Results 31 to 40 of about 6,161 (198)

Second Generation of Antisense Oligonucleotides: From Nuclease Resistance to Biological Efficacy in Animals

CHIMIA, 1996
From efforts to improve the biophysical properties of antisense oligonucleotides by incorporating backbone- or sugar-modified nucleoside analogs, 2'-O-methoxyethyl ribonucleosides 8b were identified as building blocks for a second generation of ...
Karl-Heinz Altmann, Henri Sasmor, Uwe Pieles, Judy Phillipsd, Paul Nicklind, Fram;ois Natt, Marcel Miiller, Brett P.B Monia, Pierre Martina, Dieter A Hiisken, Robert Hanera, Thomas Geiger, Susan M. Freier, Doriano Fabbro, Nicholas M. Dean, Heinz E Moser   +15 more
doaj   +2 more sources

A functional genomics approach to establish the complement of carbohydrate transporters in Streptococcus pneumoniae. [PDF]

PLoS ONE, 2012
The aerotolerant anaerobe Streptococcus pneumoniae is part of the normal nasopharyngeal microbiota of humans and one of the most important invasive pathogens.
Alessandro Bidossi, Laura Mulas, Francesca Decorosi, Leonarda Colomba, Susanna Ricci, Susanna Ricci, Gianni Pozzi, Josef Deutscher, Carlo Viti, Marco Rinaldo Oggioni   +9 more
doaj   +1 more source

Permeability of Coxiella burnetii to ribonucleosides [PDF]

Microbiology, 2002
Knowledge about transport in Coxiella burnetii, an obligate phagolysosomal parasite, is incomplete. The authors investigated the capability of isolated, intact, host-free Coxiella to transport ribonucleosides while incubated at a pH value typical of lysosomes.
Jeffrey D, Miller, Herbert A, Thompson
openaire   +2 more sources

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Synthesis of [5‘-¹³C]Ribonucleosides and 2‘-Deoxy[5‘-¹³C]ribonucleosides [PDF]

The Journal of Organic Chemistry, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Etsuko, Kawashima, Kaoru, Umabe, Takeshi, Sekine   +2 more
openaire   +2 more sources

Preparation of a disulfide-linked precipitative soluble support for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3´-(2-chlorophenylphosphate) building blocks

Beilstein Journal of Organic Chemistry, 2015
The preparation of a disulfide-tethered precipitative soluble support and its use for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3´-(2-chlorophenylphosphate) building blocks is described. To obtain the building blocks, N-acyl protected
Amit M. Jabgunde, Alejandro Gimenez Molina, Pasi Virta, Harri Lönnberg   +3 more
doaj   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker

BMC Veterinary Research, 2021
Background Thymidine kinase 1 (TK1) catalyzes the initial phosphorylation of thymidine in the salvage pathway synthesis of dTTP, an essential building block of DNA. TK1 is a cytosolic enzyme with its highest level during the S-phase of the cell cycle. In
Liya Wang, Hanan Sharif, Sara Saellström, Henrik Rönnberg, Staffan Eriksson   +4 more
doaj   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma

BMC Molecular and Cell Biology, 2021
Background Thymidine kinase 1 (TK1) plays a key role in the synthesis of deoxythymidine triphosphate (dTTP) and is thus important for DNA replication and cell proliferation.
Liya Wang, Lucia Unger, Hanan Sharif, Staffan Eriksson, Vinzenz Gerber, Henrik Rönnberg   +5 more
doaj   +1 more source