Results 21 to 30 of about 6,161 (198)
Molecules, 2023 Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation.
Joon Park +2 more
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Molecules, 2017 Disaccharide nucleosides are an important class of natural compounds that have a variety of biological activities. In this study, we report on the synthesis of disaccharide nucleosides utilizing the temporary protection of the 2′,3′-cis-diol of ...
Hidehisa Someya, Taiki Itoh, Shin Aoki
doaj +1 more source
Nucleobase Protection of Deoxyribo‐ and Ribonucleosides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2017 AbstractOligonucleotides carrying a variety of chemical modifications including conjugates are finding increasing applications in therapeutics, diagnostics, functional genomics, proteomics, and as research tools in chemical and molecular biology. The successful synthesis of oligonucleotides primarily depends on the use of appropriately protected ...
Geeta, Meher +2 more
openaire +5 more sources
Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions
Angewandte Chemie, EarlyView.This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan +3 more
wiley +2 more sources
Molecules, 2011 There are more than 100 different ribonucleoside structures incorporated as post-transcriptional modifications, mainly in tRNA and rRNA of both prokaryotes and eukaryotes, and emerging evidence suggests that these modifications function as a system in ...
Peter C. Dedon +8 more
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Biomimetic Ketone Reduction by Disulfide Radical Anion
Molecules, 2021 The conversion of ribonucleosides to 2′-deoxyribonucleosides is catalyzed by ribonucleoside reductase enzymes in nature. One of the key steps in this complex radical mechanism is the reduction of the 3′-ketodeoxynucleotide by a pair of cysteine residues,
Sebastian Barata-Vallejo +5 more
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Ribonucleosides, Aminoacyl- and Peptidyl-RNA: Synthesis, Thermodynamics, and Structure
CHIMIA, 1999 Ribonucleosides, RNA and peptides are prepared to study non-covalent interactions of RNA, aminoacyl- and peptidyl-RNA. Techniques used include chemical synthesis in solution and on solid supports, UV- and NM-detected thermal denaturation, X-ray ...
Ewa Biala +3 more
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Tikrit Journal of Pure Science, 2023 One of the hydrolytic enzymes that catalyzes the hydrolysis of 5' -nucleotides into ribonucleosides and phosphate is the 5'nucleotidase, which is found in several organs.
Sameer M. Al-Gorany +1 more
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Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues
Molecules, 2014 In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O ...
Abdelaaziz Ouahrouch +4 more
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MoleculesThe emergence of RNA viruses driven by global population growth and international trade highlights the urgent need for effective antiviral agents that can inhibit viral replication.
Evan Saillard +4 more
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