 to 20 of about 4,163 (154)

A theoretical perspective of the physical properties of different RNA modifications with respect to RNA duplexes

BBA Advances, 2021
Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers.Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modifications to RNA ...
Norman H.L. Chiu, Jennifer H. Simpson, Hongzhou Wang, Bakhos A. Tannous   +3 more
doaj   +1 more source

Learning from the Invaders: What Viruses Teach Us about RNA-Based Regulation in Microbes

Microorganisms, 2022
Viruses feature an evolutionary shaped minimal genome that is obligately dependent on the cellular transcription and translation machinery for propagation.
L. Peter Sarin
doaj   +1 more source

Sustainable Protocol for the Synthesis of 2′,3′-Dideoxynucleoside and 2′,3′-Didehydro-2′,3′-dideoxynucleoside Derivatives

Molecules, 2022
An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established ...
Virginia Martín-Nieves, Yogesh S. Sanghvi, Susana Fernández, Miguel Ferrero   +3 more
doaj   +1 more source

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.

PLoS Pathogens, 2012
Ribonucleoside analogues have potential utility as anti-viral, -parasitic, -bacterial and -cancer agents. However, their clinical applications have been limited by off target effects.
Jamie J Arnold, Suresh D Sharma, Joy Y Feng, Adrian S Ray, Eric D Smidansky, Maria L Kireeva, Aesop Cho, Jason Perry, Jennifer E Vela, Yeojin Park, Yili Xu, Yang Tian, Darius Babusis, Ona Barauskus, Blake R Peterson, Averell Gnatt, Mikhail Kashlev, Weidong Zhong, Craig E Cameron   +18 more
doaj   +1 more source

Structural and Molecular Basis for Mitochondrial DNA Replication and Transcription in Health and Antiviral Drug Toxicity

Molecules, 2023
Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation.
Joon Park, Noe Baruch-Torres, Y. Whitney Yin   +2 more
doaj   +1 more source

Synthesis of Disaccharide Nucleosides Utilizing the Temporary Protection of the 2′,3′-cis-Diol of Ribonucleosides by a Boronic Ester

Molecules, 2017
Disaccharide nucleosides are an important class of natural compounds that have a variety of biological activities. In this study, we report on the synthesis of disaccharide nucleosides utilizing the temporary protection of the 2′,3′-cis-diol of ...
Hidehisa Someya, Taiki Itoh, Shin Aoki
doaj   +1 more source

Practical Silyl Protection of Ribonucleosides [PDF]

Organic Letters, 2013
Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows for the selective silylation of the 3'-hydroxyl, which could be used in the synthesis of unnatural ...
Thomas P, Blaisdell, Sunggi, Lee, Pinar, Kasaplar, Xixi, Sun, Kian L, Tan   +4 more
openaire   +2 more sources

The taste of ribonucleosides: Novel macronutrients essential for larval growth are sensed by Drosophila gustatory receptor proteins.

PLoS Biology, 2018
Animals employ various types of taste receptors to identify and discriminate between different nutritious food chemicals. These macronutrients are thought to fall into 3 major groups: carbohydrates/sugars, proteins/amino acids, and fats.
Dushyant Mishra, Natasha Thorne, Chika Miyamoto, Christopher Jagge, Hubert Amrein   +4 more
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Nucleobase Protection of Deoxyribo‐ and Ribonucleosides [PDF]

Current Protocols in Nucleic Acid Chemistry, 2017
AbstractOligonucleotides carrying a variety of chemical modifications including conjugates are finding increasing applications in therapeutics, diagnostics, functional genomics, proteomics, and as research tools in chemical and molecular biology. The successful synthesis of oligonucleotides primarily depends on the use of appropriately protected ...
Geeta, Meher, Nabin K, Meher, Radhakrishnan P, Iyer   +2 more
openaire   +5 more sources

Characterizing Benzo[a]pyrene Adducts in Transfer RNAs Using Liquid Chromatography Coupled with Tandem Mass Spectrometry (LC-MS/MS)

Biomedicines, 2023
The activated forms of the environmental pollutant benzo[a]pyrene (B[a]P), such as benzo[a]pyrene diol epoxide (BPDE), are known to cause damage to genomic DNA and proteins. However, the impact of BPDE on ribonucleic acid (RNA) remains unclear.
Cassandra Herbert, Corinna L. Ohrnberger, Ella Quinlisk, Balasubrahmanyam Addepalli, Patrick A. Limbach   +4 more
doaj   +1 more source