Results 11 to 20 of about 9,338 (256)
Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes. [PDF]
ChembiochemIn the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Décout JL, Maurel MC.
europepmc +2 more sources
Deoxyribo‐ and Ribonucleoside H‐Phosphonates [PDF]
Current Protocols in Nucleic Acid Chemistry, 2001 AbstractMost methods for preparing H‐phosphonate monoesters suffer from variable yields and are often incompatible with common protecting groups used in oligonucleotide synthesis. This unit describes four procedures that consistently give high yields of the desired products.
Jacek Stawiński, Roger Strömberg
openalex +5 more sources
An Intestinal Phosphorylase for Uric Acid Ribonucleoside
Journal of Biological Chemistry, 1963 Leonard Laster, Alberta Blair
openalex +4 more sources
Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine [PDF]
Biochemical Pharmacology, 1995 6-Methylmercaptopurine ribonucleoside-5'-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor of purine de novo synthesis, inducing depletion of intracellular purine nucleotides and subsequent cell death in several tumor cell lines.
Stet, E.H. +6 more
openaire +6 more sources
Nucleobase Protection of Deoxyribo‐ and Ribonucleosides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2000 AbstractProtecting groups for the imide/lactam function of thymine/uracil and guanine, respectively, prevent irreversible nucleobase modifications that may occur in the presence of alkylating or condensing reagents that are commonly used in nucleoside protection and oligonucleotide synthesis.
Geeta Meher +2 more
openaire +6 more sources
Photoactivatable ribonucleosides mark base-specific RNA-binding sites
Nature Communications, 2021 RNA-protein interactions play critical roles in post-transcriptional gene regulation. Here the authors demonstrate pRBS-ID, an updated MS/MS-based method that combines the benefits of photoactivatable ribonucleosides and the chemical cleavage of RNA.
Jong Woo Bae +3 more
doaj +1 more source
Molecular Ecology, EarlyView., 2023 Abstract Malaria is a mosquito‐borne disease caused by protozoans of the genus Plasmodium that affects both humans and wildlife. The fitness consequences of infections by avian malaria are well known in birds, however, little information exists on its impact on mosquitoes.
Marta Garrigós +4 more
wiley +1 more source
Metabolites, 2022 Accumulating evidence supports the important role of RNA modifications in liver disease pathogenesis. However, RNA modifications in alcohol-associated liver disease (ALD) have not yet been reported.
Liqing He +7 more
doaj +1 more source
Learning from the Invaders: What Viruses Teach Us about RNA-Based Regulation in Microbes
Microorganisms, 2022 Viruses feature an evolutionary shaped minimal genome that is obligately dependent on the cellular transcription and translation machinery for propagation.
L. Peter Sarin
doaj +1 more source
Molecules, 2022 An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established ...
Virginia Martín-Nieves +3 more
doaj +1 more source