Results 51 to 60 of about 6,161 (198)

Biocatalytic Construction of a Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Nucleoside Probe: Synthesis and Evaluation of 5‐Methyl‐5,6‐Dihydrothymidine

Advanced Synthesis &Catalysis, Volume 368, Issue 1, January 2026.
Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady, Zinia Mohanta, Michael T. McMahon, Milana Bazayeva, Zhen Li, Kenneth M. Merz Jr., Assaf A. Gilad   +8 more
wiley   +1 more source

Proximity‐Induced Ligation of Noncomplementary Oligonucleotides Triggered by Charge‐Transfer Interactions

ChemistryEurope, Volume 4, Issue 1, January 2026.
Charge‐transfer assisted ligation (CTAL) enables ultrafast CuAAC and SPAAC conjugation of a tetra‐DiAlkoxyNaphthalene (DAN4)‐azide and a noncomplementary tetraNaphthaleneDiImide (NDI4)‐alkyne oligonucleotide under dilute conditions, and the reaction can be carried out tracelessly by subsequently removing the tags.
Laura Nicollet, Kévan Pérez de Carvasal, Nessrine Graidia, François Morvan, Michael Smietana   +4 more
wiley   +1 more source

Biochemical and Comparative Proteomic Analyses Delineate the Anti‐Ovarian Carcinogenic Roles of Modified Calycosin

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Fuhong Yang, Xin Li, Hanchi Gao, Pei Yao, Xian Qin, Xiao Lin, Keng Po Lai, Jing Tian, Jian Chen   +8 more
wiley   +1 more source

Rice Bran Supplements the Nutritional Density of Ready‐to‐Use Therapeutic Foods: A Targeted Nutrient and Non‐Targeted Metabolomic Analysis

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Incorporating rice bran in ready‐to‐use therapeutic foods (RUTFs) was used for treatment of childhood malnutrition. RUTF nutrient analysis showed increased dietary fiber and vitamins E and B1. Non‐targeted metabolomics revealed significant changes in lipids, amino acids, carbohydrates, vitamins, and phytochemicals corresponding to rice bran.
Annika M. Weber, Emma S. Bovaird, Sahar B. Toulabi, Silvia Barbazza, Moretta Damayanti Fauzi, Fildzah K. Putri, Khaerul Fadly, Kharisma Tamimi, Diva M. Calvimontes, Rimbawan Rimbawan, Zuraidah Nasution, Puspo Edi Giriwono, Frank T. Wieringa, Elizabeth P. Ryan   +13 more
wiley   +1 more source

A General Method for Selective Tritylation of Primary Hydroxyl Groups in Carbohydrates and Related Compounds [PDF]

Journal of Sciences, Islamic Republic of Iran, 1989
A general and rapid procedure is developed for the selective tritylation of the 'primary OH-function of the four common ribonucleosides, ascorbic acid, and polyhydric compounds.
doaj  

Yerba Mate (Ilex paraguariensis A. St.‐Hil.) Reduces Oxidative Stress and Bone Resorption in Apical Periodontitis

International Endodontic Journal, Volume 59, Issue 1, Page 91-104, January 2026.
ABSTRACT Aim Apical periodontitis (AP) is a highly prevalent chronic inflammatory disease that can exert systemic effects by releasing biochemical mediators that initiate and regulate the immune response. Yerba Mate (Ilex paraguariensis, YM), a popular plant broadly consumed in South America, is rich in biologically active compounds known for their ...
Carolina Sayuri Wajima, Carolina de Barros Morais Cardoso, Caroline Anselmi, Renan Dal‐Fabbro, Murilo Catelani Ferraz, Cristiane Cantiga da Silva, Paulo César Ciarlini, Edilson Ervolino, Marco Cícero Bottino, Luciano Tavares Angelo Cintra   +9 more
wiley   +1 more source

Ras Homolog Enriched in Brain Protein Reverses Amyloid Beta‐Induced Escape of Inflammatory Cytokine mRNAs From Immunoisolated RNA Processing Bodies of Glioblastoma Cells

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
A detergent‐based method, combined with immunoprecipitation using an anti‐P‐body component‐specific antibody, was used to isolate RNAs associated with RNA processing bodies (PBs) from both neuronal and glial cells. In neurons, β‐amyloid oligomers helped to trap specific mRNAs related to neuronal differentiation into PBs.
Sritama Ray, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance

Frontiers in Molecular Biosciences, 2017
Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome.
Matthew J. Young
doaj   +1 more source

From MS1 to Structure: A Van Krevelen–DBE–Aromaticity‐Based Framework for Annotating Specialized Metabolites via High‐Resolution Mass Spectrometry

Rapid Communications in Mass Spectrometry, Volume 39, Issue 24, 30 December 2025.
ABSTRACT Rationale Classifying specialized metabolites in untargeted metabolomics remains a major challenge, particularly when relying solely on high‐resolution mass spectrometry (HRMS) data at the MS1 level. Traditional approaches using Van Krevelen diagrams often lack sufficient resolution to distinguish structurally similar metabolite classes ...
Nerilson M. Lima, Luana A. Pereira, Lucas S. Tironi, Matheus P. G. do Carmo, Milbya L. Costa, Renato A. Oliveira, Salva Asghar, Vinicius Fortes da Silva   +7 more
wiley   +1 more source

Protecting Groups for the Synthesis of Ribonucleic Acids

CHIMIA, 2001
Methods for the regioselective introduction of alkoxymethyl-groups into the 2?-O-position of 5?-O-dimethoxytritylated, nucleobase-protected ribonucleosides and for the N-alkyloxycarbonylation of adenine and guanine nucleosides were developed ...
Stefan Pitsch
doaj