Results 51 to 60 of about 14,695 (294)

Position-dependent effects of regioisomeric methylated adenine and guanine ribonucleosides on translation

open access: yesNucleic Acids Research, 2017
Reversible methylation of the N6 or N1 position of adenine in RNA has recently been shown to play significant roles in regulating the functions of RNA. RNA can also be alkylated upon exposure to endogenous and exogenous alkylating agents.
Changjun You, X. Dai, Yinsheng Wang
semanticscholar   +1 more source

Modular, Step-Efficient Palladium-Catalyzed Cross-Coupling Strategy To Access C6-Heteroaryl 2-Aminopurine Ribonucleosides.

open access: yesOrganic Letters, 2017
Two Pd-catalyzed methods to access 6-heteroaryl 2-aminopurine ribonucleosides from 6-chloroguanosine are described. First, Pd-132-catalyzed Suzuki-Miyaura cross-coupling using a series of boron substrates and 6-chloroguanosine forms 6-heteroaryl-2 ...
Helena S Buchanan   +8 more
semanticscholar   +1 more source

Induction of chromosome damage by ultraviolet light and caffeine: Correlation of cytogenetic evaluation and flow karyotype [PDF]

open access: yes, 1982
Asynchrononously growing cells of a M3-1 Chinese hamster line were ultraviolet (UV) irradiated ( = 254 nm) with UV fluences up to 7.5 J/m2. After irradiation, cells were incubated with or without 2 mM caffeine for 20 hr, then mitotic cells were selected ...
Carrano   +20 more
core   +1 more source

Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]

open access: yes, 2012
Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair   +2 more
core   +2 more sources

A functional genomics approach to establish the complement of carbohydrate transporters in Streptococcus pneumoniae. [PDF]

open access: yesPLoS ONE, 2012
The aerotolerant anaerobe Streptococcus pneumoniae is part of the normal nasopharyngeal microbiota of humans and one of the most important invasive pathogens.
Alessandro Bidossi   +9 more
doaj   +1 more source

Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3‐Triazolylbenzyl‐aminophosphonates

open access: yesArchiv der Pharmazie, 2015
A novel series of ribonucleosides of 1,2,3‐triazolylbenzyl‐aminophosphonates was synthesized through the Kabachnik–Fields reaction using I2 as catalyst followed by copper‐catalyzed cycloaddition of the azide–alkyne reaction (CuAAC). All structures of the
Abdelaaziz Ouahrouch   +6 more
semanticscholar   +1 more source

Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis [PDF]

open access: yes, 2005
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since ...
Blagova, E V   +6 more
core   +3 more sources

Second Generation of Antisense Oligonucleotides: From Nuclease Resistance to Biological Efficacy in Animals

open access: yesCHIMIA, 1996
From efforts to improve the biophysical properties of antisense oligonucleotides by incorporating backbone- or sugar-modified nucleoside analogs, 2'-O-methoxyethyl ribonucleosides 8b were identified as building blocks for a second generation of ...
Karl-Heinz Altmann   +15 more
doaj   +2 more sources

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

open access: yesAdvanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li   +11 more
wiley   +1 more source

rNMPID: a database for riboNucleoside Mono-Phosphates In DNA

open access: yesBioinformatics Advances, 2023
AbstractMotivationRibonucleoside monophosphates (rNMPs) are the most abundant non-standard nucleotides embedded in genomic DNA. If the presence of rNMP in DNA cannot be controlled, it can lead to genome instability. The actual positive functions of rNMPs in DNA remain mainly unknown.
Jingcheng Yang   +6 more
openaire   +2 more sources

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