Results 51 to 60 of about 4,163 (154)

Transient Cyclic Structured Oligonucleotide Designs for Therapeutic Applications

Current Protocols, Volume 6, Issue 2, February 2026.
Abstract Oligonucleotide‐based therapeutics are now widely used in clinical settings. From the late 1980s to the mid‐1990s, efforts to improve therapeutic efficacy focused on imparting drug‐like properties to oligonucleotides, emphasizing nuclease stability and target sequence affinity.
Sudhir Agrawal
wiley   +1 more source

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidative, inflammatory and metabolic function in recipient cells.
Sungji Cho, Hye Kyoung Sung, Khang Nguyen, Yubin Lei, Sivaporn Wannaiampikul, Brian Lee, Eddie Tam, Yihan Luo, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kacey J. Prentice, Scott A Summers, Dylan Burger, Gary Sweeney   +13 more
wiley   +1 more source

A General Method for Selective Tritylation of Primary Hydroxyl Groups in Carbohydrates and Related Compounds [PDF]

Journal of Sciences, Islamic Republic of Iran, 1989
A general and rapid procedure is developed for the selective tritylation of the 'primary OH-function of the four common ribonucleosides, ascorbic acid, and polyhydric compounds.
doaj  

Sex‐Specific Renal Proteomic Responses to Mycotoxins and Their Mitigation by Bioactive Food Ingredients

Molecular Nutrition &Food Research, Volume 70, Issue 4, 26 February 2026.
In vivo exposure to AFB1 and OTA markedly disrupts proteomic patterns in rats, with males showing heightened sensitivity. Fermented whey and pumpkin alleviated toxin‐induced molecular damage by decreasing differentially expressed proteins, demonstrating their potential to mitigate molecular disturbances and supporting their role as functional dietary ...
Fojan Agahi, Alessandra Cimbalo, Lara Manyes   +2 more
wiley   +1 more source

Diversity, Function and Activity of DNA Viruses in the Qiangyong Proglacial Lake Sediment, the Tibetan Plateau

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
This study identified DNA viruses from Qiangyong proglacial lake sediments on the Tibetan Plateau, revealing a highly diverse and previously uncharacterized viral community. These viruses influence microbial community structure and function by infecting key nutrient‐transforming taxa and encoding auxiliary metabolic genes that modulate host metabolism.
Yang Zhao, Meiling Feng, Hongfei Chi, Keshao Liu, Rong Wen, Weizhen Zhang, Pengfei Liu   +6 more
wiley   +1 more source

Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance

Frontiers in Molecular Biosciences, 2017
Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome.
Matthew J. Young
doaj   +1 more source

Flavones and Aminoflavones Increase the Cytotoxicity of NK Cells in Human Non‐Small Cell Lung Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT Natural flavonoids (flavones) and synthetic aminoflavones are known for their anti‐cancer properties; however, their immunomodulation ability has been largely unexplored. This study determined that synthetic flavones and aminoflavones modulate the cytotoxicity of natural killer (NK) cells against lung cancer cells.
Ping‐Chih Hsu, Chih‐Cheng Chien, Yang‐Je Cheng, Chuan‐Hsin Chang, Tzenge‐Lien Shih   +4 more
wiley   +1 more source

ClAPRT3‐Mediated Adenine Salvage Pathway Enhances Purine Metabolites to Sustain Seed Vigour During Selfing in Cunninghamia lanceolata

Plant Biotechnology Journal, Volume 24, Issue 2, Page 547-566, February 2026.
ABSTRACT Selfing often causes inbreeding depression, especially during seed and seedling stages. However, some selfed progeny show low inbreeding depression with enhanced vigour, differing from inbred counterparts. This study investigates the molecular mechanisms maintaining seed vigour during selfing in Cunninghamia lanceolata.
Houyin Deng, Ye Zhao, Jie Liu, Kunjin Han, Juan Han, Meng Ke, Rong Huang, Ruping Wei, Yousry A. El‐Kassaby, Runhui Wang, Shu Yan, Yuhan Sun, Yun Li, Huiquan Zheng   +13 more
wiley   +1 more source

A Convenient Synthesis of Ribonucleoside 2', 3', -Cyclic Phosphates from Ribonucleosides and Ribonucleotides

Chemical and Pharmaceutical Bulletin, 1970
Adenosine 5'-phosphate was converted to the 2', 3'-cyclic phosphate by the treatment with dimethylformamide at reflux temperature. The reaction was shown to be proceeded by the initial release of the phosphoryl group as an"activated phosphoric acid"and rephosphorylated to furnish the 2', 3'-cyclic phosphate. In fact a ribonucleoside and phosphoric acid,
TOHRU UEDA, IKUKO KAWAI
openaire   +2 more sources

Protecting Groups for the Synthesis of Ribonucleic Acids

CHIMIA, 2001
Methods for the regioselective introduction of alkoxymethyl-groups into the 2?-O-position of 5?-O-dimethoxytritylated, nucleobase-protected ribonucleosides and for the N-alkyloxycarbonylation of adenine and guanine nucleosides were developed ...
Stefan Pitsch
doaj