Results 31 to 40 of about 4,163 (154)

DNA Flap‐Mediated Control of Transcription for Programmable RNA Synthesis

Angewandte Chemie International Edition, EarlyView.
Pyrimidine‐rich ssDNA flaps on the T7 promoter inhibit T7 RNA polymerase (T7RP) transcription. Leveraging this pyrimidine bias, we developed DNAzyme‐ and MNAzyme‐mediated flap promoter induced transcription control (D‐FIT and M‐FIT) systems. These platforms enable regulated transcription and sequence‐specific detection, highlighting the programmable ...
Eun Sung Lee, Jisu Woo, Seokjoon Kim, Seok Hyeon Kim, Gun Haeng Lee, Ki Soo Park   +5 more
wiley   +1 more source

Permeability of Coxiella burnetii to ribonucleosides [PDF]

Microbiology, 2002
Knowledge about transport in Coxiella burnetii, an obligate phagolysosomal parasite, is incomplete. The authors investigated the capability of isolated, intact, host-free Coxiella to transport ribonucleosides while incubated at a pH value typical of lysosomes.
Jeffrey D, Miller, Herbert A, Thompson
openaire   +2 more sources

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Synthesis of [5‘-¹³C]Ribonucleosides and 2‘-Deoxy[5‘-¹³C]ribonucleosides [PDF]

The Journal of Organic Chemistry, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Etsuko, Kawashima, Kaoru, Umabe, Takeshi, Sekine   +2 more
openaire   +2 more sources

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Preparation of a disulfide-linked precipitative soluble support for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3´-(2-chlorophenylphosphate) building blocks

Beilstein Journal of Organic Chemistry, 2015
The preparation of a disulfide-tethered precipitative soluble support and its use for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3´-(2-chlorophenylphosphate) building blocks is described. To obtain the building blocks, N-acyl protected
Amit M. Jabgunde, Alejandro Gimenez Molina, Pasi Virta, Harri Lönnberg   +3 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker

BMC Veterinary Research, 2021
Background Thymidine kinase 1 (TK1) catalyzes the initial phosphorylation of thymidine in the salvage pathway synthesis of dTTP, an essential building block of DNA. TK1 is a cytosolic enzyme with its highest level during the S-phase of the cell cycle. In
Liya Wang, Hanan Sharif, Sara Saellström, Henrik Rönnberg, Staffan Eriksson   +4 more
doaj   +1 more source

Tumor‐Infiltrating Nociceptor Neurons in Ovarian Cancer Treatment Resistance

Advanced Biology, Volume 10, Issue 3, March 2026.
This study shows that high‐grade serous ovarian carcinomas (HGSOC) are significantly more innervated than the other histological subtypes. HGSOC small extracellular vesicles (sEVs) promote neurite outgrowth in vitro. Analysis of pre‐ and post‐treatment HGSOC samples shows that innervation increases post‐chemotherapy.
Allison Jorgensen, Daniel W. Vermeer, Euihye Jung, Caitlin S. Williamson, Dalia K. Omran, Lauren E. Schwartz, Ju‐Yoon Yoon, Jeffrey Barr, Ashley L. Tetlow, Camille V. Trinidad, Ronny Drapkin, Andrew K. Godwin, Paola D. Vermeer   +12 more
wiley   +1 more source

Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

Viruses, 2018
Viral RNA-dependent RNA polymerases (RdRps) play a central role not only in viral replication, but also in the genetic evolution of viral RNAs. After binding to an RNA template and selecting 5′-triphosphate ribonucleosides, viral RdRps synthesize an RNA ...
Barbara Selisko, Nicolas Papageorgiou, François Ferron, Bruno Canard   +3 more
doaj   +1 more source