Results 21 to 30 of about 9,338 (256)
Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues [PDF]
RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents ...
Barr, Eric W.+11 more
core +4 more sources
Ribonucleosides as minor milk constituents [PDF]
Ribonucleosides are minor milk constituents and show a typical pattern which is assumed to be species-specific. As well as the unmodified components adenosine, cytidine, guanosine, inosine, and uridine, modified compounds such as Nl-methyladenosine and N6-carbamoylthreonyladenosine--products of the transfer RNA catabolism--have been identified and ...
Ott, F.-G., Raezke, K.-P., Schlimme, E.
core +4 more sources
Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation.
Joon Park+2 more
doaj +1 more source
Phosphorylation of purine and pyrimidine nucleosides by isolated rat liver mitochondria [PDF]
Formation of 5'-AMP, 5'-GMP, 5'-CMP and 5'UMP was confirmed in isolated rat liver mitochondria incubated with alpha-ketoglutarate, inorganic phosphate, purine nucleoside and pyrimidine nucleoside. Increased incorporation of 32Pi into ATP, GTP and UTP was
Inaba, Kozo, Oda, Takuzo
core +1 more source
His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]
The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M.+3 more
core +1 more source
Disaccharide nucleosides are an important class of natural compounds that have a variety of biological activities. In this study, we report on the synthesis of disaccharide nucleosides utilizing the temporary protection of the 2′,3′-cis-diol of ...
Hidehisa Someya, Taiki Itoh, Shin Aoki
doaj +1 more source
A System of RNA Modifications and Biased Codon Use Controls Cellular Stress Response at the Level of Translation [PDF]
Cells respond to environmental stressors and xenobiotic exposures using regulatory networks to control gene expression, and there is an emerging appreciation for the role of numerous postsynthetic chemical modifications of DNA, RNA, and proteins in ...
Begley, Thomas J., Dedon, Peter C
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Permeability of Coxiella burnetii to ribonucleosides [PDF]
Knowledge about transport in Coxiella burnetii, an obligate phagolysosomal parasite, is incomplete. The authors investigated the capability of isolated, intact, host-free Coxiella to transport ribonucleosides while incubated at a pH value typical of lysosomes.
Jeffrey D. Miller, Herbert A. Thompson
openaire +3 more sources
A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress [PDF]
Decades of study have revealed more than 100 ribonucleoside structures incorporated as post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional dynamics of this conserved system are unclear. To this end, we developed a highly
Clement T. Y. Chan+6 more
core +4 more sources
ChemInform Abstract: SYNTHESIS OF TRICYCLIC RIBONUCLEOSIDES
AbstractDas Kaliumsalz des Mercaptoinosins (I) wird mit Dibromalkanen (II) bzw. (V) in Gegenwart von Alkali zu den tricyclischen Verbindungen (III) bzw. (VI) umgesetz Im Falle des Dibrompentans (VII) wird nur ein Bis‐(thioinosyl)‐pentan (VIII) isoli Beim Erhitzen mit alkoholischer Salzsäure wird aus dem Ribonucleosid (III) der Ribofuranosylrest unter ...
Mikio Honjo+2 more
openaire +4 more sources